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Effects of red wine consumption on kidney FA composition

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Lipids

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Abstract

We studied the effects of red wine consumption on the FA composition of rat kidney. Four groups of adult male rats were fed a balanced diet for 10 wk. The drinking fluid was water (control), red wine, alcohol-free red wine, or ethanol (12.5%, vol/vol). FA composition, lipid peroxidation, and cytochrome P450 content were determined in the kidney. The antioxidant capacity of plasma was also measured. Ethanol decreased the content of long-chain PUFA, whereas red wine maintained the levels of arachidonic (20∶4n−6) and eicosapentaenoic (20∶5n−3) acids and alcohol-free red wine significantly increased the levels of 20∶4n−6. Lipid peroxidation in the red wine and alcohol-free red wine groups was significantly lower than that of both the control and ethanol groups. The diminished renal lipid peroxidation was associated with an increased antioxidant capacity of plasma. Renal cytochrome P450 was elevated by 50% in the ethanol group and diminished by 20% in the alcohol-free red wine group. These data suggest that moderate red wine consumption could contribute to the preservation of the contents of n−3 and n−6 PUFA, particularly 20∶4n−6, in rat kidney. Although ethanol increased the content of cytochrome P450 in the kidney, this effect was eliminated by the nonalcoholic components of red wine.

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Abbreviations

FRAP:

ferric-reducing ability of plasma

LCPUFA:

long-chain PUFA

MDA:

malondialdehyde

PLA2 :

phospholipase A2

ROS:

reactive oxygen species

References

  1. Lands, W.E.M. (1986) Renewed Questions About Polyunsaturated Fatty Acids, Nutr. Rev. 44, 189–195.

    Article  PubMed  CAS  Google Scholar 

  2. Phinney, S.D., Odin, R.S., Johnson, B., and Holman, R.T. (1990) Reduced Arachidonate in Serum Phospholipids and Cholesteryl Esters Associated with Vegetarian Diets in Humans, Am. J. Clin. Nutr. 51, 385–389.

    PubMed  CAS  Google Scholar 

  3. Brenner, R.R., and Peluffo, R.O. (1969) Regulation of Unsaturated Fatty Acid Biosynthesis, Biochim. Biophys. Acta 76, 471–479.

    Google Scholar 

  4. Irazu, C.E., González-Rodriguez, S., and Brenner, R.R. (1993) Δ5-Desaturase Activity in Rat Kidney Microsomes, Mol. Cell. Biochem. 129, 31–37.

    Article  PubMed  CAS  Google Scholar 

  5. Muggli, R. (1993) Free Radical Tissue Damage: The Protective Role of Antioxidant Nutrients, in Free Radicals and Antioxidants in Nutrition (Corongiu, F., Banni, S., Dessi, M.A., and Rice-Evans, C., eds.), pp. 189–204, Richelieu Press, London.

    Google Scholar 

  6. Eder, K. (1999) The Effects of a Dietary Oxidized Oil on Lipid Metabolism in Rats, Lipids 34, 717–725.

    Article  PubMed  CAS  Google Scholar 

  7. Amet, Y., Pleé-Gautier, E., Berthou, F., Adas, F., and French, S.W. (2000) Adaptation to Chronic Ethanol Administration Emphasized by Fatty Acid Hydroxylations in Rat Liver and Kidney Microsomes, Eur. J. Nutr. 39, 270–276.

    Article  PubMed  CAS  Google Scholar 

  8. Holt, S., Reeder, B., Wilson, M., Harvey, S., Morrow, J.D., Roberts, L.J., II, and Moore, K. (1999) Increased Lipid Peroxidation in Patients with Rhabdomyolysis, Lancet 353, 1241.

    Article  PubMed  CAS  Google Scholar 

  9. Araya, J., Rodrigo, R., Orellana, M., and Rivera G. (2001) Red Wine Raises HDL and Preserves Long-Chain Polyunsaturated Fatty Acids in Rat Kidney and Erythrocytes, Br. J. Nutr. 86, 189–195.

    PubMed  CAS  Google Scholar 

  10. Lindi, C., Montorfano, G., and Marciani, P. (1998) Rat Erythrocyte Susceptibility to Lipid Peroxidation After Chronic Ethanol Intake, Alcohol 16, 311–316.

    Article  PubMed  CAS  Google Scholar 

  11. Baud, L., and Ardaillou, R. (1993) Involvement of Reactive Oxygen Species in Kidney Damage, Br. Med. Bull. 49, 621–629.

    PubMed  CAS  Google Scholar 

  12. Salem, N., and Olsson, N.U. (1997) Abnormalities in Essential Fatty Acid Status in Alcoholism, in Handbook of Essential Fatty Acid Biology, Biochemistry, Physiology and Behavioral Neurobiology (Mostofsky, D.I., and Yehuda, S., eds.), pp. 67–87, Humana Press, Totowa, NJ.

    Google Scholar 

  13. Pawlosky, R.J., and Salem, N., Jr. (1995) Ethanol Exposure Causes a Decrease in Docosahexaenoic Acid and an Increase in Docosapentaenoic Acid in Feline Brains and Retinas, Am. J. Clin. Nutr. 61, 1284–1289.

    PubMed  CAS  Google Scholar 

  14. Nervi, A.M., Peluffo, R.O., Brenner, R.R., and Leikin, A.I. (1980) Effect of Ethanol Administration on Fatty Acid Desaturations, Lipids 15, 263–268.

