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Circulating Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 are Associated with Inflammatory Markers

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Lipids

Abstract

Lectin-like oxidized-low-density lipoprotein receptor-1 (LOX-1) is increasingly linked to atherosclerotic plaque formation and the soluble form of this receptor may reflect activities of disease. We investigated the associations among levels of sLOX-1, oxidized-low-density lipoprotein (ox-LDL), cytokines and the extension of atherosclerosis in patients with coronary artery disease (CAD). Lipid, TNF-α, IL-6, C reactive protein (CRP), ox-LDL, peroxy radical and sLOX-1 levels were measured in 29 controls and 60 patients with CAD, 30 of which with one or two vessels involved (group 1), and 30 patients with three or four vessels involved (group 2). The serum levels of sLOX-1 were significantly and progressively higher in group 1 [611 (346–1,313) pg/ml, median (interquartile range)] and in group 2 [2,143 (824–3,201) pg/ml] than in control subjects [268 (111–767) pg/ml]. LOX-1 levels positively correlated with IL-6 (r = 0.38, P = 0.0042), TNF-α (r = 0.38, P = 0.0037), CRP levels (r = 0.32, P = 0.027) and age (r = 0.25, P = 0.048). In the multivariate analysis TNF-α resulted the only independent determinant of LOX-1 serum levels (β-value = 0.304, P = 0.017). These findings suggest that sLOX-1 levels are up-regulated during CAD progression and are associated with inflammatory markers. The measurement of the circulating soluble form of this receptor may be potentially useful in predicting CAD progression in humans.

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Acknowledgments

The authors thank Manuela Walker for the reviewing of the English language.

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Authors and Affiliations

  1. Institute of Clinical Physiology CNR and G. Monasterio foundation, Via Moruzzi, 1, 56124, Pisa, Italy

    Valter Lubrano, Serena Del Turco, Giuseppina Nicolini, Pietro Di Cecco & Giuseppina Basta

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  1. Valter Lubrano
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  2. Serena Del Turco
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  3. Giuseppina Nicolini
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  4. Pietro Di Cecco
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  5. Giuseppina Basta
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Correspondence to Giuseppina Basta.

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Lubrano, V., Del Turco, S., Nicolini, G. et al. Circulating Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 are Associated with Inflammatory Markers. Lipids 43, 945–950 (2008). https://doi.org/10.1007/s11745-008-3227-9

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  • DOI: https://doi.org/10.1007/s11745-008-3227-9

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