Skip to main content

Weight-loss supplementation and acute liver failure: the case of Garcinia Cambogia

This is a preview of subscription content, access via your institution.

References

  1. 1.

    WHO World and Health Organization (http://www.epicentro.iss.it). Accessed 23 June 2018

  2. 2.

    Crescioli G, Lombardi N, Bettiol A (2018) Acute liver injury following Garcinia Cambogia weight loss supplementation: case-series and literature review. Intern Emerg Med 10:16

    Google Scholar 

  3. 3.

    Corey R, Werner KT, Singer et al (2016) Acute liver failure associated with Garcinia Cambogia use. Ann Hepatol 15:123–126

    Article  PubMed  Google Scholar 

  4. 4.

    Sharma T, Wong L, Tsai N (2010) Hydroxycut (herbal weight loss supplement) induced hepatotoxycity: a case report and review of literature. Hawaii Med J 69:188–190

    PubMed  PubMed Central  Google Scholar 

  5. 5.

    Skeie G, Braaten T, Hjartaker A (2009) Use of dietary supplements in the European prospective investigation into cancer and nutrition calibration study. Eur J Clin Nutr. 4:S226–S238

    Article  CAS  Google Scholar 

  6. 6.

    Danan G, Teschke (2015) RUCAM in drug and herb induced liver injury: the update. Int J Mol Sci 17(1):14

    Article  PubMed Central  CAS  Google Scholar 

  7. 7.

    Steven T, Qadri A, Zein NN (2005) Two patients with acute liver injury associated with use of herbal weight loss supplement hydroxycut. Ann Intern Med 142:477–478

    Article  Google Scholar 

  8. 8.

    Laczek J, Duncan M (2008) Three cases of acute hepatitis in patients taking Hydroxycut® bodybuilding supplement. Am J Gastroenterol 103(S1):143

    Google Scholar 

  9. 9.

    Alempijevic T, Zec S, Milosavljevic T (2017) Drug induced liver injury: do we know everything? World J Hepatol 9:491–502

    Article  PubMed  PubMed Central  Google Scholar 

  10. 10.

    Fong TL, Klontz KC, Canas-Coto et al (2010) Hepatotoxycity due to hydroxycut: a case series. Am J Gastroenterol 105:1561–1566

    Article  PubMed  Google Scholar 

  11. 11.

    Smith RJ, Bertilone C, Robertson AG (2016) Fulminant liver failure and transplantation after use of dietary supplements. Med J Aust 204:30–32

    Article  PubMed  Google Scholar 

  12. 12.

    Lunsford KE, Bodzin Reino DC et al (2016) Dangerous dietary supplements: Garcinia Cambogia associated hepatic failure requiring transplantation. World J Gastroenterol 22:10071–10076

    Article  PubMed  PubMed Central  Google Scholar 

  13. 13.

    Lucena MI, Andrade RJ, Fernández MC, Spanish Group for the Study of Drug-Induced Liver Disease (Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos (GEHAM)) et al (2006) Determinants of the clinical expression of amoxicillin-clavulanate hepatotoxicity: a prospective series from Spain. Hepatology 44:850–856

    Article  PubMed  CAS  Google Scholar 

  14. 14.

    Licata A, Minissale MG, Calvaruso V, Craxi A (2017) A focus on epidemiology of drug induced liver injury: analysis of a prospective color. Eur Rev Med Pharmacol Sci 21:112–121

    PubMed  CAS  Google Scholar 

  15. 15.

    Amadi CN, Orisake OE. Herb-induced injuries in developing nations: an update. Toxics. 2018;6

  16. 16.

    Licata A, Macaluso FS, Craxi A (2013) Herbal hepatotoxicity: a hidden epidemic. Intern Emerg Med 8:13–22

    Article  PubMed  Google Scholar 

  17. 17.

    Garcia-Cortes M, Robles Diaz M, Ortega Alonso A et al (2016) Hepatotoxicity by dietary supplements: a tabular listing and clinical characteristics. Int J Mol Sci 17:537

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. 18.

    Navarro VJ, Barnhart H, Bonkovsky et al (2014) Liver injury from herbal and dietary supplements in the US Drug induced liver injury Network. Hepatology 60:1399–1408

    Article  PubMed  PubMed Central  Google Scholar 

  19. 19.

    Zheng EX, Navarro VJ (2015) Liver injury from Herbal Dietary and weight loss supplements: a review. J Clin Transl Hepatol 3:93–98

    Article  PubMed  PubMed Central  Google Scholar 

  20. 20.

    De Smet PA (2002) Herbal remedies. N Engl J Med 347:2046–2056

    Article  PubMed  Google Scholar 

  21. 21.

    Chuah LO, Yeap K, Ho WY et al (2012) In vitro and in vivo toxicity of garcinia or hydroxycitric acid: a review. Evid Based Complement Altern Med. https://doi.org/10.1155/2012/197920

    Article  Google Scholar 

  22. 22.

    Heymsfield SB, Allison DB, Vasselli JR (1998) Garcinia Cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 280:1596–1600

    Article  PubMed  CAS  Google Scholar 

  23. 23.

    Onakpoya I, Hung SK, Perry R (2011) The use of Garcinia Cambogia extract (hydroxycitric acid) as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials. J Obes. https://doi.org/10.1155/2011/509038

    PubMed  Article  Google Scholar 

  24. 24.

    Clouatre DL, Preuss HG (2013) Hydroxycitric acid does not promote inflammation or liver toxicity. World J Gastroenterol 19:8160–8162

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  25. 25.

    Kim YJ, Choi MS, Park YB et al (2013) Garcinia Cambogia attenuates diet induced adiposity but exacerbates hepatic collagen accumulation and inflammation 2013. World J Gastroenterol 19:4689–4701

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Anna Licata.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of interest

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Licata, A., Minissale, M.G. Weight-loss supplementation and acute liver failure: the case of Garcinia Cambogia. Intern Emerg Med 13, 833–835 (2018). https://doi.org/10.1007/s11739-018-1912-0

Download citation

Keywords

  • Weight Loss Supplements
  • Garcinia Cambogia (GC)
  • Herb-induced Liver Injury (HILI)
  • Drug-Induced Liver Injury Network
  • Hydroxycitric Acid (HCA)