The aim of this study was to use whole-body magnetic resonance imaging (MRI) together with biochemical and anthropometric measurements to study the influence of regular moderate exercise with no dietary intervention on adipose tissue distribution in nonobese healthy women. We found significant decreases in both total (28.86±2.24 vs. 27.00±2.27 liters, P<0.05) and regional fat depots (visceral fat: 1.68±0.21 vs. 1.26±0.18 liters, P<0.01) using whole-body MRI despite no significant change in body weight, body mass index, or the waist-to-hip ratio. Interestingly, no changes in body fat content were found using anthropometry or impedance. There was a significant increase in high density lipoprotein cholesterol (1.58 ±0.06 vs. 1.66±0.08 mmol/L P<0.02) following exercise although there were no changes in other blood lipids such as triglycerides. In summary, moderate aerobic exercise over a period of 6 mon resulted in a preferential loss in visceral fat in nonobese healthy women, and this may help to explain some of the health benefits associated with regular and moderate physical activity.
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British Association of Sports and Exercise Science
body mass index
coefficient of variation
high density lipoprotein cholesterol
low density lipoprotein cholesterol
magnetic resonance imaging
nonesterified fatty acid
sex hormone-binding globulin
- VeO2 :
ventilatory oxygen equivalent
- VO2 max:
maximal rate of oxygen consumption
Folsom, A.R., Arnett, D.K., Hutchinson, R.G., Liao, F., Clegg, L.X., and Cooper, L.S. (1997) Physical Activity and Incidence of Coronary Heart Disease in Middle-Aged Women and Men, Med. Sci. Sports Exercise 29, 901–909.
Richter, E.A., Turcotte, L.P., Hespel, P., and Kiens, B. (1992) Metabolic Responses to Exercise, Diabetes Care 15, 1767–1774.
Miller, W.C., Koceja, D.M., and Hamilton, E.J. (1997) A Meta-Analysis of the Past 25 Years of Weight Loss Research Using Diet, Exercise or Diet Plus Exercise Intervention, Int. J. Obesity 21, 941–947.
Tremblay, A., Despres, J.P., Leblanc, C., and Bouchard, C. (1984) Sex Dimorphism in Fat Loss in Response to Exercise-Training, J. Obes. Wt. Reg. 3, 193–203.
Nelson, M.E., Fiatarone, M.A., Layne, J.E., Trice, I., Economos, C.D., Fielding, R.A., Ma, R., Pierson, R.N., and Evans, W.J. (1996) Analysis of Body-Composition Techniques and Models for Detecting Changes in Soft Tissue with Strength Training, Am. J. Clin. Nutr. 63, 678–686.
Treuth, M.S., Hunter, G.R., Kekes-Szabo, T., Weinsier, R.L., Goran, M.I., and Berland, L. (1995) Reduction in Intra-Abdominal Adipose Tissue After Strength Training in Older Women, J. Appl. Physiol. 78, 1425–1431.
Ross, R., Pedwell, H., and Rissanen, J. (1995) Effects of Energy Restriction and Exercise on Skeletal Muscle and Adipose Tissue in Women as Measured by Magnetic Resonance Imaging, Am. J. Clin. Nutr. 61, 1179–1185.
Ross, R., and Rissanen, J. (1994) Mobilization of Visceral and Subcutaneous Adipose Tissue in Response to Energy Restriction and Exercise, Am. J. Clin. Nutr. 60, 695–703.
Barnard, M.L., Schwieso, J.E., Thomas, E.L., Bell, J.D., Saeed, N., Frost, G., Bloom, S.R., and Hajnal, J.V. (1996) Evaluation of Magnetic Resonance Imaging Techniques for Analysis of Body Fat Distribution, NMR Biomed. 9, 156–164.
Thomas, E.L., Saeed, N., Hajnal, J.V., Brynes, A.E., Goldstone, A.P., Frost, G., and Bell, J.D. (1998) Magnetic Resonance Imaging of Total Body Fat, J. Appl. Physiol. 85, 1778–1785.
Saeed, N., Barnard, M.L., Hajnal, J.V., Thomas, E.L., Bell, J.D., and Young, I.R. (1996) Automated Fat, Bone Marrow and Bone Segmentation from MR Scans Using Knowledge-Based Image Processing, Proceedings of the Fourth Annual Meeting of the Society for Magnetic Resonance 1635, held in New York, published in Berkeley.
Shephard, R.J. (1988) PAR-Q: Physical Activity Readiness Questionnaire, Sports Med. 5, 185–195.
Borg, G. (1970) Perceived Exertion as an Indicator of Somatic Stress, Scand. J. Rehab. Med. 2, 92–98.
