Abstract
Steroidal dienones represent a significant class of compounds that are useful intermediates in the further functionalization of the steroid nucleus. Their chemical synthesis can be problematic owing to the lack of a simplified method of preparation and the occurrence of impurities that can be difficult to remove. We have endeavored to develop new methods of chemical synthesis of cholest-4,6-dien-3-one that would yield a product of high purity.
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Abbreviations
- Collindine:
-
2,4,6-trimethylpyridine
- DBN:
-
1,5-diazabicyclo[4.3.0]non-5-ene
- DBU:
-
1,8-diazabicyclo[5.4.0]undec-7-ene
- DDO:
-
2,3-dichloro-5,6-dicyano-1,4-benzoquinone
- DMF:
-
dimethylformamide
- NBS:
-
N-bromosuccinimide
- PCC:
-
pyridinium chlorochromate
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Parish, E.J., Sun, H., Lu, D. et al. New chemical syntheses of cholest-4,6-dien-3-one. Lipids 37, 1197–1200 (2002). https://doi.org/10.1007/s11745-002-1021-0
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DOI: https://doi.org/10.1007/s11745-002-1021-0