Medium- and Long-Chain Triacylglycerols Reduce Body Fat and Blood Triacylglycerols in Hypertriacylglycerolemic, Overweight but not Obese, Chinese Individuals
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In contrast to the consumption of long-chain triacylglycerols (LCT), consumption of medium- and long-chain triacylglycerols (MLCT) reduces the body fat and blood triacylglycerols (TAG) level in hypertriacylglycerolemic Chinese individuals. These responses may be affected by BMI because of obesity-induced insulin resistance. We aimed to compare the effects of consuming MLCT or LCT on reducing body fat and blood TAG level in hypertriacylglycerolemic Chinese subjects with different ranges of BMI. Employing a double-blind, randomized and controlled protocol, 101 hypertriacylglycerolemic subjects (including 67 men and 34 women) were randomly allocated to ingest 25–30 g/day MLCT or LCT oil as the only cooking oil for 8 consecutive weeks. Anthropometric measurements of body weight, BMI, body fat, WC, HC, blood biochemical variables, and subcutaneous fat area and visceral fat area in the abdomen were measured at week 0 and 8. As compared to subjects with BMI 24–28 kg/m2 in the LCT group, corresponding subjects in the MLCT group showed significantly greater decrease in body weight, BMI, body fat, WC, ratio of WC to HC, total fat area and subcutaneous fat area in the abdomen, as well as blood TAG and LDL-C levels at week 8. Based upon our results, consumption of MLCT oil may reduce body weight, body fat, and blood TAG and LDL-C levels in overweight hypertriacylglycerolemic Chinese subjects but may not induce these changes in normal or obese hypertriacylglycerolemic subjects.
KeywordsMedium-and long-chain triacylglycerols Body fat Blood triacylglycerols Hypertriacylglycerolemia Overweight Chinese Long-chain triacylglycerols
Body mass index
Medium- and long-chain triacylglycerols
Subcutaneous fat area
Total fat area
Visceral fat area
Ratio of waist circumference to hip circumference
This work was supported by the Nisshin Oillio Company. Authors are grateful to Dr. Akira Seto and Ms. Kaori Nakajima for technical support. We also gratefully acknowledge the dedicated volunteers who participated in this project.
Conflict of interest statement
None of the authors have any conflicts of interest.
- 11.Xue C, Liu Y, Wang J, Zhang R, Zhang Y, Zhang J, Zhang Y, Zheng Z, Yu X, Jing H, Nosaka N, Arai C, Kasai M, Aoyama T, Wu J (2009) Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects. Eur J Clin Nutr 63:879–886CrossRefPubMedGoogle Scholar
- 21.St-Onge MP, Jones PJ (2003) Greater rise in fat oxidation with medium-chain triglyceride consumption relative to long-chain triglyceride is associated with lower initial body weight and greater loss of subcutaneous adipose tissue. Int J Obes Relat Metab Disord 27:1565–1571CrossRefPubMedGoogle Scholar
- 22.Noguchi O, Takeuchi H, Kubota F, Tsuji H, Aoyama T (2002) Larger diet-induced thermogenesis and less body fat accumulation in rats fed medium-chain triacylglycerols than in those fed long-chain triacylglycerols. J Nutr Sci Vitaminol (Tokyo) 48:524–529Google Scholar
- 31.Takeuchi H, Kasai M, Taguchi N, Tsuji H, Suzuki M (2002) Effect of triacylglycerols containing medium- and long-chain fatty acids on serum triacylglycerol levels and body fat in college athletes. J Nutr Sci Vitaminol (Tokyo) 48:109–114Google Scholar
- 32.Takase S, Morimoto A, Nakanishi M, Muto Y (1977) Long-term effect of medium-chain triglyceride on hepatic enzymes catalyzing lipogenesis and cholesterogenesis in rats. J Nutr Sci Vitaminol (Tokyo) 23:43–51Google Scholar
- 35.Temme EH, Mensink RP, Homstra G (1997) Effects of medium chain fatty acids (MCFA), myristic acid, and oleic acid on serum lipoproteins in healthy subjects. J Lipid Res 38:1746–1754Google Scholar