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Comparative hypocholesterolemic effects of capybara (Hydrochoerus hydrochaeris dabbenei) oil, horse oil, and sardine oil in cholesterol-fed rats

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Lipids

Abstract

The hypocholesterolemic efficacy of various polyunsaturated fatty acids was compared in rats given cholesterol-enriched diets. Capybara oil (CO, linoleic+α-linolenic acids), horse oil (HO, α-linolenic acid), and sardine oil (SO, eicosapentaenoic+docosahexaenoic acids) were added to diets at 50 g/kg. The weight gain, food intake, and liver weight in the CO-fed group were significantly higher than those in other groups during the 6-wk experimental period. The serum total and very low density lipoprotein (VLDL)+intermediate density lipoprotein (IDL)+low density lipoprotein (LDL) cholesterol concentrations of the CO-fed and SO-fed groups were significantly lower than in the HO-fed group after 6 wk. The serum high density lipoprotein cholesterol concentration in the SO-fed group was significantly higher than that in the CO-fed and HO-fed groups. The fecal neutral sterol concentration in the CO-fed group was reduced significantly compared with the other groups, and the fecal bile acid concentration in the HO-fed group was significantly higher than that in the SO-fed group. The results of this study demonstrate that CO lowers the serum total cholesterol and VLDL+IDL+LDL-cholesterol concentrations in the presence of excess cholesterol in the diet as well as SO.

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Abbreviations

AA 20∶4n-6:

arachidonic acid

ALA 18∶3n-3:

α-linolenic acid

CO:

capybara oil

DHA 22∶6n-3:

decosahexaenoic acid

EPA 20∶5n-3:

eicosapentaenoic acid

HDL:

high density lipoprotein

HMG-CoA:

hydroxymethylglutaryl CoA

HO:

horse oil

IDL:

intermediate density lipoprotein

LA 18∶2n-6:

linoleic acid

LDL:

low density lipoprotein

PC:

phosphatidylcholine

P/S:

polyunsaturated fatty acid/saturated fatty acid

SO:

sardine oil

TG:

triacylglycerol

VLDL:

very low density lipoprotein

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Authors and Affiliations

  1. Laboratory of Radioisotope Science, Obihiro University of Agriculture and Veterinary Medicine, 080, Hokkaido, Japan

    Tsuyoshi Habaguchi

  2. Department of Bioresource Chemistry, Obihiro University of Agriculture and Veterinary Medicine, 080, Obihiro, Hokkaido, Japan

    Michihiro Fukushima, Yasuyoshi Takayama & Masuo Nakano

Authors
  1. Michihiro Fukushima
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  2. Yasuyoshi Takayama
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  3. Tsuyoshi Habaguchi
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  4. Masuo Nakano
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Fukushima, M., Takayama, Y., Habaguchi, T. et al. Comparative hypocholesterolemic effects of capybara (Hydrochoerus hydrochaeris dabbenei) oil, horse oil, and sardine oil in cholesterol-fed rats. Lipids 32, 391–395 (1997). https://doi.org/10.1007/s11745-997-0050-z

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  • DOI: https://doi.org/10.1007/s11745-997-0050-z

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