Skip to main content
SpringerLink
Log in

Normalization of cancer antigen 125 after mitral valve replacement in a patient with congestive heart failure due to mitral valve endocarditis

  • Case Report
  • Published:
The Japanese Journal of Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

Abstract

A 63-year-old woman with a history of uterine cancer was admitted to our hospital with dyspnea and stroke. Echocardiography showed a huge vegetation attached to the posterior mitral leaflet with severe mitral regurgitation. Blood culture identified Streptococcus galactiae. The serum level of cancer antigen 125 (CA125) was elevated at 199.4 U/ml. Resection of infected tissue including mobile vegetation and replacement of mitral valve were performed. The postoperative course was uneventful and the patient was discharged after 4 weeks of antibiotic therapy. The values of CA125 returned to normal (less than 15 U/ml) on the 90th postoperative day. These findings have suggested that a high serum value of CA125 is a possible indicator of infection-related congestive heart failure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Bas RC Jr, Klug TL, St John E, Jenison E, Niloff JM, Lazarus H, et al. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med 1983; 309: 883–7.

    Article  Google Scholar 

  2. O’Brien TJ, Tanimoto H, Konishi I, Gee M. More than 15 years of CA125: What is known about the antigen, its structure and its function. Int J Biol Markers 1998; 13:188–95.

    PubMed  Google Scholar 

  3. Nagele H, Bahlo M, Klapdor R, Schaeperkoetter D, Rodiger W. CA125 and its relation to cardiac function. Am Heart J 1999; 137: 1044–9.

    Article  CAS  PubMed  Google Scholar 

  4. Soma L, Allen M, Tobin L, Ganster C, Bulley M, Hunt J, et al. CA-125 concentrations in patients awaiting cardiac transplantation. Clin Chem 2002; 48: 2289–90.

    CAS  PubMed  Google Scholar 

  5. Sjovall K, Nilsson B, Einhorn N. The significance of serum CA125 elevation in malignant and nonmalignant diseases. Gynecol Oncol 2002; 85: 175–8.

    Article  PubMed  Google Scholar 

  6. Seo T, Ikeda Y, Onaka H, Hayashi T, Kawaguchi K, Kotake C, et al. Usefulness of serum CA125 measurement for monitoring pericardial effusion. Jpn Cire J 1993; 57: 489–94.

    Article  CAS  Google Scholar 

  7. Tomita Y. Clinical evaluation and tissue distribution of CA125 in patients with pleural effusion (Eng abstr). Igaku Kenkyu 1989; 59: 90–6.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery II, Ehime University School of Medicine, Toon, Ehime, Japan

    Hiroki Sugishita MD, Hiroshi Imagawa MD, Kanji Kawachi MD, Shinnji Takano MD, Nobuhiro Tsunooka MD & Fumiaki Shikata MD

Authors
  1. Hiroki Sugishita MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hiroshi Imagawa MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kanji Kawachi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shinnji Takano MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nobuhiro Tsunooka MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Fumiaki Shikata MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sugishita, H., Imagawa, H., Kawachi, K. et al. Normalization of cancer antigen 125 after mitral valve replacement in a patient with congestive heart failure due to mitral valve endocarditis. Jpn J Thorac Caridovasc Surg 53, 486–489 (2005). https://doi.org/10.1007/s11748-005-0092-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11748-005-0092-9

Key words

Search

Navigation