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A Pivotal Role of the Human Kidney in Catabolism of HDL Protein Components Apolipoprotein A-I and A-IV but not of A-II

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Lipids

Abstract

Renal handling of major HDL components was studied by analyzing urine from patients with Fanconi syndrome, a rare renal proximal tubular reabsorption failure, including dysfunction of the kidney HDL receptor, cubilin. A high urinary excretion of apolipoprotein A-I and A-IV corresponding to a major part of the metabolism of these proteins was measured. In contrast, no urinary excretion of apolipoprotein A-II which is more hydrophobic and tighter bound to HDL was found. Control urines displayed absence of the three apolipoproteins. Urinary excretion of phospholipids, triglycerides, cholesterol and cholesterol esters in patients was as low as in controls. In conclusion, these data indicate that the human kidney is a major site for filtered nascent apolipoprotein A-I and A-IV but not for HDL particles.

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Fig. 1

Abbreviations

apoA-I:

Apolipoprotein A-I

apoA-II:

Apolipoprotein A-II

apoA-IV:

Apolipoprotein A-IV

HDL:

High-density lipoprotein

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Acknowledgment

This work was supported by The Danish Medical Research Council.

Author information

Authors and Affiliations

  1. Department of Medical Biochemistry, University of Aarhus, 8000, Aarhus C, Denmark

    Jonas Heilskov Graversen, Henning Nielsen & Søren Kragh Moestrup

  2. Department of Cell biology, University of Aarhus, 8000, Aarhus C, Denmark

    Erik Ilsø Christensen

  3. Institut Pasteur, INSERM U545, Lille, France

    Graciela Castro & Abdelmejid Kandoussi

  4. Department of Clinical Biochemistry, Addenbrooke’s Hospital, Cambridge, UK

    Anthony Norden

  5. Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark

    Søren Kragh Moestrup

Authors
  1. Jonas Heilskov Graversen
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  2. Graciela Castro
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  3. Abdelmejid Kandoussi
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  4. Henning Nielsen
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  5. Erik Ilsø Christensen
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  6. Anthony Norden
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  7. Søren Kragh Moestrup
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Corresponding author

Correspondence to Jonas Heilskov Graversen.

Additional information

Abdelmejid Kandoussi: Deceased.

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Graversen, J.H., Castro, G., Kandoussi, A. et al. A Pivotal Role of the Human Kidney in Catabolism of HDL Protein Components Apolipoprotein A-I and A-IV but not of A-II. Lipids 43, 467–470 (2008). https://doi.org/10.1007/s11745-008-3169-2

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  • DOI: https://doi.org/10.1007/s11745-008-3169-2

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