Considerations about turmeric-associated hepatotoxicity following a series of cases occurred in Italy: is turmeric really a new hepatotoxic substance?

  • Davide DonelliEmail author
  • Michele Antonelli
  • Fabio Firenzuoli

Dear Editor,

In Italy, in the past 6 months, an outbreak of acute non-infectious cholestatic hepatitis, including severe cases, has occurred, and these events have been related to the consumption of turmeric-based dietary supplements manufactured by various producers; all of them transparently reported in the website of the Italian Ministry of Health (

This episode is understandably raising many concerns, because turmeric is a widely used spice, which has been employed as a dietary supplement for its antioxidant, digestive, anti-inflammatory, and even hepato-protective properties. The Italian system of Phyto-vigilance of the Istituto Superiore di Sanità (National Institute of Health) ( has detected 16 cases of acute hepatitis reported from several hospitals across the country, allowing authorities in charge to start with analytical tests aimed at identifying the possible cause of hepatitis. As a precautionary measure, consumers have been invited to...



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Copyright information

© Società Italiana di Medicina Interna (SIMI) 2019

Authors and Affiliations

  1. 1.Terme Di Monticelli, Monticelli TermeParmaItaly
  2. 2.Research and Innovation Center in Phytotherapy and Integrated Medicine CERFIT - Referring Center for Phytotherapy of Tuscany RegionCareggi University HospitalFlorenceItaly
  3. 3.Servizio di Consulenza in Medicina Integrativa e ComplementareReggio EmiliaItaly

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