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Considerations about antibiotic management for community-acquired pneumonia: unmet needs and future perspectives

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References

  1. Russo A (2020) Spotlight on new antibiotics for the treatment of pneumonia. Clin Med Insights Circ Respir Pulm Med 20(14):1179548420982786. https://doi.org/10.1177/1179548420982786

    Article  Google Scholar 

  2. Prina E, Ranzani OT, Polverino E, Cillóniz C, Ferrer M, Fernandez L, Puig de la Bellacasa J, Menéndez R, Mensa J, Torres A (2015) Risk factors associated with potentially antibiotic-resistant pathogens in community-acquired pneumonia. Ann Am Thorac Soc. 12:153–60. https://doi.org/10.1513/AnnalsATS.201407-305OC

    Article  PubMed  Google Scholar 

  3. Russo A, Falcone M, Gutiérrez-Gutiérrez B, Calbo E, Almirante B, Viale PL, Oliver A, Ruiz-Garbajosa P, Gasch O, Gozalo M, Pitout J, Akova M, Peña C, Cisneros JM, Hernández-Torres A, Farcomeni A, Prim N, Origüen J, Bou G, Tacconelli E, Tumbarello M, Hamprecht A, Karaiskos I, de la Calle C, Pérez F, Schwaber MJ, Bermejo J, Lowman W, Hsueh PR, Mora-Rillo M, Rodriguez-Gomez J, Souli M, Bonomo RA, Paterson DL, Carmeli Y, Pascual A, Rodríguez-Baño J, REIPI/ESGBIS/INCREMENT investigators (2018) Predictors of outcome in patients with severe sepsis or septic shock due to extended-spectrum β-lactamase-producing Enterobacteriaceae. Int J Antimicrob Agents. 52:577–585. https://doi.org/10.1016/j.ijantimicag.2018.06.018

    Article  CAS  PubMed  Google Scholar 

  4. Shorr AF, Myers DE, Huang DB, Nathanson BH, Emons MF, Kollef MH (2013) A risk score for identifying methicillin-resistant Staphylococcus aureus in patients presenting to the hospital with pneumonia. BMC Infect Dis 13:268. https://doi.org/10.1186/1471-2334-13-268

    Article  PubMed  PubMed Central  Google Scholar 

  5. Metlay JP, Waterer GW, Long AC et al (2019) Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 200:e45–e67. https://doi.org/10.1164/rccm.201908-1581ST

    Article  PubMed  PubMed Central  Google Scholar 

  6. Guz D, McNeil R, Buchrits S, Goshen S, Gafter-Gvili A, Avni T (2023) Ceftriaxone 1 g versus 2 g per day, for the treatment of community-acquired pneumonia: a retrospective cohort study. Intern Emerg Med. https://doi.org/10.1007/s11739-023-03372-y

    Article  PubMed  Google Scholar 

  7. Telles JP, Cieslinski J, Gasparetto J, Tuon FF (2019) Efficacy of ceftriaxone 1 g daily versus 2 g daily for the treatment of community-acquired pneumonia: a systematic review with meta-analysis. Expert Rev Anti Infect Ther 17:501–510

    Article  CAS  PubMed  Google Scholar 

  8. Hasegawa S, Sada R, Yaegashi M, Morimoto K, Mori T, Abe M et al (2019) 1g versus 2 g daily intravenous ceftriaxone in the treatment of community onset pneumonia – a propensity score analysis of data from a Japanese multicenter registry. BMC Infect Dis 19:1079

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Segev S, Raz R, Rubinstein E, Shmuely H, Hassin D, Rosen N, Platau E, Ben Assuli S, Pitlik S (1995) Double-blind randomized study of 1 g versus 2 g intravenous ceftriaxone daily in the therapy of community-acquired infections. Eur J Clin Microbiol Infect Dis 14(10):851–855. https://doi.org/10.1007/BF01691490