Physiological Testing Guidelines, 3rd edn., British Association of Sport and Exercise Sciences 1997, London.
Bingham, S.A., Gill, C., Welch, A., Day, K., Cassidy, A., Khaw, K.T., Sneyd, M.J., Key, T.J.A., Roe, L., and Day, N.E. (1994) Comparison of Dietary Assessment Methods in Nutritional Epidemiology: Weighed Records vs. 24 h Recalls, Food Frequency Questionnaire, and Estimated Records, Br. J. Nutr. 72, 619–643.
Holland, B., Welch, A.A., Unwin, I.D., Buss, D.H., Paul, A.A., and Southgate, D.A.T. (1991) McCance and Widdowsonis—The Composition of Foods, 5th rev. and extended edition, RSC and Ministry of Agriculture Fisheries and Food, UK Government, London.
Durnin, J.V.G., and Womersley, J. (1974) Body Fat Assessment from Total Body Density and Its Estimate from Skinfold Thicknesses: Measurements on 481 Men and Women Aged from 16 to 72 Years, Br. J. Nutr. 32, 77–87.
Despres, J.P., Pouliot, M.C., Moorjani, S., Nadeau, A., Tremblay, A., Lupien, P.J., Theriault, G., and Bouchard, C. (1991) Loss of Abdominal Fat and Metabolic Response to Exercise Training in Obese Women, Am. J. Physiol. 24, E159-E167.
Schwartz, R.S., Cain, K.C., Shuman, W.P., Larson, V., Stratton, J.R., Beard, J.C., Kahn, S.E., Cerqueira, M.D., and Abrass, I.B. (1992) Effect of Intensive Endurance Training on Lipoprotein Profiles in Young and Older Men, Metabolism 41, 649–654.
Rossner, S., Bo, W.J., Hiltbrandt, E., Hinson, W., Karstaedt, N., Santago, P., Sobol, W.T., and Crouse, J.R. (1990) Adipose Tissue Determinations in Cadavers—A Comparison Between Cross-Sectional Planimetry and Computed Tomography, Int. J. Obes. 14, 893–902.
Abate, N., and Garg, A. (1995) Heterogeneity in Adipose Tissue Metabolism: Causes, Implications and Management of Regional Adiposity, Prog. Lipid Res. 34, 53–70.
Kraemer, W.J., Staron, R.S., Hagerman, F.C., Hikida, R.S., Fry, A.C., Gordon, S.E., Nindl, B.C., Gothshalk, L.A., Volek, J.S., Marx, J.O., Newton, R.U., and Hakkinen, K. (1998) The Effects of Short-Term Resistance Training on Endocrine Function in Men and Women, Eur. J. Appl. Physiol. 78, 69–76.
Tremblay, A., Despres, J.P., and Bouchard, C. (1985) The Effects of Exercise Training on Energy Balance and Adipose Tissue Morphology and Metabolism, Sports Med. 2, 223–233.
Efendic, S. (1970) Catecholamines and Metabolism of Human Adipose Tissue. 3. Comparison Between the Regulation of Lipolysis in Omental and Subcutaneous Adipose Tissue, Acta Med. Scand. 187, 477–483.
Martin, M.L., and Jensen, M.D. (1991) Effects of Body Fat Distribution on Regional Lipolysis in Obesity, J. Clin. Invest. 88, 609–613.
Pan, D.A., Lillioja, S., Kriketos, A.D., Milner, M.R., Baur, L.A., Bogardus, C., Jenkins, A.B., and Storlien, L.H. (1997) Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action, Diabetes 46, 983–988.
Han, T.S., and Lean, M.E.J. (1998) Self-Reported Waist Circumference Compared with the “Waist Watcher” Tape-Measure to Identify Individuals at Increased Health Risk Through Intra-Abdominal Fat Accumulation, Br. J. Nutr. 80, 81–88.
Durstine, J.L., and Haskell, W.L. (1994) Effects of Exercise Training on Plasma Lipids and Lipoproteins, Exercise Sport Sci. Rev. 22, 477–521.
Montague, C.T., Prins, J.B., Sanders, L., Digby, J.E., and O'Rahilly, S. (1997) Depot- and Sex-Specific Differences in Human Leptin mRNA Expression: Implications for the Control of Regional Fat Distribution, Diabetes 46, 342–347.
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Louise Thomas, E., Brynes, A.E., McCarthy, J. et al. Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging. Lipids 35, 769–776 (2000). https://doi.org/10.1007/s11745-000-0584-0
- Waist Circumference
- Heart Rate Recovery
- Preferential Loss
- Marconi Medical System