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Lipids

, Volume 51, Issue 2, pp 159–178 | Cite as

Impact of Conjugated Linoleic Acid (CLA) on Skeletal Muscle Metabolism

  • Yoo Kim
  • Jonggun Kim
  • Kwang-Youn Whang
  • Yeonhwa ParkEmail author
Review

Abstract

Conjugated linoleic acid (CLA) has garnered special attention as a food bioactive compound that prevents and attenuates obesity. Although most studies on the effects of CLA on obesity have focused on the reduction of body fat, a number of studies have demonstrated that CLA also increases lean body mass and enhances physical performances. It has been suggested that these effects may be due in part to physiological changes in the skeletal muscle, such as changes in the muscle fiber type transformation, alteration of the intracellular signaling pathways in muscle metabolism, or energy metabolism. However, the mode of action for CLA in muscle metabolism is not completely understood. The purpose of this review is to summarize the current knowledge of the effects of CLA on skeletal muscle metabolism. Given that CLA not only reduces body fat, but also improves lean mass, there is great potential for the use of CLA to improve muscle metabolism, which would have a significant health impact.

Keywords

CLA Conjugated linoleic acid Skeletal muscle metabolism Obesity Lean body mass Physical activity 

Abbreviations

ACC

Acetyl-CoA carboxylase

AMPK

AMP-activated protein kinase

BMR

Basic metabolic rate

CLA

Conjugated linoleic acid

CPT

Carnitine palmitoyltransferase

ERR

Estrogen-related receptor

FOXO

Forkhead box O

GLUT4

Glucose transporter type 4

IL-6

Interleukin 6

LPL

Lipoprotein lipase

MEF2

Myocyte enhancer factor 2

MHC

Myosin heavy chain

NFκB

Nuclear factor kappa-light-chain-enhancer of activated B cells

NRF

Nuclear respiratory factor

PGC-1α

Peroxisome proliferator-activated receptor γ coactivator 1α

PPARδ

Peroxisome proliferator-activated receptor δ

RMR

Resting metabolic rate

SIRT1

Silent information regulator two protein 1

TAG

Triglyceride

TNF-α

Tumor necrosis factor α

UCP

Uncoupling protein

Notes

Acknowledgments

The authors thank Ms. Jayne M. Storkson for help preparing this manuscript and Dr. Deborah J. Good at the Virginia Polytechnic Institute and State University for providing Nhlh-2 knockout animals. This material is based on work supported in part by the National Institute of Food and Agriculture, U.S. Department of Agriculture, the Massachusetts Agricultural Experimental Station, and the Department of Food Science under Project No. MAS00998 and MAS00450. Yoo Kim was supported in part by the Charm Sciences scholarship from the Department of Food Science, University of Massachusetts, Amherst. Dr. Yeonhwa Park is one of the inventors of CLA use patents assigned to the Wisconsin Alumni Research Foundation.

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Copyright information

© AOCS 2016

Authors and Affiliations

  • Yoo Kim
    • 1
  • Jonggun Kim
    • 2
  • Kwang-Youn Whang
    • 2
  • Yeonhwa Park
    • 1
    Email author
  1. 1.Department of Food ScienceUniversity of MassachusettsAmherstUSA
  2. 2.Division of BiotechnologyKorea UniversitySeoulRepublic of Korea

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