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Triple coronary artery bypass graft in a 10-year-old child with familial hypercholesterolemia

Abstract

Familial hypercholesterolemia is a genetic disorder caused by a mutation in the low density lipoprotein (LDL) receptor gene. The homozygous type of the disease is rare and causes tendon xanthomas and coronary artery disease during the early years of life. Herein we present a 10-year-old child with familial hypercholesterolemia who had three-vessel disease and was a candidate for liver transplantation. To the best of our knowledge, he is one of the youngest such patients reported in the English-language literature who underwent coronary artery bypass surgery.

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References

  1. Wiegman A, Rodenburg J, de Jongh S, Defesche JC, Bakker HD, Kastelein JJ, et al. Family history and cardiovascular risk in familial hypercholesterolemia: data in more than 1000 children. Circulation 2003;107:1473–1478.

    PubMed  Article  Google Scholar 

  2. Kawasuji M, Sakakibara N, Fujii S, Yasuda T, Watanabe Y. Coronary artery bypass surgery with arterial grafts in familial hypercholesterolemia. J Thorac Cardiovasc Surg 2000;119:1008–1013.

    PubMed  Article  CAS  Google Scholar 

  3. Sibley C, McGann S, Stone NJ. Long-term survival of childhood coronary artery disease in a patient severely affected with familial hypercholesterolemia. Am J Cardiol 2004;94:699–700.

    PubMed  Article  Google Scholar 

  4. Bilal MS, Aydemir NA, Cine N, Celebi A, Kaplan M. Triple coronary bypass in a child with homozygous familial hypercholesterolemia. Heart Surg Forum 2005;8:E351–E353.

    PubMed  Article  Google Scholar 

  5. Ullah M, Ahmad SA. Familial hypercholesterolemia in a pediatric patient. J Coll Physicians Surg Pak 2005;15:578–579.

    PubMed  Google Scholar 

  6. Austin MA, Hutter CM, Zimmern RL, Humphries SE. Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review. Am J Epidemiol 2004;160:407–420.

    PubMed  Article  Google Scholar 

  7. Takahashi T, Nakano S, Shimazaki Y, Kaneko M, Hirata N, Nakamura T, et al. Long-term appraisal of coronary bypass operations in familial hypercholesterolemia. Ann Thorac Surg 1993;56:499–505.

    PubMed  CAS  Article  Google Scholar 

  8. Ersoy U, Güvener M. Coronary revascularization in sevenyear-old boy with homozygous familial hypercholesterolaemia. Acta Paediatr 2000;89:1501–1502.

    PubMed  Article  CAS  Google Scholar 

  9. El-Khouri HM, Danilowicz DA, Slovis AJ, Colvin SB, Artman M. Saphenous vein graft growth 13 years after coronary bypass in a child with Kawasaki disease. Ann Thorac Surg 1998;65:1127–1130.

    PubMed  Article  CAS  Google Scholar 

  10. Bhan A, Swain S, Juneja R, Saxena P, Venugopal P. Total arterial revascularization in a child with familial homozygous hypercholesterolemia. J Thorac Cardiovasc Surg 2005;129:932–934.

    PubMed  Article  Google Scholar 

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Correspondence to Mohammad Hassan Nemati.

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Nemati, M.H., Astaneh, B. & Joubeh, A. Triple coronary artery bypass graft in a 10-year-old child with familial hypercholesterolemia. Gen Thorac Cardiovasc Surg 57, 94–97 (2009). https://doi.org/10.1007/s11748-008-0335-7

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  • DOI: https://doi.org/10.1007/s11748-008-0335-7

Key words

  • Coronary artery bypass grafts
  • Pediatric
  • Hypercholesterolemia