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Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue

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Lipids

Abstract

The inhibitory effects of 1,3-diacylglycerol (DAG) on diet-induced lipid accumulation in liver and abdominal adipose tissue of rats were investigated in the present study. Male Sprague-Dawley rats were given free access to diets containing 7 wt% TAG (low TAG), 20 wt% TAG (high TAG), or 20 wt% DAG (high DAG), respectively, for 8 wk. The body weight of rats in the 20% high-TAG group increased significantly, and the weights of their abdominal adipose tissue and liver also showed a significant increase compared with rats in the low-TAG group. However, the high-DAG diet resulted in both a significant reduction in body weight gain (with a decrease of 70.5%) and an increase in the ratio of abdominal fat to body weight (by 127%) compared with the high-TAG diet. As well, the liver TAG and serum TAG levels of the high-DAG group were significantly lower than those of the high-IAG group. These effects were associated with up-regulation of acyl-CoA carnitine acyltransferase (ACAT) and down-regulation of acyl-CoA DAG acyltransferase (DGAT) in the liver. However, no significant difference was observed in the activities of alanine aminotransferase and aspartate aminotransferase among the groups (P>0.05). The present results indicate that dietary DAG reduced fat accumulation in viscera and body, and these effects may be involved with up-regulation of ACAT and down-regulation of DGAT in the liver.

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Abbreviations

ACAT:

acyl-CoA carnitine acyltransferase

ACO:

acyl-CoA oxidase

ACS:

acyl-CoA synthase

ALT:

alanine aminotransferase

AST:

aspartate aminotransferase

DGAT:

acyl-CoA DAG acyltransferase

MGAT:

MAG acyltransferase

PPAR:

peroxisome proliferator-activated receptor(s)

TC:

total cholesterol

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Authors and Affiliations

  1. School of Biotechnology, Southern Yangtze University, 214036, Wuxi, P.R. China

    Xianghe Meng, Dongya Zou, Zhongping Shi, Zouying Duan & Zhonggui Mao

  2. Key Laboratory of Industrial Biotechnology, Ministry of Education, Southern Yangtze University, 214036, Wuxi, P.R. China

    Zhonggui Mao

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  1. Xianghe Meng
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  2. Dongya Zou
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  3. Zhongping Shi
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Correspondence to Zhongping Shi.

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Meng, X., Zou, D., Shi, Z. et al. Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue. Lipids 39, 37–41 (2004). https://doi.org/10.1007/s11745-004-1199-1

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  • DOI: https://doi.org/10.1007/s11745-004-1199-1

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