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Research advances in the brain mechanisms of acupuncture effects based on the BOLD-fMRI technology

基于BOLD-fMRI 技术的针刺效应的脑机制研究进展

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Abstract

By summarizing the recent literatures on brain mechanisms with acupuncture intervention based on blood oxygenation level-dependent (BOLD)-functional magnetic resonance imaging (fMRI), the BOLD-fMRI examination and analysis methods, the points to be acupunctured, the corresponding meridian activation regions, the specific intensity range, functions and indications of the acupoints, the manifestation of ‘bi-directional regulation’ characteristics, fMRI performance of chronergy, laterality and needling qi of acupuncture were reviewed to provide the ideas for future research in this area.

摘要

通过总结近年来针刺干预血氧水平依赖的功能性磁共振成像(BOLD-fMRI)脑机制研究的相关文献, 对 BOLD-fMRI检查及分析方法、施针穴位及对应经脉激活区域、针刺的穴位特异性的强度范围及功能主治、 “双向调节”特性的体现、针刺效应的时效性、偏侧性及得气的fMRI表现进行综述, 并提出该领域以后的研究思路。

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Acknowledgments

This work was supported by National Natural Science Foundation of China (国家自然科学基金项目, No. 81860879, No. 81660816, No. 81260560); Medical and Health Research of Lanzhou Health Science and Technology Development Project (兰州市卫生健康科技发 展项目医药卫生科研课题, No. 2019-052); Lanzhou Talent Innovation and Entrepreneurship Projects (兰州市人 才创新创业项目, No. 2019-RC-39).

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Authors and Affiliations

  1. School of Acupuncture and Tuina, Gansu University of Traditional Chinese Medicine, Lanzhou, 730000, China

    Yan Sun  (孙燕), Chong-bing Ma  (马重兵), An-guo Liu  (刘安国), Xing-ke Yan  (严兴科) & Jing Jia  (贾静)

  2. Lanzhou Bright Eye Hospital, Gansu Province, Lanzhou, 730000, China

    Yan Sun  (孙燕)

  3. Gansu Rehabilitation Center Hospital, Lanzhou, 730000, China

    Yan Sun  (孙燕)

  4. School of Clinical Medicine, Hangzhou Normal University, Hangzhou, 311121, China

    Wen Zheng  (郑雯)

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  1. Yan Sun  (孙燕)
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  2. Chong-bing Ma  (马重兵)
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  3. An-guo Liu  (刘安国)
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  4. Xing-ke Yan  (严兴科)
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  6. Wen Zheng  (郑雯)
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Correspondence to Xing-ke Yan  (严兴科).

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Sun, Y., Ma, Cb., Liu, Ag. et al. Research advances in the brain mechanisms of acupuncture effects based on the BOLD-fMRI technology. J. Acupunct. Tuina. Sci. 18, 474–480 (2020). https://doi.org/10.1007/s11726-020-1217-5

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  • DOI: https://doi.org/10.1007/s11726-020-1217-5

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