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Vitamin K antagonists in the era of direct oral anticoagulants: is there still a room for their use?

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References

  1. Kearon C et al (2016) Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest 149(2):315–352

    Article  PubMed  Google Scholar 

  2. Keskar V et al (2017) The association of anticoagulation, ischemic stroke, and hemorrhage in elderly adults with chronic kidney disease and atrial fibrillation. Kidney Int 91(4):928–936

    Article  PubMed  Google Scholar 

  3. Dentali F et al (2012) Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature. Circulation 126(20):2381–2391

    Article  CAS  PubMed  Google Scholar 

  4. Dentali F et al (2015) Non-vitamin K oral anticoagulants in patients with pulmonary embolism: a systematic review and meta-analysis of the literature. Intern Emerg Med 10(4):507–514

    Article  PubMed  Google Scholar 

  5. Ruff CT et al (2014) Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet 383(9921):955–962

    Article  CAS  PubMed  Google Scholar 

  6. van Es N et al (2014) Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials. Blood 124(12):1968–1975

    Article  PubMed  Google Scholar 

  7. Cosmi B (2016) An update on the pharmaceutical management of thrombosis. Expert Opin Pharmacother 17(16):2149–2164

    Article  CAS  Google Scholar 

  8. Larsen TB et al (2016) Comparative effectiveness and safety of non-vitamin K antagonist oral anticoagulants and warfarin in patients with atrial fibrillation: propensity weighted nationwide cohort study. BMJ 353:i3189

    Article  PubMed  PubMed Central  Google Scholar 

  9. Ageno W et al (2016) Safety and effectiveness of oral rivaroxaban versus standard anticoagulation for the treatment of symptomatic deep-vein thrombosis (XALIA): an international, prospective, non-interventional study. Lancet Haematol 3(1):e12–e21

    Article  PubMed  Google Scholar 

  10. Staerk L et al (2017) Ischaemic and haemorrhagic stroke associated with non-vitamin K antagonist oral anticoagulants and warfarin use in patients with atrial fibrillation: a nationwide cohort study. Eur Heart J 38(12):907–915

    PubMed  Google Scholar 

  11. Palareti G et al (2017) Vitamin K antagonist therapy: changes in the treated populations and in management results in Italian anticoagulation clinics compared with those recorded 20 years ago. Intern Emerg Med. doi:10.1007/s11739-017-1678-9

  12. Rosendaal FR et al (1993) A method to determine the optimal intensity of oral anticoagulant therapy. Thromb Haemost 69(3):236–239

    CAS  PubMed  Google Scholar 

  13. Palareti G et al (1996) Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Italian Study on Complications of Oral Anticoagulant Therapy. Lancet 348(9025):423–428

    Article  CAS  PubMed  Google Scholar 

  14. Palareti G et al (1997) Thrombotic events during oral anticoagulant treatment: results of the inception-cohort, prospective, collaborative ISCOAT study: ISCOAT study group (Italian Study on Complications of Oral Anticoagulant Therapy). Thromb Haemost 78(6):1438–1443

    CAS  PubMed  Google Scholar 

  15. Bjorck F et al (2016) Outcomes in a warfarin-treated population with atrial fibrillation. JAMA Cardiol 1(2):172–180

    Article  PubMed  Google Scholar 

  16. Wallentin L, Yusuf S, Ezekowitz MD, Alings M, Flather M, Franzosi MG, Pais P, Dans A, Eikelboom J, Oldgren J, Pogue J, Reilly PA, Yang S, Connolly SJ (2010) Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. Lancet 376(9745):975–983

  17. Poli D et al (2014) A prospective validation of the SAME-TT2R 2 score: how to identify atrial fibrillation patients who will have good anticoagulation control on warfarin. Intern Emerg Med 9(4):443–447

    Article  PubMed  Google Scholar 

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Correspondence to Francesco Dentali.

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Dentali, F., Galliazzo, S., Zuretti, F. et al. Vitamin K antagonists in the era of direct oral anticoagulants: is there still a room for their use?. Intern Emerg Med 12, 1087–1089 (2017). https://doi.org/10.1007/s11739-017-1725-6

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