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Dietary Marine-Derived Tocopherol has a Higher Biological Availability in Mice Relative to Alpha-Tocopherol

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Lipids

Abstract

The biologic availability of two kinds of tocomonoenols, marine-derived tocopherol (MDT) and α-tocomonoenol, was investigated in ICR mice. Vitamin E-deficient ICR mice were fed MDT and α-tocomonoenol together with α-tocopherol, β-tocopherol, γ-tocopherol, and δ-tocopherol, and storage in liver, spleen, lung, and brain was quantified using reverse-phase high-performance liquid chromatography. The vitamin E relative biologic availability (VE-RBA) in liver was 100 for α-tocopherol, 26 ± 3 for β-tocopherol, 4 ± 2 for γ-tocopherol, not detected for δ-tocopherol, 49 ± 6 for MDT, and 30 ± 7 for α-tocomonoenol. The VE-RBA in brain was 100 for α-tocopherol, 5 ± 2 for β-tocopherol, not detected for γ-tocopherol and δ-tocopherol, 8 ± 1 for MDT, and 4 ± 1 for α-tocomonoenol. Tocopherols and tocomonoenols did not accumulate in the spleen or lung. MDT and α-tocomonoenol had high VE-RBA values. The VE-RBA value for MDT was much higher than that for β-tocopherol.

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Abbreviations

ECD:

Electrochemical detector

FL:

Fluorescence detector

MDT:

Marine-derived tocopherol

α-TTP:

α-Tocopherol transfer protein

VEHTM:

Vitamin E homologues and tocomonoenols mixture

VE-RBA:

Vitamin E relative biologic availability

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Acknowledgments

We thank Dr. Yasukazu Yoshida for valuable comments. This work was supported by a grant from Nippon Suisan Kaisha, Ltd., Japan.

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Authors and Affiliations

  1. Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo, 108-8477, Japan

    Naohiro Gotoh, Tomiko Oka, Daisuke Mashimo & Shun Wada

  2. Department of Health Science, Kochi Women’s University, 5-15, Eikokujicho, Kochi, Kochi, 780-8515, Japan

    Hiroyuki Watanabe

  3. Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1, Meguro-ku, Tokyo, 153-8904, Japan

    Noriko Noguchi

  4. Nippon Suisan Kaisha, Ltd, 559-6, Kitano-machi, Hachioji, Tokyo, 192-0906, Japan

    Kazuhiko Hata

Authors
  1. Naohiro Gotoh
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  2. Hiroyuki Watanabe
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  3. Tomiko Oka
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  4. Daisuke Mashimo
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  6. Kazuhiko Hata
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  7. Shun Wada
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Correspondence to Shun Wada.

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Gotoh, N., Watanabe, H., Oka, T. et al. Dietary Marine-Derived Tocopherol has a Higher Biological Availability in Mice Relative to Alpha-Tocopherol. Lipids 44, 133–143 (2009). https://doi.org/10.1007/s11745-008-3257-3

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  • DOI: https://doi.org/10.1007/s11745-008-3257-3

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