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Lipids

, 32:151 | Cite as

Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol

  • Yvette D. Burke
  • M. Jennifer Stark
  • Steven L. Roach
  • Stephanie E. Sen
  • Pamela L. Crowell
Article

Abstract

Fruits and vegetables have protective effects against many human cancers, including pancreatic cancer. Isoprenoids are one class of phytochemicals which have antitumor activity, but little is known about their effects on cancer of the pancreas. We tested the hypothesis that isoprenoids would inhibit the growth of pancreatic tumor cells. Significant (60–90%) inhibition of the anchorage-independent growth of human MIA PaCa2 pancreatic tumor cells was attained with 25 μM farnesol, 25 μM geranylgeraniol, 100 μM perillyl amine, 100 μM geraniol, or 300 μM perillyl alcohol. We then tested the relative in vivo antitumor activities of dietary farnesol, geraniol, and perilyl alcohol against transplanted PC-1 hamster pancreatic adenocarcinomas. Syrian Golden hamsters fed geraniol or farnesol at 20 g/kg diet exhibited complete inhibition of PC-1 pancreatic tumor growth. Both farnesol and geraniol were more potent than perillyl alcohol, which inhibited tumor growth by 50% at 40 g/kg diet. Neither body weights nor plasma cholesterol levels of animals consuming isoprenoid diets were significantly different from those of pair-fed controls. Thus, farnesol, geraniol, and perillyl alcohol suppress pancreatic tumor growth without significantly affecting blood cholesterol levels. These dietary isoprenoids warrant further investigation for pancreatic cancer prevention and treatment.

Keywords

Pancreatic Cancer Isoprenoids Pancreatic Tumor Monoterpene Geraniol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviation

NMR

nuclear magnetic resonance

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Copyright information

© AOCS Press 1997

Authors and Affiliations

  • Yvette D. Burke
    • 2
  • M. Jennifer Stark
    • 2
  • Steven L. Roach
    • 1
  • Stephanie E. Sen
    • 1
  • Pamela L. Crowell
    • 2
  1. 1.Department of ChemistryIndiana University-Purdue University at IndianapolisIndianapolis
  2. 2.Department of BiologyIndiana University-Purdue, University at IndianapolisIndianapolis

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