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Early decrease of oxidative stress by non-invasive ventilation in patients with acute respiratory failure

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Abstract

Oxidative stress plays an important role in chronic respiratory diseases where the use of non-invasive ventilation seems to reduce the oxidative damage. Data on acute respiratory failure are still lacking. The aim of the study is to investigate the interplay between oxidative stress and acute respiratory failure, and the role of non-invasive ventilation in this setting. We enrolled 60 patients suffering from acute respiratory failure (PaO2/FiO2 ratio <300): 30 consecutive patients treated with non-invasive ventilation and 30 consecutive patients treated with conventional oxygen therapy. Serum levels of soluble Nox2-derived peptide (sNOX2-dp), a marker of NADPH-oxidase activation, and 8-iso-PGF2α and H2O2, markers of oxidative stress, were evaluated at baseline and after 3 h of treatment. At baseline, higher values of sNOX2-dp, 8-iso-PGF2α and H2O2 are associated with lower values of PaO2/FiO2 ratio (p < 0.001). After 3 h, serum levels of sNOX2-dp, H2O2, and 8-iso-PGF2α significantly decrease in patients treated with non-invasive ventilation, but not in patients treated with conventional oxygen therapy. Delta changes of oxidative stress parameters correlate inversely with the delta changes of PaO2/FiO2 (R = −0.623, p < 0.001 for sNOX2-dp; R = −0.428, p < 0.001 for H2O2; R = −0.548, p < 0.001 for 8-iso-PGF2α). In the acute respiratory failure setting, treatment with non-invasive ventilation reduces the levels of oxidative stress in the first hours. This reduction is associated with an improvement of PaO2/FiO2 ratio as well as in a reduction of NADPH-oxidase activity.

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Author notes

  1. Alessia Garramone and Roberto Cangemi contributed equally.

Authors and Affiliations

  1. UOC Emergency Medicine, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy

    Alessia Garramone, Emanuela Bresciani, Marco Corinti & Giuliano Bertazzoni

  2. I Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy

    Roberto Cangemi, Roberto Carnevale, Simona Bartimoccia, Francesco Violi & Pasquale Pignatelli

  3. Department of Emergency, M.G. Vannini Hospital, Rome, Italy

    Elisa Fante

  4. Respiratory Pathophysiology and Rehabilitation Unit, Policlinico Umberto I, Rome, Italy

    Marco Brunori

Authors
  1. Alessia Garramone
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  2. Roberto Cangemi
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  3. Emanuela Bresciani
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  4. Roberto Carnevale
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  5. Simona Bartimoccia
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  6. Elisa Fante
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  7. Marco Corinti
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  8. Marco Brunori
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  9. Francesco Violi
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  10. Giuliano Bertazzoni
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  11. Pasquale Pignatelli
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Corresponding author

Correspondence to Giuliano Bertazzoni.

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The authors declare that they have no conflict of interest.

Statement of human and animal rights

All procedures performed in this study involving human participants were in accordance with the ethical standard of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in this study.

Additional information

Giuliano Bertazzoni and Pasquale Pignatelli shared joint senior authorship.

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Garramone, A., Cangemi, R., Bresciani, E. et al. Early decrease of oxidative stress by non-invasive ventilation in patients with acute respiratory failure. Intern Emerg Med 13, 183–190 (2018). https://doi.org/10.1007/s11739-017-1750-5

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  • DOI: https://doi.org/10.1007/s11739-017-1750-5

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