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Endothelin-1 in hypertensive patients with ischemic heart disease

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Abstract

This study was aimed at evaluating whether transient dipyridamole-induced myocardial ischemia in hypertensive patients reflects on endothelin-1 plasma levels by comparing normotensives and hypertensives with or without stable angina. Endothelin-1 plasma levels were assessed in baseline conditions and after provocative stress test by dipyridamole. Four groups of ten age- and sex-matched subjects were retrospectively considered among patients referred for chest pain evaluation and submitted to high-dose Dipyridamole Echocardiographic-Scintigraphic combined test (DES). On the basis of DES results we considered: (1) control normotensives subjects; (2) essential hypertensives (for both groups negative result of DES); (3) essential hypertensives with stable angina; and (4) normotensives with stable angina (for both groups concordant DES detection of myocardial ischemia). Our data showed a marked post-DES increase of endothelin-1 plasma levels in hypertensives with stable angina (mean levels = 16.50 ± 4.19 pg/ml p < 0.001 vs. baseline = 9.05 ± 1.37 pg/ml) and a minor increase in stable angina pts (mean levels = 8.3 ± 1.75 pg/ml p < 0.01 vs. baseline = 6.74 ± 0.61 pg/ml) whereas non significant increase was observed both in control (mean levels = 5.09 ± 0.83 pg/ml p = n.s. vs. baseline = 4.91 ± 1.04 pg/ml) and hypertensives groups (mean levels = 6.34 ± 1.72 pg/ml p = n.s. vs. baseline = 5.95 ± 1.04 pg/ml). ET-1 involvement in hypertension-related ischemic heart disease patho-physiology appears to be considered.

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Authors and Affiliations

  1. Cardiovascular Sciences Department, Sapienza University, Rome, Italy

    Carlo Moroni, Stefano Tolone, Rosario Cassone & Carlo Gaudio

  2. Statistics, Sapienza University, Rome, Italy

    Cesare Affricano

  3. U.O.C. di Cardiologia, S. Eugenio Hospital, Rome, Italy

    Achille Gaspardone

  4. Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy

    Orazio Schillaci

  5. Laboratory Medicine, S. Eugenio Hospital, Rome, Italy

    Francesco Bondanini

Authors
  1. Carlo Moroni
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  2. Stefano Tolone
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  3. Francesco Bondanini
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  4. Orazio Schillaci
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  5. Cesare Affricano
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  8. Carlo Gaudio
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Correspondence to Carlo Moroni.

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The study has been approved by our Institutional Board, since respecting human rights.

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Moroni, C., Tolone, S., Bondanini, F. et al. Endothelin-1 in hypertensive patients with ischemic heart disease. Intern Emerg Med 14, 1119–1124 (2019). https://doi.org/10.1007/s11739-019-02095-3

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  • DOI: https://doi.org/10.1007/s11739-019-02095-3

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