Abstract
We report a case of herpes simplex viral (HSV) pneumonia as a post-CABG pulmonary complication in a 70-year-old man. Chest radiography on postoperative day 9, showed a glass-like shadow and pleural effusion in the left lung field, and the man's condition began deteriorating rapidly. Bronchofiberscopy to detect the pathogen and a bronchoalveolar lavage with polymerase chain reaction (PCR) yielded a definitive diagnosis of HSV pneumonia. Once therapy with acyclovir was begun, his condition improved markedly. Our case suggest that 1 viral pulmonary infection should be considered as a possible cause in postoperative cardiac patients with unexplained progressive pulmonary infiltrates, and 2 DNA amplification using PCR is rapid—it can be completed within 1 day—and sensitive and specific in diagnosing such infections.
Similar content being viewed by others
References
Graham BS, Snell JD Jr. Herpes simplex virus infection of the adult lower respiratory tract. Medicine 1983; 62: 384–93.
Ramsey PG, Fife KH, Hackman RC, Meyers JD, Corey L. Herpes simplex virus pneumonia: clinical, virologic, and pathologic features in 20 patients. Ann Intern Med 1982; 97: 813–20.
Avery RK, Longworth DL. Viral pulmonary infections in thoracic and cardiovascular surgery. Semin Thorac Cardiovasc Surg 1995; 7: 88–94.
Geradts J, Warnock M, Yen TS. Use of the polymerase chain reaction in the diagnosis of unsuspected herpes simplex viral pneumonia: report of a case. Hum Pathol 1990; 21: 118–21.
Brody JI, Pickering NJ, Fink GB, Behr ED. Altered lymphocyte subsets during cardiopulmonary bypass. Am J Clin Pathol 1987; 87: 626–8.
Hisatomi K, Isomura T, Kawara T, Yamashita M, Hirano A, Yoshida H, et al. Changes in lymphocyte subsets, mitogen responsiveness, and interleukin-2 production after cardiac operations. J Thorac Cardiovasc Surg 1989; 98: 580–91.
Tajima K, Yamamoto F, Kawazoe K, Nakatani I, Sakai H, Abe T, et al. Cardiopulmonary bypass and cellular immunity: Changes in lymphocyte subsets and natural killer cell activity. Ann Thorac Surg 1993; 55: 625–30.
Misoph M, Babin-Ebell J, Schwender S, Grossmann M, Keller F, Elert O. Response of the cellular immune system to cardiopulmonary bypass in vivo. Thorac Cardiovasc Surg 1997; 45: 217–23.
Chakraborty A, Forker A, Reese H, Casey J. Tracheobronchitis and pneumonia due to herpes simplex virus (HSV) infection. Nebr Med J 1988; 73: 347–50.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Arata, Ki., Sakata, R., Iguro, Y. et al. Herpes simplex viral pneumonia after coronary artery bypass grafting. Jpn J Thorac Caridovasc Surg 51, 158–159 (2003). https://doi.org/10.1007/s11748-003-0053-0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s11748-003-0053-0