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Clinical study of warm needling moxibustion plus intra-articular injection of sodium hyaluronate for hip involvement in ankylosing spondylitis

温针灸联合关节腔内注射玻璃酸钠治疗强直性脊柱炎髋关节病变的临床研究

  • Clinical Study
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Abstract

Objective

To observe the efficacy of warm needling moxibustion plus intra-articular injection of sodium hyaluronate for hip involvement in ankylosing spondylitis (AS).

Methods

A total of 60 patients with hip involvement in AS were randomly divided into a control group and an observation group, with 30 cases in each group. The patients in the control group were given an intra-articular injection of sodium hyaluronate, once a week. The patients in the observation group were given additional warm needling moxibustion, once a day, with a 2-day interval after five consecutive days of treatment. After 5 weeks, changes in such indicators as visual analog scale (VAS) score, Harris score, Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI), serum cartilage oligomeric matrix protein (COMP), interleukin (IL)-17 were observed, and the efficacy was evaluated. Six months after treatment, Bath ankylosing spondylitis radiology index-hip (BASRI-hip) was evaluated.

Results

After treatment, the total effective rate in the observation group was higher than that in the control group (P<0.05). After treatment, the VAS scores in both groups were lower than those before treatment (P<0.05), and the score of the observation group was lower than that of the control group (P<0.05). After treatment, the Harris scores of both groups were higher than those before treatment (P<0.05), and the score of the observation group was higher than that of the control group (P<0.05). Six months after treatment, the BASRI-hip score of the control group was higher than that before treatment (P<0.05), while the score of the observation group was not significantly different from that before treatment (P>0.05) and was lower than that of the control group (P<0.05). After treatment, the scores of BASDAI and BASFI of both groups were lower than those before treatment (P<0.05), and the scores of the observation group were lower than those of the control group (P<0.05). After treatment, the levels of serum COMP and IL-17 of both groups were lower than those before treatment (P<0.05), and the levels of the observation group were lower than those of the control group (P<0.05).

Conclusion

The efficacy of warm needling moxibustion plus intra-articular injection of sodium hyaluronate for hip involvement in AS is better than the intra-articular injection of sodium hyaluronate alone. This combined approach can alleviate hip pain, improve hip functions, delay the destruction of the hip, prevent AS development, and reduce the levels of serum COMP and IL-17.

摘要

目的

观察温针灸联合关节腔内注射玻璃酸钠治疗强直性脊柱炎(AS)髋关节病变的疗效。

方法

将60例AS髋关节病变患者根据随机数字表法分为对照组和观察组, 每组30例。对照组予关节腔内注射玻璃酸钠治疗, 每周1次;观察组在此基础上加用温针灸治疗, 每日1次, 治疗5 d后休息2 d。治疗5周后观察视觉模拟量表(VAS)评分、Harris评分、巴氏AS疾病活动指数(BASDAI)、巴氏AS功能指数(BASFI)、血清软骨寡聚基质蛋白(COMP)及白介素(IL)-17水平的变化, 并评价疗效。治疗结束后6个月评价巴氏AS髋关节放射学指数(BASRI-hip)。

结果

治疗后, 观察组总有效率高于对照组(P<0.05)。治疗后两组VAS评分均较治疗前降低(P<0.05), 观察组评分低于对照组(P<0.05)。治疗后两组Harris评分均较治疗前升高(P<0.05), 观察组高于对照组(P<0.05)。对照组治疗结束后6个月的BASRI-hip评分高于治疗前(P<0.05),观察组评分与治疗前无统计学差异(P>0.05), 且低于对照组(P<0.05)。两组治疗后BASDAI及BASFI评分均较治疗前降低(P<0.05), 观察组低于对照组(P<0.05)。两组治疗后血清COMP、IL-17水平均较治疗前降低(P<0.05), 观察组低于对照组(P<0.05)。

结论

温针灸联合关节腔内注射玻璃酸钠治疗AS髋关节病变的疗效优于单独关节腔内注射玻璃酸钠, 可缓解患髋疼痛, 改善髋关节功能, 延缓髋关节结构破坏进程, 改善躯体功能, 阻止AS病情发展, 降低血清COMP和IL-17水平。

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Authors and Affiliations

  1. Shanghai East Hospital Affiliated to Tongji University, Shanghai, 200120, China

    Lei Ye  (叶磊) & Yichao Zou  (邹一超)

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  1. Lei Ye  (叶磊)
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  2. Yichao Zou  (邹一超)
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Correspondence to Lei Ye  (叶磊).

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Ye, L., Zou, Y. Clinical study of warm needling moxibustion plus intra-articular injection of sodium hyaluronate for hip involvement in ankylosing spondylitis. J. Acupunct. Tuina. Sci. 20, 206–212 (2022). https://doi.org/10.1007/s11726-022-1314-8

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