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Dolichol levels in younger and older rat hearts heterotopically transplanted in younger recipients

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Lipids

Abstract

Dolichol (D) levels increase dramatically in older tissue. An understanding of the exchangeability of D between tissues may be essential in order to understand the mechanism of the abnormal accumulation associated with aging. The question was investigated by the use of organ transplantation. D-poor hearts donated by 3-mon-old and D-rich by 22-mon-old male Lewis rats were transplanted heterotopically in 3-mon-old syngenic recipients, whose peripheral tissues and liver were poor in D. Native and transplanted hearts were taken 7 and 21 d after surgery. Native hearts of 3-mon- and 22-mon-old male Lewis rats served as control. D concentration and quantity were higher in older than in younger native hearts as expected. In the transplanted hearts, the quantity of D was unchanged, irrespective of the age of the donor and of the time of transplantation, whereas D concentration increased because of the remarkable disuse atrophy. No changes in D were observed in recipients’ tissues. It is concluded that dolichol is not redistributed via circulation from the transplanted heart to the tissues and liver of the younger recipient.

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Abbreviations

HHTx:

heterotopic heart transplantation

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Authors and Affiliations

  1. Dipartimento di Patologia sperimentale, Biotecnologie mediche, Infettivologia e Epidemiologia, University of Pisa, Via Roma 55, 56126, Pisa, Italy

    Gabriella Cavallini, Ilaria Parentini, Matilde Masini, Maria Pollera, Zina Gori & Ettore Bergamini

  2. Dipartmmento di Oncologia, Trapianti e Tecnologie Avanzate in Medicina, University of Pisa, Pisa, Italy

    Rossella Di Stefano & Franco Masca

  3. Azienda Ospedaliera Pisana, Pisa, Italy

    Marco Maccheroni

Authors
  1. Gabriella Cavallini
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  2. Ilaria Parentini
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  3. Rossella Di Stefano
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  4. Marco Maccheroni
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  5. Matilde Masini
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  6. Maria Pollera
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  7. Zina Gori
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  8. Franco Masca
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  9. Ettore Bergamini
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Corresponding author

Correspondence to Ettore Bergamini.

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Cavallini, G., Parentini, I., Di Stefano, R. et al. Dolichol levels in younger and older rat hearts heterotopically transplanted in younger recipients. Lipids 37, 913–916 (2002). https://doi.org/10.1007/s11745-002-0979-y

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  • DOI: https://doi.org/10.1007/s11745-002-0979-y

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