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Effects of intradermal needle therapy plus pinaverium bromide on gastrointestinal hormone levels in irritable bowel syndrome-diarrhea patients

皮内针加匹维溴铵对腹泻型肠易激综合征患者胃肠激素水平的影响

  • Clinical Study
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Journal of Acupuncture and Tuina Science Aims and scope Submit manuscript

Abstract

Objective

To observe the clinical efficacy difference in treating irritable bowel syndrome-diarrhea (IBS-D) of liver-qi stagnation and spleen-deficiency pattern with different treatment protocols, and the effects on serum levels of 5-hydroxytryptamine (5-HT), substance P (SP) and vasoactive intestinal peptide (VIP), for unveiling the mechanism of intradermal needle therapy plus pinaverium bromide in treating IBS-D.

Methods

A total of 123 IBS-D patients were divided into an observation group, a Western medication group and an integrated Western and Chinese medication group using the random number table method, with 41 cases in each group. The Western medication group was given oral pinaverium bromide, 50 mg each time and 3 times a day. The integrated Western and Chinese medication group was given additional Chinese herbal medicine Tong Xie Yao Fang, one dose each day. The observation group was given additional intradermal needle therapy on the basis of the Western medication group. The whole intervention lasted for 6 weeks. Before and after treatment, the scores of gastrointestinal symptoms, traditional Chinese medicine (TCM) symptoms, irritable bowel syndrome (IBS) symptom severity scale (IBS-SSS) and IBS quality of life (IBS-QOL) questionnaire, as well as the serum levels of 5-HT, SP and VIP were observed. The clinical efficacy was estimated.

Results

The total effective rate was 92.7% in the observation group, 68.3% in the Western medication group and 78.1% in the integrated Western and Chinese medication group. The total effective rate was higher in the observation group than in the other two groups, and higher in the integrated Western and Chinese medication group than in the Western medication group, showing statistical significance (all P<0.05). After treatment, the scores of gastrointestinal symptoms, TCM symptoms and IBS-SSS showed significant decreases in the three groups, presenting statistical significance compared with the baseline (all P<0.05); the scores of gastrointestinal symptoms, TCM symptoms and IBS-SSS were notably lower in the observation group than in the other two groups (all P<0.05), and lower in the integrated Western and Chinese medication group than in the Western medication group (all P<0.05). After treatment, the eight component scores of IBS-QOL showed significant increases in the three groups compared with the baseline (all P<0.05); the eight component scores in IBS-QOL were significantly higher in the observation group than in the other two groups (all P<0.05), and higher in the integrated Western and Chinese medication group than in the Western medication group (all P<0.05). After treatment, the serum levels of 5-HT, SP and VIP decreased markedly in the three groups compared with the baseline (all P<0.05); the serum levels of 5-HT, SP and VIP were significantly lower in the observation group than in the other two groups (all P<0.05), and lower in the integrated Western and Chinese medication group than in the Western medication group (P<0.05).

Conclusion

Treatment with intradermal needle therapy plus pinaverium bromide results in significant improvements in the gastrointestinal symptoms and quality of life in patients with IBS-D of liver-qi stagnation and spleen deficiency pattern, and effectively regulates the gastrointestinal hormone production.

摘要

目的:观察不同治疗方案治疗肝郁脾虚腹泻型肠易激综合征(IBS-D)的临床疗效差异及对血清5-羟色胺 (5-HT)、P物质(SP)和血管活性肠肽(VIP)水平的影响, 揭示皮内针疗法联合匹维溴铵治疗IBS-D的作用机理。方法: 将123例IBS-D患者按随机数字表法分为观察组、西药组和西药加中药组, 每组41例。西药组口服匹维溴铵片, 每 次50 mg, 每日3次。西药加中药组在西药组的基础上口服痛泻要方中草药, 每日1剂。观察组在西药组治疗基础 上加用皮内针疗法。疗程为6周。观察治疗前后胃肠道症状、中医证候、IBS严重程度、IBS-QOL 量表评分及血清 5-HT、SP和VIP水平, 并评价临床疗效。结果:观察组总有效率为92.7%, 西药组为68.3%, 西药加中药组为78.1%, 观 察组总有效率高于其他2组, 西药加中药组总有效率高于西药组, 组间差异均有统计学意义(均P<0.05)。治疗后, 3组胃肠道症状、中医证候、IBS严重程度评分均明显下降, 与本组治疗前均有统计学差异(均P<0.05); 观察组胃 肠道症状、中医证候、IBS严重程度评分明显低于其他2组(均P<0.05), 西药加中药组上述3项评分均低于西药组(均 P<0.05)。治疗后, 3组患者的IBS-QOL 量表的8项评分均较本组治疗前明显升高(均P<0.05); 观察组IBS-QOL量表 8项评分均明显高于其他2组(均P<0.05); 西药加中药组IBS-QOL量表8项评分均高于西药组(均P<0.05)。治疗后, 3组患者血清5-HT、SP和VIP水平均较本组治疗前明显降低(均P<0.05); 观察组血清5-HT、SP和VIP水平面明显低于 其余2组(均P<0.05), 西药加中药组血清5-HT、SP和VIP水平均低于西药组(P<0.05)。结论:皮内针疗法联合匹维 溴铵明显地改善腹泻型肠易激综合征肝郁脾虚证患者的胃肠道症状及生活质量, 可有效调节机体胃肠激素分泌。

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References

  1. Feng WL, Ren HT, Hong MK, Chen SC. Current status of the epidemiological investigation of irritable bowel syndrome in China. Zhejiang Zhongyiyao Daxue Xuebao, 2017, 41(8): 685–688.

