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Synbiotic Food Consumption Reduces Levels of Triacylglycerols and VLDL, but not Cholesterol, LDL, or HDL in Plasma from Pregnant Women

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To our knowledge, no reports are available indicating the effects of synbiotic food consumption on blood lipid profiles and biomarkers of oxidative stress among pregnant women. This study was conducted to evaluate the effects of daily consumption of a synbiotic food on blood lipid profiles and biomarkers of oxidative stress in pregnant women. This randomized, double-blind, controlled clinical trial was performed among 52 primigravida pregnant women, aged 18 to 35-year-old at their third trimester. After a 2-week run-in period, subjects were randomly assigned to consume either a synbiotic (n = 26) or control food (n = 26) for 9 weeks. The synbiotic food consisted of a probiotic viable and heat-resistant Lactobacillus sporogenes (1 × 107 CFU) and 0.04 g inulin (HPX)/g as the prebiotic. Patients were asked to consume the synbiotic and control foods two times a day. Biochemical measurements including blood lipid profiles, plasma total antioxidant capacity (TAC) and total glutathione (GSH) were conducted before and after 9 weeks of intervention. Consumption of a synbiotic food for 9 weeks resulted in a significant reduction in serum TAG (P = 0.04), VLDL (P = 0.04) and a significant rise in plasma GSH levels (P = 0.004) compared to the control food. No significant effects of the synbiotic food consumption on serum TC, LDL, HDL and plasma TAC levels (P > 0.05) were observed. Trial registry code: IRCT201212105623N3.

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Total glutathione


High density lipoprotein


Low density lipoprotein


Monounsaturated fatty acid(s)


Polyunsaturated fatty acid


Saturated fatty acid(s)


Total antioxidant capacity




Total cholesterol


Very low density lipoprotein


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The present study was supported by a Grant (No. 9013) from the Vice-chancellor for Research, KUMS, Kashan, Iran. The authors would like to thank the staff of Naghavi and Shaheed Beheshti gynecology Clinics (Kashan, Iran) for their assistance in this project. We are grateful to the Research and Development Division of Sekkeh Gaz Company, Isfahan, Iran that provided the synbiotic product for the present study.

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None of the authors had any personal or financial conflict of interest.

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Correspondence to Zatolla Asemi.

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Taghizadeh, M., Hashemi, T., Shakeri, H. et al. Synbiotic Food Consumption Reduces Levels of Triacylglycerols and VLDL, but not Cholesterol, LDL, or HDL in Plasma from Pregnant Women. Lipids 49, 155–161 (2014).

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