Abstract
A 46-year-old man was referred to our hospital for the treatment of lung cancer. Computed tomography showed a well-defined tumor mass that was 50×45 mm in size and contained a trabecular pattern of calcification. Since he was diagnosed as having a primary lung adenocarcinoma (clinical stage IB), a left upper lobectomy with mediastinal lymph node dissection was performed. Histologically, the tumor was a poorly differentiated adenocarcinoma with rich fibrous stroma, in which there were island-shaped bone formation lesions. An immunohistochemical examination showed the expression of bone morphogenic protein-2 within tumor cells, which induce and stimulate bone formation. This finding may elucidate a possible mechanism of heterotopic bone formation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
McLendon RE, Roggli VL, Foster WL Jr, Becsey D. Carcinoma of the lung with osseous stromal metaplasia. Arch Pathol Lab Med 1985; 109: 1051–3.
Hara H, Iwabuchi K, Shinada J, Yoshimura H, Kameya T. Pulmonary adenocarcinoma with heterotopic bone formation. Pathol Int 2000; 50: 910–3.
Hayakawa K, Murata O, Ishizeki K, Saito Y, Hasegawa M, Yamakawa M, et al. A case of pulmonary ossified adenocacinoma with marked osteoplastic bone metastasis. Lung Cancer 1997; 18: 265–8.
Good CA, McDonald JR. Roentgenologic evidence of calcification in a peripheral bronchogenic carcinoma. Mayo Clin Proc 1956; 31: 317–21.
Fukuse T, Koh T, Okumura N, Kuwabara M, Suzuki Y. A case of primary lung cancer with stromal ossification (Eng abstr). Jpn J Lung Cancer 1990; 30: 267–72.
Tsuchiya T, Nishimura Y, Funada Y, Nakajima T, Hozumi A, Kotani Y, et al. Pulmonary adenocarcinoma with central ossification (Eng abstr). Nihon Kokyuki Gakkai Zasshi 2000; 38: 283–7.
Yoshida K, Morinaga S, Gemma A, Shimosato Y, Tsuchiya R, Eguchi K. Adenocarcinoma with stromal bone metaplasia of the lung (Eng abstr). Jpn J Lung Cancer 1988; 28: 87–92.
Hosoda H, Izumi H, Atarashi K, Shinohara N, Sunamori M. Lung adenocarcinoma with stromal ossification (Eng abstr). Jpn J Lung Cancer 2002; 42: 51–4.
Cooney T, Sweeney EC, Luke D. Pulmonary carcinoid tumours: A comparative regional study. J Clin Pathol 1979; 32: 1100–9.
Hanada K, Dennis JE, Caplan AI. Stimulatory effects of basic fibroblast growth factor and bone morphogenic protein-2 on osteogenic differentiation of rat bone marrow derived mesenchymal stem cells. J Bone Miner Res 1997; 12: 1606–14.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Usami, N., Yoshioka, H., Mori, S. et al. Primary lung adenocarcinoma with heterotopic bone formation. Jpn J Thorac Caridovasc Surg 53, 102–105 (2005). https://doi.org/10.1007/s11748-005-0010-1
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s11748-005-0010-1