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Meta-analysis of acupuncture intervening exercise-induced fatigue

针刺干预运动性疲劳的Meta分析

  • Systematic Review
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Journal of Acupuncture and Tuina Science Aims and scope Submit manuscript

Abstract

Objective

To systematically evaluate the impact of acupuncture on exercise-induced fatigue (EIF).

Methods

Scopus, Springer Link, Web of Science, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Academic Journal Full-text Database (Wanfang), Chongqing VIP Database (CQVIP), and China Biology Medicine Disc (CBM) were systematically searched to identify randomized controlled trials (RCTs) studying acupuncture treatment of EIF from the inception till August 2020. The risk of bias in the included studies was assessed using the Cochrane handbook. RevMan 5.3 was used to conduct statistical analysis on the extracted data.

Results

A total of 11 RCTs were included for meta-analysis, involving 531 patients. It was revealed that acupuncture produced more significant effects in alleviating subjective fatigue [standardized mean difference (SMD)=−3.08, 95% confidence interval (CI) (−4.35, −1.81), P<0.001], increasing the hemoglobin content [weighted mean difference (WMD)=3.89, 95%CI (1.37, 6.42), P=0.003], reducing the lactate dehydrogenase content [WMD=−10.63, 95%CI (−17.67, −3.59), P=0.003], reducing the blood lactic acid content [SMD=−2.65, 95%CI (−4.47, −0.83), P=0.004], and down-regulating the levels of serum creatine kinase [SMD=−0.79, 95%CI (−1.10, −0.48), P<0.001] and blood urea nitrogen [WMD=−1.47, 95%CI (−1.84, −1.11), P<0.001] than the control groups.

Conclusion

Based on the existing evidence, acupuncture can be recognized as effective in improving EIF and is worthy of promotion in clinical settings.

摘要

目的

系统评价针刺对运动性疲劳的影响。

方法

系统检索Scopus、Springer Link、Web of Science、PubMed、Cochrane Library、中国知网(CNKI)、万方学术期刊全文数据库(Wanfang)、重庆维普数据库(CQVIP)、中国生物医学文献数据库(CBM)中关于针刺治疗运动性疲劳的随机对照试验(RCTs), 检索的时间范围是从建库至2020年8月。根据Cochrane手册对纳入文献进行风险偏倚评价, 并在数据提取后使用RevMan5.3软件进行统计学分析。

结果

共11项RCT纳入Meta分析, 总计531例患者。结果显示, 与对照组相比, 针刺在缓解主观感觉疲劳[SMD=−3.08, 95%CI (−4.35,−1.81), P<0.001], 增加血红蛋白含量[WMD=3.89, 95%CI (1.37, 6.42), P=0.003], 降低乳酸脱氢酶含量[WMD=−10.63,95%CI (−17.67, −3.59), P=0.003], 降低血乳酸含量[SMD=−2.65, 95%CI (−4.47, −0.83), P=0.004], 降低血清肌酸激酶[SMD=−0.79, 95%CI (−1.10, −0.48), P<0.001]和血尿素氮[WMD=−1.47, 95%CI (−1.84, −1.11), P<0.001]方面效果更优。

结论

基于当前证据, 可认为针刺能有效改善运动性疲劳, 值得临床推广。

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References

  1. MUANJAI P, MICKEVICIUS M, SNIEČKUS A, SIPAVIČIENĖ S, SATKUNSKIENE D, KAMANDULIS S, JONES D A. Low frequency fatigue and changes in muscle fascicle length following eccentric exercise of the knee extensors. Exp Physiol, 2020, 105(3): 502–510.

    Article  PubMed  Google Scholar 

  2. ZHANG X, XIA R, DAI B, SUN X, FU W. Effects of exercise-induced fatigue on lower extremity joint mechanics, stiffness, and energy absorption during landings. J Sports Sci Med, 2018, 17(4): 640–649.

    PubMed  PubMed Central  Google Scholar 

  3. LIM C, KIM H J, MORTON R W, HARRIS R, PHILLIPS S M, JEONG T S, KIM C K. Resistance exercise-induced changes in muscle phenotype are load dependent. Med Sci Sports Exerc, 2019, 51(12): 2578–2585.

    Article  PubMed  Google Scholar 

  4. BESSON T, ROSSI J, LE ROUX MALLOUF T, MARECHAL M, DOUTRELEAU S, VERGES S, MILLET G Y. Fatigue and recovery after single-stage versus multistage ultramarathon running. Med Sci Sports Exerc, 2020, 52(8): 1691–1698.

    Article  CAS  PubMed  Google Scholar 

  5. STAJER V, VRANES M, OSTOJIC S M. Correlation between biomarkers of creatine metabolism and serum indicators of peripheral muscle fatigue during exhaustive exercise in active men. Res Sports Med, 2020, 28(1): 147–154.

