Visceral obesity and metabolic syndrome: two faces of the same medal?
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In this review, we have analyzed the role of visceral obesity in the occurrence of metabolic syndrome (MetS). MetS is a common metabolic disorder that has been related recently to the increasing prevalence of obesity. The disorder is defined in various ways, but in the near future a new definition(s) should be applicable worldwide. The pathophysiology has been largely attributed, in the past years, to insulin resistance, although several epidemiological and pathophysiological data now indicate visceral obesity as a main factor in the occurrence of all the components of MetS. In view of this, relationships among visceral obesity, free fatty acids, dyslipidemia and insulin resistance have been reported. In addition, the effects of some adipocytokines and other proinflammatory factors produced by fat accumulation on the occurrence of MetS have been also emphasized. Accordingly, the “hypoadiponectinemia hypothesis” has been proposed as the most interesting to explain the pathophysiology of MetS. The epidemiologic, pathophysiologic and clinical data reported seem to indicate that MetS might be considered a fatal consequence of visceral obesity.
KeywordsMetabolic syndrome Visceral obesity Adipocytokines Adiponectin
Conflict of interest statement
The authors declare that they have no conflict of interest related to the publication of this manuscript.
- 1.Avogaro P, Crepaldi G (1965) Essential hyperlipidemia, obesity and diabetes. Diabetologia 1:137Google Scholar
- 4.Licata G, Corrao S, Parrinello G, Scaglione R (1996) Obesity and Cardiovascular diseases. Excerpta Med 1:5–166Google Scholar
- 5.Vague J (1947) La differenciation sexuelle, facteur determinant des formes de l’obesite. Press Med 30:339–340Google Scholar
- 10.Definition and classification of diabetes mellitus and its complications. Report of a WHO document. WHO/NCD/NCS/99. pp 31–33, 1999Google Scholar
- 11.Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285:2486–2497Google Scholar
- 22.Licata G, Volpe M, Scaglione R, Rubattu S (1994) Salt regulating hormones in young normotensive obese subjects. Effects of saline load. Hypertension 23(Suppl I):20–24Google Scholar
- 25.Galletti F, Strazzullo P (2007) Involvement of the renin-angiotensin system in obesity: older and newer patways. NMCD 17:699–674Google Scholar
- 42.Koenig W, Khuseyinova N, Baumert J, Meisinger C, Lowel H (2006) Serum concentration of adiponectin and risk of type 2 diabetes mellitus and coronary heart disease in apparently healthy middle-aged men: results from the 18-year follow-up of a large cohort from southern Germany. JACC 48:1369–1372PubMedGoogle Scholar