Abstract
Toxic organochlorines that are present in food are lipophilic and carried by chylomicrons. We have studied the clearance of an organochlorine, hexachlorobenzene, from chylomicrons. Chylomicrons were obtained from mesenteric lymph of rats that were intraduodenally given 14C-hexachlorobenzene and 3H-triolein. The labeled chylomicrons were injected intravenously into recipient rats, and the clearance of isotopes was followed. Surprisingly, the hexachlorobenzene disappeared from the plasma more rapidly than the triolein. This unexpected result raises questions about the manner in which hexachlorobenzene is delivered to tissues. The tissue distribution of the hexachlorobenzene is consistent with its rapid uptake.
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Abbreviations
- DDT:
-
dichlorodiphenyl-trichloroethane
- HCB:
-
hexachlorobenzene
References
Koss, G., and Koransky, W. (1975) Studies on the Toxicology of Hexachlorobenzene I. Pharmacokinetics, Arch. Toxicol. 34, 203–212.
Vost, A., and Maclean, N. (1984) Hydrocarbon Transport in Chylomicrons and High-Density Lipoproteins in Rat, Lipids 19, 423–435.
Phan, C.T., Mortimer, B., Martins, I.J., and Redgrave, T.G. (1999) Plasma Clearance of Chylomicrons from Butterfat Is Not Dependent on Saturation: Studies with Butterfat Fractions and Other Fats Containing Triacylglycerols with Low or High Melting Points, Am. J. Clin. Nutr. 69, 1151–1161.
Fisk, A.T., Rosenberg, G., Cymbalisty, C.D., Stern, G.A., and Muir, D.C.G. (1999) Octanol/Water Partition Coefficients of Toxaphene Congeners Determined by the “Slow-Stirring” Method, Chemosphere 39, 2549–2562.
Huibers, P.D.T., and Katritzky, A.R. (1998) Correlation of the Aqueous Solubility of Hydrocarbons with Molecular Structure, J. Chem. Inf. Comput. Sci. 38, 283–292.
Maliwal, B.P., and Guthrie, F.E. (1982) In vitro Uptake and Transfer of Chlorinated Hydrocarbons Among Human Lipoproteins, J. Lipid Res. 23, 474–479.
Burton, M.A., and Bennett, B.G. (1987) Exposure of Man to Environmental Hexachlorobenzene (HCB)—An Exposure Commitment Assessment, Sci. Total Environ. 66, 137–146.
Toft, G., Hagmar, L., Giwercman, A., and Bonde, J.P. (2004) Epidemiological Evidence on Reproductive Effects of Persistent Organochlorines in Humans, Reprod. Toxicol. 19, 5–26.
Pelletier, C., Imbeault, P., and Tremblay, A. (2003) Energy Balance and Pollution by Organochlorines and Polychlorinated Biphenyls, Obes. Rev. 4, 17–24.
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Jandacek, R.J., Zheng, S., Yang, Q. et al. Rapid clearance of hexachlorobenzene from chylomicrons. Lipids 39, 993–995 (2004). https://doi.org/10.1007/s11745-004-1321-4
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DOI: https://doi.org/10.1007/s11745-004-1321-4