Advertisement

Journal of Surfactants and Detergents

, Volume 1, Issue 2, pp 235–239 | Cite as

Safety to human skin of cocamidopropyl betaine: A mild surfactant for personal-care products

  • J. Edward Hunter
  • Joseph F. FowlerJr.
Article

Abstract

Cocamidopropyl betaine (CAPB) is a mild surfactant used in shampoos, conditioners, body washes, and other personal-care products. Several recently published case reports have suggested that CAPB may be a skin sensitizer. A 6-wk product-use study was conducted to determine whether subjects with previous positive patch tests to CAPB could use personal-care products (prototype hair shampoo, liquid handsoap, and body wash) with this surfactant without problems. Post-study patch testing suggested that amidoamine, a material used in the synthesis of CAPB and a contaminant of CAPB preparations, is a likely sensitizer. However, patch testing did not rule out the possibility that CAPB itself may be an allergen to a small number of presensitized individuals. It is recommended that CAPB with minimal levels of contamination be used for the formulation of personal-care products.

Key words

Amidoamine cocamidopropyl betaine dimethylaminopropylamine patch testing personal-care products product use testing skin allergy skin safety surfactant 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Fowler, J.F., Cocamidopropyl Betaine: The Significance of Positive Patch-Test Results in Twelve Patients, Cutis 52: 281–284 (1993).Google Scholar
  2. 2.
    Andersen, K.E., J. Roed-Petersen, and P. Kamp, Contact Allergy Related to TEA-PEG-3 Cocamide Sulphate and Cocamidopropyl Betaine in a Shampoo, Contact Derm. 11:192–193 (1984).CrossRefGoogle Scholar
  3. 3.
    Vilaplana, J., F. Grimalt, and C. Romaguera, Contact Dermatitis from Cocamidopropyl Betaine,-—Ibid. 23:274 (1990).CrossRefGoogle Scholar
  4. 4.
    Peter, C., and E. Hoting, Contact Allergy to Cocamidopropyl Betaine (CAPB),-—Ibid. 26:282–283 (1992).CrossRefGoogle Scholar
  5. 5.
    Taniguchi, S., J. Katoh, T. Hisa, M. Tabata, and T. Hamada, Shampoo Dermatitis Due to Cocamidopropyl Betaine,-—Ibid. 26:139 (1992).CrossRefGoogle Scholar
  6. 6.
    Ross, J.S., and I.R. White, Eyelid Dermatitis Due to Cocamidopropyl Betaine in an Eye Make-up Remover,-—Ibid. 25:64 (1991).CrossRefGoogle Scholar
  7. 7.
    Sertoli, A., P. Lombardi, G.M. Palleschi, M. Gola, and S. Giorgini, Tegobetaine in Contact Lens Solutions,-—Ibid. 16: 111–112 (1987).CrossRefGoogle Scholar
  8. 8.
    Cameli, N., G. Tosti, N. Venturo, and A. Tosti, Eyelid Dermatitis Due to Cocamidopropyl Betaine in a Hard Contact Lens Solution,-—Ibid. 25:261–262 (1991).CrossRefGoogle Scholar
  9. 9.
    Van Haute, N., and A. Dooms-Goossens, Shampoo Dermatitis Due to Cocobetaine and Sodium Lauryl Ether Sulphate, —Ibid. 9:169 (1983).CrossRefGoogle Scholar
  10. 10.
    Expert Panel of the Cosmetic Ingredient Review, Final Report on the Safety Assessment of Cocamidopropyl Betaine, J. Am. Coll. Toxicol. 10:33–52 (1991).Google Scholar
  11. 11.
    Fregert, S., Manual of Contact Dermatitis, 2nd edn., Year Book Medical Publisher, Chicago, 1981, p. 76.Google Scholar
  12. 12.
    Vilaplana, J., J.M. Mascaro, C. Trullas, J. Coll, C. Romaguera, C. Zemba, and C. Pelejero, Human Irritant Response to Different Qualities and Concentrations of Cocamidopropyl Betaines: A Possible Model of Paradoxical Irritant Response, Contact Derm. 26:289–294 (1992).CrossRefGoogle Scholar
  13. 13.
    Pigatto, P.D., A.S. Bigardi, and F. Cusano, Contact Dermatitis to Cocamidopropyl-Betaine Is Caused by Residual Amines: Relevance, Clinical Characteristics and Review of the Literature, Am. J. Contact Derm. 6:13–16 (1995).CrossRefGoogle Scholar
  14. 14.
    Angelini, G., C. Foti, L. Rigano, and G.A. Vena, 3-Dimethylaminopropylamine: A Key Substance in Contact Allergy to Cocamidopropylbetaine? Contact Derm. 32:96–99 (1995).CrossRefGoogle Scholar
  15. 15.
    Angelini, G., L. Rigano, C. Foti, G.A. Vena, and M. Grandolfo, Contact Allergy to Impurities in Surfactants: Amount, Chemical Structure and Carrier Effect in Reactions to 3-Dimethylaminopropylamine, —Ibid. 34:248–252 (1996).CrossRefGoogle Scholar
  16. 16.
    Kanerva, L., T. Estlander, and R. Jolanski, Occupational Allergic Contact Dermatitis from 3-Dimethylaminopropylamine in Shampoos,-—Ibid. 35:122–123 (1996).CrossRefGoogle Scholar
  17. 17.
    De Groot, A.C., H.B. van der Walle, and J.N. Weyland, Contact Allergy to Cocamidopropyl Betaine,-—Ibid. 33:419–422 (1995).CrossRefGoogle Scholar

Copyright information

© AOCS Press 1998

Authors and Affiliations

  1. 1.The Procter & Gamble Co.Sharon Woods Technical CenterCincinnati
  2. 2.Family & Occupational Dermatology, Inc.Louisville

Personalised recommendations