    PubMed  CAS  Google Scholar 

  15. Narce, M., Poisson, J.P., Bellenger, J., and Bellenger, S. (2001) Effect of Ethanol on Polyunsaturated Fatty Acid Biosynthesis in Hepatocytes from Spontaneously Hypertensive Rats, Alcohol Clin. Exp. Res. 25, 1231–1237.

    Article  PubMed  CAS  Google Scholar 

  16. Villanueva, J., Chandler, C.J., Shimasaki, N., Tang, A.B., Nakamura, M., Phinney, S.D., and Halsted, C.H. (1994) Effects of Ethanol Feeding on Liver, Kidney and Jejunal Membranes of Micropigs, Hepatology 19, 1229–1240.

    Article  PubMed  CAS  Google Scholar 

  17. Serafini, M., Malani, G., and Ferro-Luzzi, A. (1998) Alcohol-Free Red Wine Enhances Plasma Antioxidant Capacity in Humans, J. Nutr. 128, 1003–1007.

    PubMed  CAS  Google Scholar 

  18. Benzie, I.F.F., and Strain, J.J. (1996) The Ferric-Reducing Ability of Plasma (FRAP) as a Measure of Antioxidant Power: The FRAP Assay, Anal. Biochem. 239, 70–76.

    Article  PubMed  CAS  Google Scholar 

  19. Brink, N.G., Bonnichsen, R., and Theorell, H. (1954) A Modified Method for the Enzymatic Microdetermination of Ethanol, Acta Pharmacol. Toxicol. 10, 223–236.

    Article  CAS  Google Scholar 

  20. Orellana, M., Fuentes, O., Rosenbluth, H., Lara, M., and Valdés, E. (1992) Modulation of Rat Liver Peroxisomal and Microsomal Fatty Acid Oxidation by Starvation, FEBS Lett. 310, 193–196.

    Article  PubMed  CAS  Google Scholar 

  21. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951) Protein Measurement with the Folin Phenol Reagent, J. Biol. Chem. 193, 265–275.

    PubMed  CAS  Google Scholar 

  22. Omura, T., and Sato, R. (1964) The Carbon-Monoxide Binding Pigment by Liver Microsomes, J. Biol. Chem. 239, 2379–2385.

    PubMed  CAS  Google Scholar 

  23. Bligh, E.G., and Dyer, W.J. (1959) A Rapid Method of Total Lipid Extraction, Can. J. Biochem. Physiol. 37, 911–917.

    PubMed  CAS  Google Scholar 

  24. Ohkawa, H., Ohishi, N., and Yagi, K. (1979) Assay for Lipid Peroxides in Animal Tissues by Thiobarbituric Acid Reaction, Anal. Biochem. 95, 351–358.

    Article  PubMed  CAS  Google Scholar 

  25. Gómez-Tubio, A., Carreras, O., Tavares, E., and Delgado, M.J. (1999) Effect of Chronic Ethanol Consumption on Fatty Acid Profile of Heart Tissue in Rats, Alcohol Clin. Exp. Res. 23, 404–407.

    Article  PubMed  Google Scholar 

  26. Schubert, S.Y., Lansky, E.P., and Neeman, I. (1999) Antioxidant and Eicosanoid Enzyme Inhibition Properties of Pomegranate Seed Oil and Fermented Jice Flavonoids, J. Ethnopharmacol. 66, 11–17.

    Article  PubMed  CAS  Google Scholar 

  27. McDonald, M.S., Hughes, M., Burns, J., Lean, M.E.J., Matthews, D., and Crozier, A. (1998) Survey of the Free and Conjugated Myricetin and Quercetin Content of Red Wines of Different Geographical Origins, J. Agric. Food Chem. 46, 368–375.

    Article  PubMed  CAS  Google Scholar 

  28. Bassavarajappa, B.S., Cooper, T.B., and Hunglund, B.L. (1999) Effect of Chronic Ethanol Exposure on Mouse Brain Arachidonic Acid Specific Phospholipase A2, J. Neurochem. 72, 522–528.

    Article  Google Scholar 

  29. Despret, S., Dihn, L., Clement, M., and Bourre, J.M. (1992) Alteration of Δ6 Desaturase by Vitamin E in Rat Brain and Liver, Neurosci. Lett. 145, 19–22.

    Article  PubMed  CAS  Google Scholar 

  30. Hong, J., Smith, T.J., Ho, C.T., August, D.A., and Yang, C.S. (2001) Effect of Purified Green and Black Tea Polyphenols on Cyclooxygenase and Lipoxygenase-Dependent Metabolism of Arachidonic Acid in Human Colon Mucosa and Colon Tumor Tissues, Biochem. Pharmacol. 62, 1175–1183.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile

    Ramón Rodrigo & Myriam Orellana

  2. Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Independencia 1027, Casilla 13898, Correo 21, Santiago, Chile

    Julia Araya & Vanessa García

Authors
  1. Julia Araya
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  2. Ramón Rodrigo
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  3. Myriam Orellana
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  4. Vanessa García
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Correspondence to Julia Araya.

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Araya, J., Rodrigo, R., Orellana, M. et al. Effects of red wine consumption on kidney FA composition. Lipids 38, 275–279 (2003). https://doi.org/10.1007/s11745-003-1061-5

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  • DOI: https://doi.org/10.1007/s11745-003-1061-5

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