    Article  CAS  PubMed  Google Scholar 

  10. de Klerk GJ, van Steijn JH, Lobatto S, Jaspers CA, van Veldhuizen WC, Hensing CA, Bunnik MC, Geraedts WH, Dofferhof AS, Van Den Berg J, Melis JH, Hoepelman AI (1999) A randomised, multicentre study of ceftriaxone versus standard therapy in the treatment of lower respiratory tract infections. Int J Antimicrob Agents 12(2):121–127. https://doi.org/10.1016/s0924-8579(99)00037-0

    Article  PubMed  Google Scholar 

  11. Russo A, Fusco P, Morrone HL, Trecarichi EM, Torti C (2023) New advances in management and treatment of multidrug-resistant Klebsiella pneumoniae. Expert Rev Anti Infect Ther 21(1):41–55. https://doi.org/10.1080/14787210.2023.2151435

    Article  CAS  PubMed  Google Scholar 

  12. Russo A, Olivadese V, Trecarichi EM, Torti C (2022) Bacterial ventilator-associated pneumonia in COVID-19 patients: data from the second and third waves of the pandemic. J Clin Med 11(9):2279. https://doi.org/10.3390/jcm11092279

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Russo A, Gavaruzzi F, Ceccarelli G, Borrazzo C, Oliva A, Alessandri F, Magnanimi E, Pugliese F, Venditti M (2022) Multidrug-resistant Acinetobacter baumannii infections in COVID-19 patients hospitalized in intensive care unit. Infection 50(1):83–92. https://doi.org/10.1007/s15010-021-01643-4

    Article  CAS  PubMed  Google Scholar 

  14. Falcone M, Russo A, Tiseo G, Cesaretti M, Guarracino F, Menichetti F (2021) Predictors of intensive care unit admission in patients with Legionella pneumonia: role of the time to appropriate antibiotic therapy. Infection 49(2):321–325. https://doi.org/10.1007/s15010-020-01565-7

    Article  CAS  PubMed  Google Scholar 

  15. Di Pasquale MF, Sotgiu G, Gramegna A, Radovanovic D, Terraneo S, Reyes LF, Rupp J, González Del Castillo J, Blasi F, Aliberti S, Restrepo MI, GLIMP Investigators (2019) Prevalence and etiology of community-acquired pneumonia in immunocompromised patients. Clin Infect Dis. 68(9):1482–1493. https://doi.org/10.1093/cid/ciy723

    Article  PubMed  Google Scholar 

  16. Falcone M, Russo A, Giannella M, Cangemi R, Scarpellini MG, Bertazzoni G, Alarcón JM, Taliani G, Palange P, Farcomeni A, Vestri A, Bouza E, Violi F, Venditti M (2015) Individualizing risk of multidrug-resistant pathogens in community-onset pneumonia. PLoS One 10(4):e0119528. https://doi.org/10.1371/journal.pone.0119528

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Mandell LA, Wunderink RG, Anzueto A et al (2007) Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 44(Suppl 2):S27

    Article  CAS  PubMed  Google Scholar 

  18. Musher DM, Thorner AR (2014) Community-acquired pneumonia. N Engl J Med 371:1619

    Article  CAS  PubMed  Google Scholar 

  19. Chalmers JD, Akram AR, Singanayagam A, Wilcox MH, Hill AT (2016) Risk factors for Clostridium difficile infection in hospitalized patients with community-acquired pneumonia. J Infect 73(1):45–53. https://doi.org/10.1016/j.jinf.2016.04.008

    Article  PubMed  Google Scholar 

  20. Russo A, Falcone M, Fantoni M, Murri R, Masucci L, Carfagna P, Ghezzi MC, Posteraro B, Sanguinetti M, Venditti M (2015) Risk factors and clinical outcomes of candidaemia in patients treated for Clostridium difficile infection. Clin Microbiol Infect 21(5):493.e1–4. https://doi.org/10.1016/j.cmi.2014.12.024

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, Magna Graecia’ University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy

    Sara Palma Gullì & Alessandro Russo

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  1. Sara Palma Gullì
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  2. Alessandro Russo
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Correspondence to Alessandro Russo.

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Gullì, S.P., Russo, A. Considerations about antibiotic management for community-acquired pneumonia: unmet needs and future perspectives. Intern Emerg Med 19, 9–11 (2024). https://doi.org/10.1007/s11739-023-03451-0

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