Internal and Emergency Medicine

, Volume 13, Issue 4, pp 463–465 | Cite as

Prophylaxis of venous thromboembolism in Internal Medicine Units: the RAMs issue

  • Antonella Tufano
  • Giovanni Di Minno

Venous thromboembolism (VTE), i.e., deep venous thrombosis (DVT) and pulmonary embolism (PE), is the third most frequent cardiovascular disorder, and is associated with a considerable disease burden. The prevalence of VTE is increasing with the growing world population and longer life expectancy [1, 2, 3, 4, 5, 6]. Acutely ill hospitalized medical patients—including those with heart failure, severe lung disease, ischaemic stroke, cancer, acute infection, and rheumatologic disease—are at medium–high risk of VTE [1, 2, 3, 4, 5, 6]. Primary pharmacological prophylaxis—begun at the time of admission and continued for the duration of stay in hospital—does not reduce the burden of VTE in such patients, in that it lowers the rate of thrombotic events and VTE-related death, with no effect on total mortality [3, 5, 6]. The net result is an unfavourable risk–benefit ratio at a population level, related, inter alia, to an inappropriate pharmacologic VTE prevention in low-risk patients and its...


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Conflict of interest

The authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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© SIMI 2018

Authors and Affiliations

  1. 1.Clinica Medica, Dipartimento di Medicina Clinica e Chirurgia, Centro di Coordinamento Regionale per le CoagulopatieUniversità degli Studi di Napoli “Federico II”NaplesItaly

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