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Anti-scratching Behavioral Effects of N-Stearoyl-phytosphingosine and 4-Hydroxysphinganine in Mice

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Lipids

Abstract

N-Stearoyl-phytosphingosine (SPS) and 4-hydroxysphinganine (phytosphingosine, PS), which are sphingolipids frequently found in mammalian skin, plants, and yeast, have been used as ingredients in cosmetics. In mice, treatment with SPS and PS inhibited histamine-induced scratching behavior and vascular permeability. These agents inhibited the expression of the allergic cytokines, IL-4 and TNF-α, and the activation of the transcription factors, NF-κB and c-jun, in histamine-stimulated skin tissues. These agents also showed potent anti-histamine effects in the Magnus test using guinea pig ileum. Based on these results, SPS and PS may improve scratching behavioral reactions in skin by regulating the action of histamine and the activation of the transcription factors NF-κB and c-jun.

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Abbreviations

IL:

Interleukin

NF-κB:

Nuclear factor kappaB

PS:

Phytosphingosine

SPS:

N-Stearoyl-phytosphingosine

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Authors and Affiliations

  1. Department of Life and Nanopharmaceutical Sciences, Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, 1, Hoegi, Dongdaemun-ku, Seoul, 130-701, Korea

    Kwon-Ryeol Ryu, Bomi Lee, In-Ah Lee & Dong-Hyun Kim

  2. Department of Neuroscience and Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, 158-710, Korea

    Sekwan Oh

Authors
  1. Kwon-Ryeol Ryu
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  2. Bomi Lee
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  3. In-Ah Lee
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  4. Sekwan Oh
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  5. Dong-Hyun Kim
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Correspondence to Dong-Hyun Kim.

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Ryu, KR., Lee, B., Lee, IA. et al. Anti-scratching Behavioral Effects of N-Stearoyl-phytosphingosine and 4-Hydroxysphinganine in Mice. Lipids 45, 613–618 (2010). https://doi.org/10.1007/s11745-010-3441-0

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  • DOI: https://doi.org/10.1007/s11745-010-3441-0

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