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Dietary proteins modulate the effects of fish oil on triglyceridemia in the rat

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Lipids

Abstract

Sprague-Dawley rats were fed purified diets varying in both protein (20%) and lipid (11%) content for 28 d to verify the independent and interactive effects of dietary proteins and lipids on serum and hepatic lipids, and on tissue lipoprotein lipase (LPL) activity in both fasted and postprandial states. These diets consisted of either casein-menhaden oil, casein-coconut oil, soy protein-menhaden oil (SPMO), soy protein-coconut oil, cod protein-menhaden oil, or cod protein-coconut oil. A randomized 3×2 factorial design was used. A significant protein-lipid interaction was seen on serum triglyceride levels: menhaden oil, compared with coconut oil, induced a decrease in serum triglyceride levels when combined with soy protein but not when combined with cod protein and casein. The lower serum triglyceride concentrations observed in the SPMO-fed rats could be the result of decreased hepatic triglycerides when soy protein was compared with casein and when menhaden oil was compared with coconut oil. Total LPL activity in the heart was higher in menhaden oil-fed rats than in coconut oil-fed rats in the postprandial state. The higher LPL activity in the heart could, however, explain only 10% of the reduction of serum triglycerides, contributing slightly to the lowering effects of SPMO diet on serum triglycerides. Therefore, the present results indicate that dietary proteins can modulate the effects of fish oil on triglyceridemia in the rat, and that could be mainly related to specific alterations in hepatic lipid concentrations.

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Abbreviations

CACO:

casein-coconut oil

CAMO:

casein-menhaden oil

CPCO:

cod protein-coconut oil

CPMO:

cod protein-menhaden oil

HDL:

high density lipoproteins

LDL:

low density lipoproteins

LPL:

lipoprotein lipase

P/S ratio:

polyunsaturated to saturated fatty acid ratio

SPCO:

soy protein-coconut oil

SPMO:

soy protein-menhaden oil

VLDL:

very low density lipoproteins

VLM:

vastus lateralis muscle

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Authors and Affiliations

  1. Département des Sciences des Aliments et de Nutrition, Pavillon Paul-Comtois, Faculté des Sciences de l'Agriculture et de l'Alimentation, Université Laval, G1K 7P4, Sainte-Foy, Québec, Canada

    Isabelle Demonty & Hélène Jacques

  2. Département des Sciences des Aliments et de Physiologie, Faculté de Médecine, Université Laval, G1K 7P4, Québec, Canada

    Yves Deshaies

Authors
  1. Isabelle Demonty
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  2. Yves Deshaies
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  3. Hélène Jacques
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Correspondence to Hélène Jacques.

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Demonty, I., Deshaies, Y. & Jacques, H. Dietary proteins modulate the effects of fish oil on triglyceridemia in the rat. Lipids 33, 913–921 (1998). https://doi.org/10.1007/s11745-998-0288-5

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  • DOI: https://doi.org/10.1007/s11745-998-0288-5

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