Internal and Emergency Medicine

, Volume 5, Issue 4, pp 291–297 | Cite as

Prevention of cardiovascular risk by moderate alcohol consumption: epidemiologic evidence and plausible mechanisms

  • Augusto Di CastelnuovoEmail author
  • Simona Costanzo
  • Maria Benedetta Donati
  • Licia Iacoviello
  • Giovanni de Gaetano
IM - Review


An inverse association between moderate alcohol intake and cardiovascular risk, in particular coronary disease and ischemic stroke, has been shown in many epidemiologic studies. In addition, several other diseases are also known to occur less frequently in moderate drinkers than in non-drinkers, whereas excess of drinking is invariably harmful. However, some concern has been recently raised about the possibility that at all dosages the harm of alcohol could overcome its beneficial effects. We present here the epidemiologic and mechanistic evidence to support the protective effect of moderate alcohol intake against cardiovascular disease and all-cause mortality.


Alcohol Wine Vascular risk Total mortality 


Conflict of interest



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Copyright information

© SIMI 2010

Authors and Affiliations

  • Augusto Di Castelnuovo
    • 1
    Email author
  • Simona Costanzo
    • 1
  • Maria Benedetta Donati
    • 1
  • Licia Iacoviello
    • 1
  • Giovanni de Gaetano
    • 1
  1. 1.“RE ARTU” Research Laboratories, “John Paul II” Centre For High Technology Research and Education in Biomedical SciencesCatholic UniversityCampobassoItaly

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