Lipids

, Volume 38, Issue 1, pp 21–24

Dietary CLA decreased weight loss and extended survival following the onset of kidney failure in NZB/W F1 mice

Articles

DOI: 10.1007/s11745-003-1026-8

Cite this article as:
Yang, M. & Cook, M.E. Lipids (2003) 38: 21. doi:10.1007/s11745-003-1026-8

Abstract

In an earlier study, we showed that feeding CLA immediately after weaning prolonged survival of NZB/W F1 mice after onset of proteinuria. In the present study, the feeding of CLA was delayed until mice had developed proteinuria. Thirty NZB/W F1 mice were fed a regular rodent chow after weaning. Urine samples were collected to detect proteinuria. Once a mouse was proteinuria positive, it was then randomly assigned to a 0.5% CLA supplement semipurified diet or a control diet (supplement 0.5% corn oil). The next proteinuria positive mouse was then assigned to the opposite diet to which the first mouse was assigned. Mice fed the control diet lost 25% more body weight (13.0 g) than mice fed the CLA diet (9.7 g). Moreover, CLA-fed mice survived an average 1.7-fold longer (148 d) than mice fed the control diet (89 d) after the onset of proteinuria. This follow-up study confirmed that dietary CLA had a beneficial effect in the autoimmune NZB/W F1 mouse. In summary, the cachectic symptom of systemic lupus erythematosus was decreased by dietary CLA and survival days were increased over control group.

Abbreviations

COX

cyclooxygenase

IL-2

interleukin-2

LPS

lipopolysaccharide

NZB/W F1

F1 hybrid of New Zealand Black and New Zealand White mice

SLE

systemic lupus erythematosus

TNF

tumor necrosis factor

TX

thromboxane

Copyright information

© AOCS Press 2003

Authors and Affiliations

  1. 1.Department of Animal SciencesUniversity of Wisconsin-MadisonMadison

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