    Article  PubMed  Google Scholar 

  6. LÜ X T, LI Q L, LIU K Y. Effects of coping self-efficacy of high-level basketball athletes on their pre-competitive anxiety and psychological burnout. Wuhan Tiyu Xueyuan Xuebao, 2018, 52(11): 65–69.

    Google Scholar 

  7. FAN X M, LI A H. Research progress of traditional Chinese medicine treatment for motor neuron disease. Shiyong Zhongyi Neike Zazhi, 2019, 33(12): 101–103.

    Google Scholar 

  8. LIN Q, LUO N S, YANG C Y, FAN X Y, WANG Y, ZHOU W Z, FAN G Q. Revelation of FU’s subcutaneous needling therapy on the development of acupuncture and moxibustion. Zhongguo Zhen Jiu, 2020, 40(3): 307–314.

    PubMed  Google Scholar 

  9. ZHANG S, ZHOU P, WANG X R, MA S M, FU Q N, SHI G X, LIU C. Analysis of the factors influencing acupuncture efficacy based on neuroimaging technology. Beijing Zhongyiyao, 2016, 35(12): 1177–1179.

    Google Scholar 

  10. WANG H C, GUO X Z, WANG E G, ZHANG B R. An exploration on the essence of meridian-meridian as the resonance passageway for energy in life message. Beijing Shengwu Yixue Gongcheng, 2012, 31(6): 638–641.

    Google Scholar 

  11. WU Y C, YU Y Q, ZHANG J F. Effect of acupuncture on the ultramicrostructure of the injured lumbar nerve and inflammatory medium of rats. Zhongguo Linchuang Kangfu, 2005, 9(37): 182–184.

    CAS  Google Scholar 

  12. ANSARI N N, ALAEI P, NAGHDI S, FAKHARI Z, KOMESH S, DOMMERHOLT J. Immediate effects of dry needling as a novel strategy for hamstring flexibility: a single-blinded clinical pilot study. J Sport Rehabil, 2020, 29(2): 156–161.

    Article  PubMed  Google Scholar 

  13. HARWOOD B, SCHERER J, BROWN R E, CORNETT K M D, KENNO K A, JAKOBI J M. Neuromuscular responses of the plantar flexors to whole-body vibration. Scand J Med Sci Sports, 2017, 27(12): 1569–1575.

    Article  CAS  PubMed  Google Scholar 

  14. LI Y J, HU S. Meta-analysis of water exercises on the lower-extremity function and activities of daily living in patients with cerebral stroke. Zhongguo Kangfu Yixue Zazhi, 2019, 34(10): 1209–1215.

    Google Scholar 

  15. HISLOP A C, COLLINS N J, TUCKER K, DEASY M, SEMCIW A I. Does adding hip exercises to quadriceps exercises result in superior outcomes in pain, function and quality of life for people with knee osteoarthritis? A systematic review and meta-analysis. Br J Sports Med, 2020, 54(5): 263–271.

    Article  PubMed  Google Scholar 

  16. JIANG T, WU M, KONG L H, MENG P Y, HAO Q, CHEN Y Y, WANG X S, WANG Y S. Effect of pre-acupuncture at Neiguan (PC6) and Zusanli (ST36) on exercise-induced fatigue. Zhongguo Zhen Jiu, 2019, 39(10): 1063–1066.

    PubMed  Google Scholar 

  17. LI L Y. Efficacy and mechanism study of acupuncture combined with acupoint injection of Ci Wu Jia for exercise-induced fatigue. Shaanxi Zhongyi Xueyuan Xuebao, 2011, 34(2): 63–64.

    CAS  Google Scholar 

  18. PAN H S, LAI Q Y, FENG Y C, JIAO R Y. Study of mind-regulating acupuncture on training-induced fatigue in orienteering athletes. Xin Zhongyi, 2011, 43(7): 115–117.

    Google Scholar 

  19. HU L N, ZHENG F P, SHEN C Q, WANG R Z, TONG B Y, YOU S J. Effect of ear-point sticking therapy on blood glucose and serum testosterone in exercise-induced fatigue patients. Guangzhou Zhongyiyao Daxue Xuebao, 2019, 36(8): 1194–1198.

    Google Scholar 

  20. ZHAO J M, ZHANG S, WANG W Y. Study on action of acupuncture against sports physio-psychologic fatigue. Zhongguo Zhen Jiu, 2004, 24(8): 4–6.

    Google Scholar 

  21. LI H L, SUN Y Z. Clinical research on the effect of scalp penetration acupuncture treating exercise-induced fatigue. Zhenjiu Linchuang Zazhi, 2010, 26(4): 16–18.

