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Vascular smooth muscle cell dysfunction in patients with hemochromatosis

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References

  1. Girelli D, Busti F, Brissot P, Cabantchik I, Muckenthaler MU, Porto G (2022) Hemochromatosis classification: update and recommendations by the BIOIRON Society. Blood 139:3018–3029

    Article  CAS  Google Scholar 

  2. Dev S, Babitt JL (2017) Overview of Iron Metabolism in Health and Disease. Hemodial Int 21(Suppl 1):S6–S20. https://doi.org/10.1111/hdi.12542

    Article  Google Scholar 

  3. Sullivan JL (1981) Iron and the sex difference in heart disease risk. Lancet 1(8233):1293–1294

    Article  CAS  Google Scholar 

  4. Salonen JT, Nyyssönen K, Korpela H, Tuomilehto J, Seppänen R, Salonen R (1992) High store iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 86:803–811

    Article  CAS  Google Scholar 

  5. Sullivan JL (2009) Iron in arterial plaque: modifiable risk factor for atherosclerosis. Biochim Biophys Acta 1790(7):718–723

    Article  CAS  Google Scholar 

  6. Gaenzer H, Marschang P, Sturm W, Neumayr G, Vogel W, Patsch J, Weiss G (2002) Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis. J Am Coll Cardiol 40:2189–2194

    Article  CAS  Google Scholar 

  7. Selvaraj S, Seidelmann S, Silvestre OM, Claggett B, Ndumele CE, Cheng S, Yu B, Fernandes-Silva MM, Grove ML, Boerwinkle E, Shah AM, Solomon SD (2019) HFE H63D polymorphism and the risk for systemic hypertension, myocardial remodeling, and adverse cardiovascular events in the ARIC study. Hypertension 73:68–74

    Article  CAS  Google Scholar 

  8. Bacon BR, Adams PC, Kowdley KV, Powell LW, Tavill AS (2011) Diagnosis and management of hemochromatosis: 2011 practice guideline by the american association for the study of liver diseases. Hepatology 54:328–343

    Article  Google Scholar 

  9. De Marco F, Liguori R, Giardina MG, D’Armiento M, Angelucci E, Lucariello A, Morante R, Cimino L, Galeota-Lanza A, Tarantino G, Ascione A, Budillon G, Vecchione R, Martinelli R, Matarazzo M, De Simone V (2004) High prevalence of non-HFE gene-associated haemochromatosis in patients from southern Italy. Clin Chem Lab Med 42(1):17–24

    Article  Google Scholar 

  10. Napoli R, Guardasole V, Zarra E, D’Anna C, De Sena A, Lupoli GA, Oliviero U, Matarazzo M, Lupoli G, Saccà L (2010) Impaired endothelial- and nonendothelial-mediated vasodilation in patients with acute or chronic hypothyroidism. Clin Endocrinol 72:107–111

    Article  CAS  Google Scholar 

  11. Engberink MF Mariëlle F. Engberinka,∗, Cecile M. Povela, Jane Durgaa,b,1, Dorine W. Swinkelsc, Wim L.A.M. de Kortd, Evert G. Schoutena, Petra Verhoefa,b,2, Johanna M. Geleijnse Hemochromatosis (HFE) genotype and atherosclerosis: Increased susceptibility to iron-induced vascular damage in C282Y carriers?Atherosclerosis. 2010, 211(2):520-5.

  12. Ferrari M, Werner GS, Rieber J, Richartz BM, Sigusch HH, Brandstädt A, Mudra H, Figulla HR (2001) No influence of hemochromatosis-related gene mutations on restenosis rate in a retrospective study of 137 patients after coronary stent implantation. Int J Cardiovasc Interv 4(4):181–186

    Article  Google Scholar 

  13. Cash WJ, O’Neill S, O’Donnell ME, McCance DR, Young IS, McEneny J, McDougall NI, Callender ME (2014) Endothelial function, antioxidant status and vascular compliance in newly diagnosed HFE C282Y homozygotes. Adv Med Sci 59:28–33

    Article  Google Scholar 

  14. Vinchi F, Porto G, Simmelbauer A, Altamura S, Passos ST, Garbowski M, Silva AMN, Spaich S, Seide SE, Sparla R, Hentze MW, Muckenthaler MU (2020) Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction. Eur Heart J 41(28):2681–2695

    Article  CAS  Google Scholar 

  15. Yunker LM, Parboosingh JS, Conradson HE, Faris P, Bridge PJ, Buithieu J, Title LM, Charbonneau F, Verma S, Lonn EM, Anderson TJ (2006) The effect of iron status on vascular health. Vasc Med 11(2):85–91

    Article  Google Scholar 

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Tecce, N., Guardasole, V., Rotondo, M.C. et al. Vascular smooth muscle cell dysfunction in patients with hemochromatosis. Intern Emerg Med 18, 311–313 (2023). https://doi.org/10.1007/s11739-022-03127-1

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