Abstract
Objective
Chronic congestive liver dysfunction in advanced valvular disease remains an important co-morbidity in open heart surgery. The objective of this study was to explore the prognostic value in patients with severe valvular disease associated with congestive liver dysfunction.
Methods
From 1997 to 2004, a total of 63 patients who had valvular disease with moderate or severe tricuspid regurgitation were studied. In addition to the indocyanine green retention rate at 15 min (ICG15) and the Child-Pugh score, we measured serum total bilirubin (T-bil), asparate aminotransferase (AST), alanine aminotransferase (ALT), cholinesterase (ChE), albumin (Alb) concentration, and prothrombin time. We compared these preoperative factors with postoperative liver dysfunction and mortality and attempted to develop a new liver function score.
Results
There were eight in-hospital deaths (13%). Seventeen patients had postoperative liver dysfunction. The univariate analysis indicated there were significant differences in preoperative T-bil, Alb, ChE, ICG15, and Child-Pugh score between the patients with and without liver dysfunction. Multivariate logistic regression analysis also identified preoperative T-bil as a significant indicator of postoperative liver dysfunction and preoperative ChE as a predictor of mortality. Based on these findings, we introduced a liver function score to predict postoperative dysfunction and death.
Conclusion
In addition to preoperative ChE, T-bil and Alb appeared to be valuable for producing obtainable prognostic information regarding postoperative liver dysfunction in patients with severe valvular disease. A new liver score, including T-bil, ChE, and Alb, is proposed for predicting postoperative hepatic dysfunction and outcome.
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References
Toyoda Y, Okada M, Sugimoto T, Yoshida M, Ataka K, Yamashita C. Successful surgical treatment of cardiac cirrhosis: tricuspid surgery and plasma exchange. J Cardiovasc Surg 1996;37:305–307.
Kay JH. Surgical treatment of tricuspid regurgitation. Ann Thorac Surg 1992;53:1132–1133.
Watanabe Y, Kumon K. Assessment by pulse dyedensitometry indocyanine green (ICG) clearance test of hepatic function of patients before cardiac surgery: its value as a predictor of serious postoperative liver dysfunction. J Cardiothorac Vasc Anesth 1999;13:299–303.
Hirata N, Sawa Y, Matsuda H. Predictive value of preoperative serum cholinesterase concentration in patients with liver dysfunction undergoing cardiac surgery. J Card Surg 1999;14:172–177.
Chu CM, Chang CH, Liaw CH, Hsieh MJ. Jaundice after open heart surgery: a prospective study. Thorax 1984;39:52–56.
Schwertner HA, Jackson WG, Tolan G. Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin Chem 1994;40:18–23.
Pugh RWH, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1983;60:646–649.
Christensen E, Schlichting P, Fauerholdt L, Gluud C, Andersen PK, Juhl E, et al. Prognostic value of Child-Turcotte criteria in medically treated cirrhosis. Hepatology 1984;4:430–435.
Sasaki N, Shiomi S, Iwata Y, Nishiguchi S, Kuroki T, Kawabe J, et al. Clinical usefulness of scintigraphy with 99mTcgalactosyl-human serum albumin for prognosis of cirrhosis of the liver. J Nucl Med 1999;40:1652–1656.
Batin M, Wickens M, Mcentegart D, Fullwood L, Cowley AJ. The importance of abnormalities of liver function tests in predicting mortality in chronic heart failure. Eur Heart J 1995;16:1613–1618.
Kubo SH, Walter BA, John DHA, Clark M, Cody RJ. Liver function abnormalities in chronic heart failure. Arch Intern Med 1987;147:1227–1230.
Lau GT, Tan HC, Kritharides L. Type of liver dysfunction in heart failure and its relation to the severity of tricuspid regurgitation. Am J Cardiol 2002;90:1405–1409.
Takano H, Matsuda H, Kadoba K, Kawata H, Sawa Y, Shimazaki Y, et al. Monitoring of hepatic venous oxygen saturation for predicting acute liver dysfunction after Fontan operations. J Thorac Cardiovasc Surg 1994;108:700–708.
Matsuda H, Takano H, Nakano H, Shirakura R, Ohtani M, Taniguchi K, et al. Analysis of acute and chronic heart failure in view of hepatic oxygen supply-demand relationship using hepatic venous oxygen saturation. Jpn Circ J 1989;53:175–179.
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Nishi, H., Takahashi, T., Ichikawa, H. et al. Prediction of postoperative hepatic dysfunction after cardiac surgery in patients with chronic congestive heart failure. Gen Thorac Cardiovasc Surg 57, 357–362 (2009). https://doi.org/10.1007/s11748-008-0387-8
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DOI: https://doi.org/10.1007/s11748-008-0387-8