Skip to main content
Log in

Assessment of the safety and efficacy of acupuncture in erectile dysfunction treatment

针刺治疗勃起功能障碍安全性及疗效的评价

  • Systematic Review
  • Published:
Journal of Acupuncture and Tuina Science Aims and scope Submit manuscript

Abstract

Objective

To assess the safety and efficacy of acupuncture in erectile dysfunction treatment.

Methods

A systematic literature search was conducted to identify relevant studies. Seven electronic databases including Popline, World Health Organization (WHO) Global Health Library (GHL), System for Information on Grey Literature in Europe (SIGLE), Scopus, Institute for Scientific Information (ISI) Web of Science, PubMed and Virtual Health Library (VHL) were utilized to carry out the search. A manual search was further conducted for relevant publications from references of the included articles, relevant papers in PubMed and Google Scholar, and primary studies that had cited the included papers. Hand-search using each keyword to avoid missing any relevant publications was also carried out.

Results

The literature search yielded 2 818 reports after removing duplicates using Endnote software. There were 21 studies eligible for full-text screening and five of which were subsequently included. After two studies identified from the manual search were added, a total of seven studies were found suitable to carry out the systematic review and meta-analysis. Five of them were used for quantitative and qualitative analysis, while two were only used for qualitative analysis. There were four clinical trials, one pilot study, one case report, and one animal study.

Conclusion

Acupuncture can improve male erectile function.

【摘要】

目的: 评价针刺治疗勃起功能障碍的安全性及疗效。 方法: 采用文献检索法对相关研究进行系统检索。利用Popline、世界卫生组织(WHO)全球卫生图书馆(GHL)、欧洲灰色文献信息系统(SIGLE)、Scopus、美国科学信息研究所(ISI) Web of Science、PubMed和VHL 7个电子数据库进行检索。通过从收录文章的参考文献、PubMed和谷歌学术的相关论文以及引用收录论文的初步研究中搜索相关刊物, 并进行进一步人工搜索。此外, 对每个关键词都进行手动检索以避免遗漏相关文献。 结果: 用Endnote软件剔除重复文献后, 共得到2 818篇文献。有21项研究符合全文筛选的条件, 其中5项随后被纳入。加上从手动检索中确定的2项研究后, 共有7项研究适合进行系统性回顾和meta分析。其中5项用于定量和定性分析, 2项仅用于定性分析。共有4项临床试验、1项初步研究、1份病例报告和1项动物研究。结论: 针刺治疗能够改善男性勃起功能。

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J Urol, 1994, 151(1): 54–61.

    Article  CAS  PubMed  Google Scholar 

  2. Khera M, Goldstein I. Erectile dysfunction. BMJ Clin Evid, 2011, 2011: 1803.

    PubMed  PubMed Central  Google Scholar 

  3. Hatzimouratidis K, Amar E, Eardley I, Giuliano F, Hatzichristou D, Montorsi F, Vardi Y, Wespes E; European Association of Urology. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. Eur Urol, 2010, 57(5): 804–814.

    Article  PubMed  Google Scholar 

  4. Muneer A, Kalsi J, Nazareth I, Arya M. Erectile dysfunction. BMJ, 2014, 348: g129.

    Article  PubMed  Google Scholar 

  5. Aung HH, Dey L, Rand V, Yuan CS. Alternative therapies for male and female sexual dysfunction. Am J Chin Med, 2004, 32(2): 161–173.

    Article  PubMed  Google Scholar 

  6. Ernst E, Pittler MH, Stevinson C, White A. The Desktop Guide to Complementary and Alternative Medicine: An Evidence-based Approach. Edinburgh: Mosby Elsevier, 2001.

    Google Scholar 

  7. Cheng KJ. Neuroanatomical basis of acupuncture treatment for some common illnesses. Acupunct Med, 2009, 27(2): 61–64.

    Article  PubMed  Google Scholar 

  8. Napadow V, Ahn A, Longhurst J, Lao L, Stener-Victorin E, Harris R, Langevin HM. The status and future of acupuncture mechanism research. J Altern Complement Med, 2008, 14(7): 861–869.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Quality assessment tool for observational cohort and cross-sectional studies. (2017-12-11) [2019-05-17]. http://bjsm.bmj.com/content/bjsports/early/2018/03/07/bjsports-2016-096274/DC2/embed/inline-supplementarymaterial-2.pdf?download=true.

  10. Leung A, Heal C, Perera M, Pretorius C. A systematic review of patient-related risk factors for catheter-related thrombosis. J Thromb Thrombolysis, 2015, 40(3): 363–373.

    Article  CAS  PubMed  Google Scholar 

  11. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011.

  12. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 1959, 22(4): 719–748.

    CAS  PubMed  Google Scholar 

  13. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials, 1986, 7(3): 177–188.

