Skip to main content

Diets could prevent many diseases

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

The 2002 ISSFAL Meeting arranged a special evening discussion with professional dietitians about diet-tissue-disease relationships involving essential fatty acids and eicosanoids. The balance of eicosanoid precursors in human tissues differs widely, reflecting voluntary dietary choices among different groups worldwide. An empirical quantitative diet-tissue relationship fits these diverse values as well as other research reports on essential fatty acid metabolism. Information for dietitians and nutritionists about essential fatty acids and eicosanoids is also given in two distance learning web sites, http://ods.od.nih.gov/eicosanoids/ and http:// efaeducation.nih.gov/, which facilitate dietitian education and diet counseling. These sites also have an innovative, interactive diet planning software program with the empirical equation embedded in it to help evaluate personal food choices in the context of the diet-tissue-disease relationship and other widely recommended dietary advice.

This is a preview of subscription content, access via your institution.

Abbreviations

AA:

arachidonic acid

CHD:

coronary heart disease

DGLA:

di-homo-γ-linolenic acid

HUFA:

highly unsaturated fatty acids

MRFIT:

multiple risk factor intervention trial

NSAID:

non-steroidal anti-inflammatory drugs

References

  1. 1.

    Lands, W.E.M. (1979) The Biosynthesis and Metabolism of Prostaglandins, Annu. Rev. Physiol. 41, 633–652.

    Article  CAS  PubMed  Google Scholar 

  2. 2.

    Kulmacz, R.J., Pendleton, R.B., and Lands, W.E.M. (1994) Interaction Between Peroxidase and Cyclooxygenase Activities in Prostaglandin-Endoperoxide Synthase, J. Biol. Chem. 269, 5527–5536.

    CAS  PubMed  Google Scholar 

  3. 3.

    Malkowski, M.G., Thuresson, E.D., Lakkides, K.M., Rieke, C.J., Micielli, R., Smith, W.L., and Garavito, R.M. (2001) Structure of Eicosapentaenoic and Linoleic Acids in the Cyclooxygenase Site of Prostaglandin Endoperoxide H Synthase-1, J. Biol. Chem. 276, 37547–37555.

    Article  CAS  PubMed  Google Scholar 

  4. 4.

    Needleman, P., Raz, A., Minkes, M.S., Ferrendelli, J.A., and Sprecher, H. (1979) Triene Prostaglandins: Prostacyclin and Thromboxane Biosynthesis and Unique Biological Properties, Proc. Natl. Acad. Sci. USA 76, 944–948.

    Article  CAS  PubMed  Google Scholar 

  5. 5.

    Lands, W.E.M., and Samuelsson, B. (1968) Phospholipid Precursors of Prostaglandin, Biochim. Biophys. Acta 164, 426–429.

    CAS  PubMed  Google Scholar 

  6. 6.

    Mohrhauer, H., and Holman, R.T. (1963) Effect of Linolenic Acid upon the Metabolism of Linoleic Acid, J. Nutr. 81, 67–74.

    CAS  PubMed  Google Scholar 

  7. 7.

    Mohrhauer, H., and Holman, R.T. (1963) The Effect of Dose Level of Essential Fatty Acids upon Fatty Acid Composition of the Rat Liver, J. Lipid Res. 4, 151–159.

    CAS  PubMed  Google Scholar 

  8. 8.

    Harris W.S., Ginsberg, H., Arunakul, N., Shachter, N.S., Windsor, S.L., Adams, M., Berglund, L., and Osmundsen, K. (1997) Safety and Efficacy of Omacor in Severe Hypertriglyceridemia, J. Cardiovasc. Risk 4, 385–391.

    Article  CAS  PubMed  Google Scholar 

  9. 9.

    Kobayashi, M., Sasaki, S., Kawabata, T., Hasegawa, K., Akabane, M., and Tsugane, S. (2001) Single Measurement of Serum Phospholipid Fatty Acid as a Biomarker of Specific Fatty Acid Intake in Middle-Aged Japanese Men, Eur. J. Clin. Nutr. 55, 643–650.

    Article  CAS  PubMed  Google Scholar 

  10. 10.

    Lands, W.E.M., Hamazaki, T., Yamazaki, K., Okuyama, H., Sakai, K., Goto, Y., and Hubbard, V.S. (1990) Changing Dietary Patterns, Am. J. Clin. Nutr. 51, 991–993.

    CAS  PubMed  Google Scholar 

  11. 11.

    Lands, W.E.M. (1991) Biosynthesis of Prostaglandins, Annu. Rev. Nutr. 11, 41–60.

    Article  CAS  PubMed  Google Scholar 

  12. 12.

    Lands, W.E.M., Libelt, B., Morris, A., Kramer, N.C., Prewitt, T.E., Bowen, P., Schmeisser, D., Davidson, M.H., and Burns, J.H. (1992) Mamtenance of Lower Proportions of n−6 Eicosanoid Precursors in Phospholipids of Human Plasma in Response to Added Dietary n−3 Fatty Acids, Biochim. Biophys. Acta 1180, 147–162.

    CAS  PubMed  Google Scholar 

  13. 13.

    Dolecek, T.A., and Granditis, G. (1991) Dietary Polyunsaturated Fatty Acids and Mortality in the Multiple Risk Factor Intervention Trial (MRFIT), World Rev. Nutr. Diet. 66, 205–216.

    CAS  PubMed  Google Scholar 

  14. 14.

    Dewailly, E., Blanchet, C., Lemieux, S., Sauve, L., Gingras, S., Ayotte, P., and Holub, B.J. (2002) n−3 Fatty Acids and Cardiovascular Disease Risk Factors Among the Inuit of Nunavik, Am. J. Clin. Nutr. 76, 85–92.

    CAS  PubMed  Google Scholar 

  15. 15.

    Dewailly, E., Blanchet, C., Gingras, S., Lemieux, S., and Holub, B.J. (2002) Cardiovascular Disease Risk Factors and n−3 Fatty Acid Status in the Adult Population of James Bay Cree, Am. J. Clin. Nutr. 76, 85–92.

    CAS  PubMed  Google Scholar 

  16. 16.

    Dewailly, E.E., Blanchet, C., Gingras, S., Lemieux, S., Sauve, L., Bergeron, J., and Holub, B.J. (2001) Relations Between n−3 Fatty Acid Status and Cardiovascular Disease Risk Factors Among Quebecers, Am. J. Clin. Nutr. 74, 603–611.

    CAS  Google Scholar 

  17. 17.

    Simon, J.A., Hodgkins, M.L., Browner, W.S., Neuhaus, J.M., Bernert, J.T., and Hulley, S.B. (1995) Serum Fatty Acids and the Risk of Coronary Heart Disease, Am. J. Epidemiol. 142, 469–476.

    CAS  PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to William E. M. Lands.

About this article

Cite this article

Lands, W.E.M. Diets could prevent many diseases. Lipids 38, 317–321 (2003). https://doi.org/10.1007/s11745-003-1066-0

Download citation

Keywords

  • Essential Fatty Acid
  • Eicosanoid
  • Food Choice
  • Coronary Heart Disease Risk
  • Highly Unsaturated Fatty Acid