Internal and Emergency Medicine

, Volume 12, Issue 1, pp 69–73 | Cite as

A thrombotic storm

  • Sarah DamantiEmail author
  • Andrea Artoni
  • Tiziano Lucchi
  • Pier Mannuccio Mannucci
  • Daniela Mari
  • Luigi Bergamaschini

Case presentation

Dr. Damanti, Professor Bergamaschini

A 72-year-old woman was admitted to a Geriatric Rehabilitation Unit for prosthetic right leg training. She was a nulliparous widow without siblings. Her familiar history was negative for early cardiovascular events.

Her personal history was negative for smoking, hypercholesterolemia, diabetes and hypertension.

At the age of 21, after appendectomy, she developed a left saphenous thrombophlebitis, and since then she has suffered from chronic venous insufficiency with recurrent ulcers, often complicated by bacterial infections, for which she was treated with several antibiotics and with numerous skin grafts without achieving a complete resolution of the problem. At the age of 33, she underwent left saphenectomy, and at the age of 37 she developed a left femoral popliteal deep vein thrombosis which was treated with anticoagulants for a few months.

At the age of 64, a very wide left lower limb ulcerated lesion was investigated with a...


Atorvastatin Ticlopidine Thrombophilia Arterial Thrombosis Indeterminate Colitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Activated factor V


Activated factor VIII


Anti-centromere antibodies


Anti-nuclear antibody


Anti-neutrophil cytoplasmic antibody


Complement component 3 (C3)


Complement component 4 (C4)


Extractable nuclear antigens


Factor II


Factor V


Factor VIII


High density lipoprotein


High density lipoprotein cholesterol


Inflammatory bowel disease


Low density lipoprotein cholesterol


Prothrombin time


Activated partial thromboplastin time


Reference values


Venous thromboembolism


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

This article does not contain any studies with animals performed by any of the authors.

Informed consent

For this type of study formal consent is not required.


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Copyright information

© SIMI 2016

Authors and Affiliations

  • Sarah Damanti
    • 1
    • 2
    Email author
  • Andrea Artoni
    • 3
  • Tiziano Lucchi
    • 1
  • Pier Mannuccio Mannucci
    • 3
  • Daniela Mari
    • 1
    • 2
  • Luigi Bergamaschini
    • 4
    • 5
  1. 1.Geriatric Unit IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoMilanItaly
  2. 2.Department of Medical Sciences and Community HealthUniversità degli Studi di MilanoMilanItaly
  3. 3.A.Bianchi Bonomi Hemophilia and Thrombosis CenterFondazione IRCCS Ca’ Granda-Ospedale Maggiore PoliclinicoMilanItaly
  4. 4.Department of Biomedical and Clinical Sciences “Luigi Sacco”Università degli Studi di MilanoMilanItaly
  5. 5.A.S.P. Pio Albergo TrivulzioMilanItaly

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