    Google Scholar 

  22. WANG W Y, ZHAO J M, LIU L. Modulating effects of acupuncture on exercise-induced psychological fatigue and physiological fatigue. Jiefangjun Baojian Yixue Zazhi, 2004, 6(1): 35–37.

    Google Scholar 

  23. HE K J, WANG J H, ZHAO C J, TAO L. Effects of Lingguibafa-based acupuncture on the level of blood lactic acid after exhaustive exercise. Zhongguo Yundong Yixue Zazhi, 2013, 32(4): 313–315, 332.

    Google Scholar 

  24. LI J F. The clinical research of acupuncture and moxibustion on preventing exercise-induced fatigue. Liaoning Zhongyiyao Daxue Xuebao, 2009, 11(6): 189–190.

    Google Scholar 

  25. LAI Q Y, PAN H S, JIA J, FENG Y. Study of the impact of Jin San Zhen on the athletic ability and biochemical indexes in sportsmen. Shaanxi Zhongyi, 2011, 32(10): 1376–1377.

    Google Scholar 

  26. JIANG T. Therapeutic Effect of Pre-acupuncture at “Biaoben Acupoints Combination” on Exercise-induced Fatigue. Wuhan: Master Thesis of Hubei University of Chinese Medicine, 2020.

    Google Scholar 

  27. WANG L, SHAO Q, MA G, GONG M, NIU W, QIU J. Pedaling performance changing of elite cyclists is mainly determined by the fatigue of hamstring and vastus muscles during repeated sprint cycling exercise. Biomed Res Int, 2020, 2020: 7294820.

    PubMed  PubMed Central  Google Scholar 

  28. ABOODARDA S J, IANNETTA D, EMAMI N, VARESCO G, MURIAS J M, MILLET G Y. Effects of pre-induced fatigue vs. concurrent pain on exercise tolerance, neuromuscular performance and corticospinal responses of locomotor muscles. J Physiol, 2020, 598(2): 285–302.

    Article  CAS  PubMed  Google Scholar 

  29. LARUN L, BRURBERG K G, ODGAARD-JENSEN J, PRICE J R. Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev, 2017, 4(4): CD003200.

    PubMed  Google Scholar 

  30. TIAN F. Re-cognition of exercise-induced central and peripheral fatigue. Zhongguo Zuzhi Gongcheng Yanjiu, 2015, 19(42): 6849–6854.

    CAS  Google Scholar 

  31. WANG Y, ZHOU L, LIU Y X, CHEN L Q. Recent advance on researches of making mechanism of fatigue in the sports activities. Shanxi Shida Tiyu Xueyuan Xuebao, 2005, (4): 114–117.

  32. WERNBOM M, AAGAARD P. Muscle fibre activation and fatigue with low-load blood flow restricted resistance exercise: an integrative physiology review. Acta Physiol (Oxf), 2020, 228(1): e13302.

    Article  CAS  Google Scholar 

  33. VENHORST A, MICKLEWRIGHT D P, NOAKES T D. The psychophysiological regulation of pacing behaviour and performance fatigability during long-distance running with locomotor muscle fatigue and exercise-induced muscle damage in highly trained runners. Sports Med Open, 2018, 4(1): 29.

    Article  PubMed  PubMed Central  Google Scholar 

  34. POOLE D C, BURNLEY M, VANHATALO A, ROSSITER H B, JONES A M. Critical power: an important fatigue threshold in exercise physiology. Med Sci Sports Exerc, 2016, 48(11): 2320–2334.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. ST CLAIR GIBSON A, SWART J, TUCKER R. The interaction of psychological and physiological homeostatic drives and role of general control principles in the regulation of physiological systems, exercise and the fatigue process: the integrative governor theory. Eur J Sport Sci, 2018, 18(1): 25–36.

    Article  CAS  PubMed  Google Scholar 

  36. WANG L, ZHANG F, LI H G, MIAO H, ZHANG J H. Effects of acupuncture on anti-fatigue ability in exercise-induced fatigue rats. Xiandai Zhongyiyao, 2018, 38(3): 99–101.

    CAS  Google Scholar 

  37. FIORENZA M, HOSTRUP M, GUNNARSSON T P, SHIRAI Y, SCHENA F, IAIA F M, BANGSBO J. Neuromuscular fatigue and metabolism during high-intensity intermittent exercise. Med Sci Sports Exerc, 2019, 51(8): 1642–1652.

    Article  PubMed  Google Scholar 

  38. HODY S, ROGISTER B, LEPRINCE P, WANG F, CROISIER J L. Muscle fatigue experienced during maximal eccentric exercise is predictive of the plasma creatine kinase (CK) response. Scand J Med Sci Sports, 2013, 23(4): 501–507.

