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Oral cibenzoline reduces postoperative atrial fibrillation in coronary artery bypass grafting

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The Japanese Journal of Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

Abstract

Objective The objective of the present study was to investigate the effectiveness of postoperative oral administration of cibenzoline for the prevention of atrial fibrillation (AF) in coronary artery bypass grafting (CABG). Methods: A total of 39 patients who underwent isolated CABG from September 2000 to February 2001 and who took oral cibenzoline (300 mg per day for 10 days beginning immediately after surgery) were compared to 59 patients who underwent surgery in our department 8 months prior to the study and who did not take cibenzoline for incidence of postoperative AF. Exclusion criteria encompassed age (>80 years), low ejection fraction (<30%), high serum creatinine level (>2.0 mg/dL), and history of supraventricular arrhythmia with or without treatment by anti-arrhythmic drugs. Results: Postoperative AF occurred in 2 patients in the cibenzoline group (2/35, 5.7%) and 20 patients in the control group (20/59, 33.9%). There were significant differences in the incidence of postoperative AF (p=0.002). Multivariate analysis revealed that the administration of cibenzoline reduced the incidence of AF significantly, and that a large number of bypass grafts significantly contributed to postoperative AF in CABG. The number of bypass grafts was significantly larger in the cibenzoline group, indicating that cibenzoline administration significantly suppresses the incidence of AF after CABG in high-risk patients. Conclusions: Postoperative administration of oral cibenzoline for 10 days is one effective method for the prevention of AF after CABG.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan

    Kenzo Hirao MD

  2. Department of Cardiothoracic Surgery, Tokyo Medical and Dental University Graduate School of Medicine, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan

    Kazuyuki Kuriu MD, Hiroyuki Tanaka MD, Satoru Makita MD, Fusahiko Ito MD, Tomohiro Mizuno MD, Noriyuki Tabuchi MD, Hirokuni Arai MD & Makoto Sunamori MD

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  1. Kazuyuki Kuriu MD
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  2. Hiroyuki Tanaka MD
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  3. Kenzo Hirao MD
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  4. Satoru Makita MD
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  5. Fusahiko Ito MD
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  7. Noriyuki Tabuchi MD
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  8. Hirokuni Arai MD
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  9. Makoto Sunamori MD
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Read at the Fifty-fourth Annual Meeting of The Japanese Association for the Thoracic Surgery, Oral Session, Osaka October 3–5, 2001.

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Kuriu, K., Tanaka, H., Hirao, K. et al. Oral cibenzoline reduces postoperative atrial fibrillation in coronary artery bypass grafting. Jpn J Thorac Caridovasc Surg 53, 8–15 (2005). https://doi.org/10.1007/s11748-005-1002-x

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  • DOI: https://doi.org/10.1007/s11748-005-1002-x

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