    Article  CAS  PubMed  Google Scholar 

  14. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ, 2003, 327(7414): 557–560.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088–1101.

    Article  CAS  PubMed  Google Scholar 

  16. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629–634.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L. Comparison of two methods to detect publication bias in meta-analysis. JAMA, 2006, 295(6): 676–680.

    Article  CAS  PubMed  Google Scholar 

  18. Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics, 2000, 56(2): 455–463.

    Article  CAS  PubMed  Google Scholar 

  19. Mengoli C, Cruciani M, Barnes RA, Loeffler J, Donnelly JP. Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis. Lancet Infect Dis, 2009, 9(2): 89–96.

    Article  CAS  PubMed  Google Scholar 

  20. Thompson SG, Higgins JP. How should meta-regression analyses be undertaken and interpreted?. Stat Med, 2002, 21(11): 1559–1573.

    Article  PubMed  Google Scholar 

  21. Aydin S, Ercan M, Caşkurlu T, Taşçi AI, Karaman I, Odabas, O, Yilmaz Y, Ağargün MY, Kara H, Sevin G. Acupuncture and hypnotic suggestions in the treatment of non-organic male sexual dysfunction. Scand J Urol Nephrol, 1997, 31(3): 271–274.

    Article  CAS  PubMed  Google Scholar 

  22. Kho HG, Sweep CG, Chen X, Rabsztyn PR, Meuleman EJ. The use of acupuncture in the treatment of erectile dysfunction. Int J Impot Res, 1999, 11(1): 41–46.

    Article  CAS  PubMed  Google Scholar 

  23. Engelhardt PF, Daha LK, Zils T, Simak R, König K, Pflüger H. Acupuncture in the treatment of psychogenic erectile dysfunction: first results of a prospective randomized placebo-controlled study. Int J Impot Res, 2003, 15(5): 343–346.

    Article  CAS  PubMed  Google Scholar 

  24. Khamba B, Aucoin M, Lytle M, Vermani M, Maldonado A, Iorio C, Cameron C, Tsirgielis D, D’Ambrosio C, Anand L, Katzman MA. Efficacy of acupuncture treatment of sexual dysfunction secondary to antidepressants. J Altern Complement Med, 2013, 19(11): 862–869.

    Article  PubMed  Google Scholar 

  25. Hiroshi T. Acupuncture in the treatment of erectile dysfunction among a diabetic population of sildenafil citrate non-responder. JAM, 2014, 10(1): 14–17.

    Google Scholar 

  26. Liu P, Liu SJ, Xu SW, Yang Y, Shou Y, Zhang KY, Jiang HR, Zhang BM. Clinical observation on warm needling moxibustion for erectile dysfunction. J Acupunct Tuina Sci, 2017, 15(1): 59–62.

    Article  Google Scholar 

  27. Huang AC, Yeh KY, Cheng YY, Dubey NK, Chiu AW, Tsai TH. Investigation of interactive activity of electro-acupuncture on pharmacokinetics of sildenafil and their synergistic effect on penile blood flow in rats. Int J Mol Sci, 2018, 19(8): 2153.

    Article  PubMed Central  Google Scholar 

  28. Cui XM, Zhou J, Qin ZS, Liu ZS. Acupuncture for erectile dysfunction: a systematic review. Biomed Res Int, 2016, 2016: 2171923.

    PubMed  PubMed Central  Google Scholar 

  29. Jiang RM, Qu Y, Wang T, Wan YL, Xu WB. Meta-analysis of clinical effectiveness of the acupuncture treatment for erectile dysfunction. Zhongguo Xingkexue, 2018, 27(2): 82–85.

    Google Scholar 

  30. Lai BY, Cao HJ, Yang GY, Jia LY, Grant S, Fei YT, Wong E, Li XL, Yang XY, Liu JP. Acupuncture for treatment of erectile dysfunction: a systematic review and meta-analysis. World J Mens Health, 2019, 37(3): 322–338.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

I would like to express my appreciation to Prof. Dr. Charles Savona-Ventura for his keen interest in the progress o f this work. He has been very generous in providing me with knowledge and scientific materials. Sincere thanks to Dr. Samer Saad Ali Adwal for his support throughout the y ear. Special thanks to all the Chinese doctors involved in the course for the supervision and help at all stages of this study.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Munirah Mansour Alamro.

Additional information

Author: Munirah Mansour Alamro, M.M.

Conflict of Interest

There is no potential conflict of interest in this article.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Alamro, M.M. Assessment of the safety and efficacy of acupuncture in erectile dysfunction treatment. J. Acupunct. Tuina. Sci. 19, 167–173 (2021). https://doi.org/10.1007/s11726-021-1250-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11726-021-1250-z

Keywords

【关键词】

【中图分类号】

【文献标志码】

Navigation