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Efficacy of a new nutraceutical formulation (CHETOGERD®) in patients with nonerosive reflux disease (NERD): a prospective observational study

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Abstract

Nonerosive reflux disease (NERD) is a gastrointestinal disorder that leads to symptoms such as heartburn and regurgitation without visible esophageal mucosal injury, and it is treated with proton-pump inhibitors (PPIs). CHETOGERD® gel or orosoluble (oro) formulations—an association of natural active ingredient: hyaluronic acid, altea, malva, apple active TM, Aloe vera, l-triptophan, calcium gluconate, sodium bicarbonate, Musa paradisiaca)—may be an alternative or a coadjutant treatment in patients with NERD. The aim of the study was to evaluate, prospectively, the efficacy of CHETOGERD® gel and oro in inducing symptom’s reduction or remission, in consecutive patients with NERD. Patients were divided in two groups and treated with CHETOGERD® gel or CHETOGERD® oro, 3 sachets/day for 3 months, decreased to 1 sachet/day for other 3 months. Symptoms were evaluated at baseline, 3 and 6 months using the reflux disease questionnaire (RDQ). Symptoms’ remission was defined as reduction of retrosternal pain or burning, epigastric pain or burning, regurgitation and acid sensation in mouth. Frequency, distribution analyses and non-parametric tests were used for the statistical analysis. Results were considered statistically significant for p values < 0.05. Four hundred and twenty-three patients (M/F 240/183; mean age 50 years) were diagnosed with NERD and were consecutively enrolled. 146 patients underwent therapy with CHETOGERD® gel, while 277 were treated with CHETOGERD® oro. 108 patients from the first group and 172 patients from the second group completed follow up at 3 months, while 100 patients from each group completed follow-up at 6 months. Both formulations were able to significantly reduce the frequency and intensity of symptoms analysed with RDQ. No adverse events were reported. CHETOGERD® gel and oro are two valid alternatives to control symptoms in patients with nonerosive reflux disease.

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Acknowledgements

The authors received no financial support for the research or publication of this article.

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Authors and Affiliations

  1. Department of Surgical and Medical Sciences, Sant’Orsola Hospital, University of Bologna, Bologna, Italy

    Giulia Fiorini, Ilaria Maria Saracino, Matteo Pavoni, Laura Saccomanno & Dino Vaira

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  1. Giulia Fiorini
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  2. Ilaria Maria Saracino
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  3. Matteo Pavoni
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  4. Laura Saccomanno
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  5. Dino Vaira
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Contributions

Guarantor of the article: Professor Dino Vaira. Dino Vaira conceived the study. Dino Vaira and Giulia Fiorini included patients in the study. Matteo Pavoni Laura Saccomanno and Ilaria M. Saracino performed data management and statitstical analysis. Ilaria M. Saracino, Giulia Fiorini, Matteo Pavoni and Laura Saccomanno wrote the manuscript. All the authors critically reviewed the manuscript and approved the final version of this manuscript.

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Correspondence to Dino Vaira.

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The study was carried out according to Good Clinical practice guidelines.

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All patients signed an informed consent.

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Fiorini, G., Saracino, I.M., Pavoni, M. et al. Efficacy of a new nutraceutical formulation (CHETOGERD®) in patients with nonerosive reflux disease (NERD): a prospective observational study. Intern Emerg Med 15, 1265–1269 (2020). https://doi.org/10.1007/s11739-020-02309-z

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  • DOI: https://doi.org/10.1007/s11739-020-02309-z

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