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Prognosis of smokers following resection of pathological stage I non-small-cell lung carcinoma

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Abstract

Objective

Many patients who undergo surgery for non-small-cell lung cancer (NSCLC) have a smoking habit, which is a risk factor for NSCLC and chronic obstructive pulmonary disease (COPD). In addition, both smoking habits and COPD has been revealed to be a prognostic indicator following surgery for NSCLC. We conducted a multicenter retrospective observational study to address these issues.

Methods

Cigarette smoking and airway obstruction severity were chosen as variables to assess overall and disease-specific survival of 169 patients with pathological stage I primary NSCLC (119 stage IA, 50 stage IB) who underwent resection in 2000.

Results

The overall 5-year survival rates were 91% for patients who had never smoked (n = 66), 88% for ex-smokers (n = 36), and 72% for current smokers (n = 67) (P = 0.04). The never-smoked group had higher ratios for the factors female, pathological IA, adenocarcinoma, and favorable airway obstruction. In a nested analysis of smokers (ex-smokers and current smokers), smoking status and age were independent factors in a multivariate analysis of disease-specific survival, whereas the degree of airway obstruction was not significant.

Conclusion

For smokers who underwent resection of p-stage I NSCLC, current smoking was an unfavorable prognostic factor in an analysis containing the degree of airway obstruction as a variable.

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Authors and Affiliations

  1. Department of Cardio-Thoracic Surgery, Dokkyo Medical University School of Medicine, 880 Kitakobayashi Mibu, Tochigi, 321-0293, Japan

    Noriyoshi Sawabata MD & Shinichiro Miyoshi MD

  2. National Kinki-Chuou Medical Center for Chest Diseases, Osaka, Japan

    Akihide Matsumura MD

  3. Osaka Prefecture Medical Center for Respiratory and Allergic Disease, Osaka, Japan

    Mitsunori Ohta MD

  4. Toneyama National Hospital, Osaka, Japan

    Hajime Maeda MD

  5. Ohtemae Hospital, Osaka, Japan

    Hirofumi Sueki MD

  6. Toyonaka City General Hospital, Osaka, Japan

    Masanobu Hayakawa MD

  7. Osaka University Graduate School of Medicine, Osaka, Japan

    Meinoshin Okumura MD & Yoshiki Sawa MD

Authors
  1. Noriyoshi Sawabata MD
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  2. Shinichiro Miyoshi MD
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  3. Akihide Matsumura MD
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  4. Mitsunori Ohta MD
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  5. Hajime Maeda MD
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  6. Hirofumi Sueki MD
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  7. Masanobu Hayakawa MD
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  8. Meinoshin Okumura MD
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  9. Yoshiki Sawa MD
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Corresponding author

Correspondence to Noriyoshi Sawabata MD.

Additional information

This work was presented at the 16th World Society of Cardio-Thoracic Surgery meeting, Ottawa, Canada, August 2006

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Sawabata, N., Miyoshi, S., Matsumura, A. et al. Prognosis of smokers following resection of pathological stage I non-small-cell lung carcinoma. Gen Thorac Cardiovasc Surg 55, 420–424 (2007). https://doi.org/10.1007/s11748-007-0159-x

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  • DOI: https://doi.org/10.1007/s11748-007-0159-x

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