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Enhanced Bioavailability of Eicosapentaenoic Acid from Fish Oil After Encapsulation Within Plant Spore Exines as Microcapsules

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Lipids

Abstract

Benefits of eicosapentaenoic acid (EPA) can be enhanced by raising their bioavailability through microencapsulation. Pollen can be emptied to form hollow shells, known as exines, and then used to encapsulate material, such as oils in a dry powder form. Six healthy volunteers ingested 4.6 g of fish oil containing 20% EPA in the form of ethyl ester first alone and then as 1:1 microencapsulated powder of exines and fish oil. Serum bioavailability of EPA was measured by area under curve (AUC0–24). The mean AUC0–24 of EPA from ethyl ester with exine (M = 19.7, SD = 4.3) was significantly higher than ethyl ester without exines (M = 2, SD = 1.4, p < 0.01).The bioavailability of EPA is enhanced by encapsulation by pollen exines.

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Abbreviations

Ar:

Argon laser

AUC(0–24) :

Area under the curve between time 0–24 h

BHT:

Butylated hydroxytoluene

C/M:

Chloroform methanol

EPA:

Eicosapentaeoic acid

FAME:

Fatty acid methyl esters

GLC:

Gas liquid chromatography

HeNe:

Helium neon

LCPUFA:

Long chain poly unsaturated fatty acids

M:

Mean

SD:

Standard Deviation

SEM:

Scanning electron microscopy

SPSS:

Statistical Package for the Social Sciences

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Authors and Affiliations

  1. Hull Royal Infirmary, Michael White Diabetes Centre, 220-236 Anlaby Road, HU3 2RW, Hull, UK

    Ammar Wakil & Stephen L. Atkin

  2. Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK

    Grahame Mackenzie & Alberto Diego-Taboada

  3. Nutrition Group, Institute of Aquaculture, University of Stirling, Stirling, FK9 4LA, UK

    J. Gordon Bell

Authors
  1. Ammar Wakil
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  2. Grahame Mackenzie
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  3. Alberto Diego-Taboada
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  4. J. Gordon Bell
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  5. Stephen L. Atkin
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Correspondence to Ammar Wakil.

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Wakil, A., Mackenzie, G., Diego-Taboada, A. et al. Enhanced Bioavailability of Eicosapentaenoic Acid from Fish Oil After Encapsulation Within Plant Spore Exines as Microcapsules. Lipids 45, 645–649 (2010). https://doi.org/10.1007/s11745-010-3427-y

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  • DOI: https://doi.org/10.1007/s11745-010-3427-y

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