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Biliary excretion of dolichols and β-hexosaminidase—Effect of ethanol and glucagon

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Lipids

Abstract

Alcohol has been reported to increase the urinary excretion of dolichols, and urinary dolichols are suggested to be derived from the lysosomes of the renal cells. In the present study we examined the effects of alcohol and glucagon on the biliary excretion of dolichols in rats. Chronic ethanol treatment decreased both biliary dolichol and β-hexosaminidase excretion. The absolute amount of dolichol excreted into the bile correlated highly significantly with the absolute amount of biliary β-hexosaminidase. Our results indicate that biliary dolichols are—at least in part—derived from hepatic lysosomes. Decreased biliary dolichol output during chronic alcohol administration suggests that urinary and biliary dolichol excretions are regulated independently of each other.

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Abbreviations

b.w.:

body weight

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Authors and Affiliations

  1. Research Unit of Alcohol Diseases, University of Helsinki, Tukholmankatu 8F, 00290, Helsinki, Finland

    Kari Humaloja, Mikko Salaspuro & Risto P. Roine

Authors
  1. Kari Humaloja
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  2. Mikko Salaspuro
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  3. Risto P. Roine
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Correspondence to Mikko Salaspuro.

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Humaloja, K., Salaspuro, M. & Roine, R.P. Biliary excretion of dolichols and β-hexosaminidase—Effect of ethanol and glucagon. Lipids 32, 1169–1172 (1997). https://doi.org/10.1007/s11745-997-0150-9

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  • DOI: https://doi.org/10.1007/s11745-997-0150-9

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