    Article  CAS  PubMed  Google Scholar 

  39. JIANG P. Effects of Acupuncture at Zusanli on LA, CK and Glu in TRPV1−/− Exercise-induced Fatigue Rats. Shenyang: Master Thesis of Liaoning University of Traditional Chinese Medicine, 2018.

    Google Scholar 

  40. LI C, LUO J, FENG F, YAN B H, FAN H Y, YANG A G, ZHANG H C, HUANG J Y, LAN L, LUO C G. Modern research situation of the acupuncture on “preventive treatment of disease”. Liaoning Zhongyi Zazhi, 2010, 37(1): 153–156.

    Google Scholar 

  41. JIE L H, XIE Y, XU Z H. An analysis of the clinical application pattern of Zusanli (ST36) in Zhen Jiu Da Cheng. Huanqiu Zhongyiyao, 2018, 11(9): 1398–1401.

    Google Scholar 

  42. CHEN Z G, WU L H, DONG M S, LIN J Q. Study of the antifatigue mechanism of point Zusanli acupuncture in high-intensity military training soldiers. Shanghai Zhenjiu Zazhi, 2017, 36(1): 48–50.

    Google Scholar 

  43. BAO C. Effect on ATP Levels and Ultra Microstructure of Quadriceps Femoris in Rats with Exercise-induced Fatigue by Acupuncture Preconditioning. Wuhan: Master Thesis of Hubei University of Chinese Medicine, 2018.

    Google Scholar 

  44. XU F, LI H L, XIA K P, WANG Y Y, BAN W G, XUE Y M. Effect of different acupuncture methods at Zusanli point on exercise-induced fatigue. Zhenjiu Linchuang Zazhi, 2014, 30(9): 55–56.

    Google Scholar 

  45. DONG J Z, WEI Y T, XU H Y, ZHANG Y, YONG R L, XUE Y N, ZHANG L D. Electroacupuncture of “Zusanli” (ST36) raises muscular force by adjusting AMPK/PGC-1α signaling in rats with chronic fatigue syndrome. Zhen Ci Yan Jiu, 2018, 43(6): 335–340.

    PubMed  Google Scholar 

  46. LIANG Y, WANG C X, FANG J Q, SHAO X M, YING X M. Effect of pre-electroacupuncture at “Zusanli” (ST36) on DA and 5-HT contents and their ratio in hypothalamus and striatum in exercise rats. Zhongguo Zhen Jiu, 2011, 31(12): 1101–1105.

    CAS  PubMed  Google Scholar 

  47. LI R B, LIAO J C, SHENG M Q, LIU Z D. Effect of acupuncture at Zusanli and Guanyuan on the relief of military training fatigue in new recruits. Xinan Jun Yi, 2017, 19(4): 312–315.

    Google Scholar 

  48. HU W J. Effects on Metabolomics of Maintaining Cardiac Function by Utilizing Acupuncture Pre-conditioning Therapy on Treating Exercise-induced Fatigue Rats. Wuhan: Master Thesis of Hubei University of Chinese Medicine, 2019.

    Google Scholar 

  49. LIU H P, LIANG B, ZENG C C, HE J Y. Effects of acupuncture at ST36 combination with other point on sport endurance and antioxidant enzyme activity in muscle and liver of exercise induced fatigue rat. Zhongguo Zhongyiyao Xuekan, 2009, 27(7): 1369–1372.

    CAS  Google Scholar 

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Acknowledgments

This work was supported by National Natural Science Foundation of China (国家自然科学基金项目, No. 81273892, No. 81503401, No. 81673732); 2011 Chinese Medicine Industry Research Project (2011年中医药行业科研专项课题, No. 201107006); School Level Project of Preventive Treatment of Diseases in Tianjin University of Traditional Chinese Medicine in 2018 (2018 年天津中医药大学治未病校级课题, No. XJ201801).

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Authors and Affiliations

  1. Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China

    Xinrui Niu  (牛芯蕊), Xiaoling Wang  (王晓玲), Tao Wang  (汪涛) & Liping Shi  (史丽萍)

  2. Henan Medical Technician College, Kaifeng, 475000, China

    Kun Yang  (杨琨)

  3. Wuhan Sports University, Wuhan, 430079, China

    Yongjie Li  (李永杰)

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  1. Xinrui Niu  (牛芯蕊)
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  4. Xiaoling Wang  (王晓玲)
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Corresponding authors

Correspondence to Tao Wang  (汪涛) or Liping Shi  (史丽萍).

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Conflict of Interest

The authors declare that there is no potential conflict of interest in this article.

Co-first Authors: NIU Xinrui, master degree candidate; YANG Kun, lecturer

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Niu, X., Yang, K., Li, Y. et al. Meta-analysis of acupuncture intervening exercise-induced fatigue. J. Acupunct. Tuina. Sci. 20, 236–246 (2022). https://doi.org/10.1007/s11726-022-1318-4

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