    Google Scholar 

  2. Yu W, Jin Y. Progress in the research of using integrated Chinese and Western medicine to treat irritable bowel syndrome-diarrhea. Xiandai Zhongyiyao, 2017, 37(2): 89–92.

    Google Scholar 

  3. Wang YX, Wang LJ. Sixty cases of irritable bowel syndrome treated with herb-partitioned moxibustion. Zhongyi Yanjiu, 2018, 31(9): 49–53.

    Google Scholar 

  4. Drossman DA, Dumitrascu DL. Rome III: new standard for functional gastrointestinal disorders. J Gastrointestin Liver Dis, 2006, 15(3): 237–241.

    PubMed  Google Scholar 

  5. Ministry of Health of the People’s Republic of China. Guiding Principles for Clinical Study of New Chinese Medicines. Beijing: China Medical Science Press, 2002: 139–143.

    Google Scholar 

  6. Adam B, Liebregts T, Saadat-Gilani K, Vinson B, Holtmann G. Validation of the gastrointestinal symptom score for the assessment of symptoms in patients with functional dyspepsia. Aliment Pharmacol Ther, 2005, 22(4): 357–363.

    Article  CAS  Google Scholar 

  7. Francis CY, Morris J, Whorwell PJ. The irritable bowel severity scoring system; a simple method of monitoring irritable bowel syndrome and its progress. Aliment Pharmacol Ther, 1997, 11(2): 395–402.

    Article  CAS  Google Scholar 

  8. Design of Treatment Trials Committee, Irvine EJ, Whitehead WE, Chey WD, Matsueda K, Shaw M, Talley NJ, Veldhuyzen van Zanten SJ. Design of treatment trials for functional gastrointestinal disorders. Gastroenterology, 2006, 130(5): 1538–1551.

    Article  Google Scholar 

  9. Lin YL, Ruan WQ, Lin YZ, Guan JX, Li QY. Analysis of psychosocial status, intestinal barrier function and visceral sensitivity in patients with diarrhea-predominant irritable bowel syndrome. Xiandai Xiaohua Ji Jieru Zhiliao, 2018, 23(3): 289–292.

    Google Scholar 

  10. Chen JP, Chen K. Clinical observation of Xiaoyao powder combined with pinaverium bromide tablets on the treatment of diarrhea predominant irritable bowel syndrome. Hebei Zhongyi, 2016, 38(2): 239–242.

    CAS  Google Scholar 

  11. Zhuo BF, Zhang YQ, Ning XY. Effect of Tongxie Yao Fang combined with Sijunzi decoction on brain-gut peptide in irritable bowel syndrome patients with diarrhea type. Nanjing Zhongyiyao Daxue Xuebao, 2019, 35(1): 25–28.

    Google Scholar 

  12. Qin EQ, Lu LY, Tian Z, Li Y. Rule analysis of points selection for acupuncture treatment of peri-menopausal insomina. Sichuan Zhongyi, 2015, 33(5): 185–188.

    Google Scholar 

  13. Chen YY, Liao L, Yang C, Chang XR, Zhang W. Analysis of “five main and collateral channels compatibility” in treating chronic diarrhea. Zhongyiyao Daobao, 2018, 24(17): 131–133.

    Google Scholar 

  14. Su ZW, Fu L, Zheng HB, Li Y. Analysis of the bidirectional regulation effect of ancient acupuncture on intestinal motility based on data mining. Zhonghua Zhongyiyao Zazhi, 2015, 30(6): 2202–2206.

    Google Scholar 

  15. Jin YQ, Zhan DW, Luo KT, Shi XW. Randomized controlled study on acupuncture plus acupoint application for irritable bowel syndrome with diarrhea. Shanghai Zhenjiu Zazhi, 2017, 36(6): 684–687.

    Google Scholar 

  16. Shi JJ, Pan XH, Xu JS. Clinical application of five meridian points of Stomach Meridian. Zhongguo Zhongyiyao Xiandai Yuancheng Jiaoyu, 2019, 17(5): 124–128.

    Google Scholar 

  17. Fang ZZ, Zheng HD, Huang Y, Ji J, Ding BY, Liu HR, Ma XP, Wu LY, Zhou ZG, Wu HG, Li J. Application rules of meridians and acupoints used in the treatment of gastrointestinal diseases associated abdominal pain in ancient literature. Shijie Kexue Jishu: Zhongyiyao Xiandaihua, 2018, 25(5): 762–768.

    Google Scholar 

  18. Tian JQ, Zhang WY. Therapeutic observation of acupuncture at Xingjian (LR 2) for 78 cases of acute stomachache. Shijie Zuixin Yixue Xinxi Wenzhai, 2015, 15(27): 135.

    Google Scholar 

  19. Xu ZS, Yang SL, Lu XL, Chen L, Chen HX. Theory of press-needle and superficial acupuncture and general situation of treatment of spleen and stomach diseases. Shiyong Zhongyi Neike Zazhi, 2019, 32(2): 75–77.

    Google Scholar 

  20. Wang TJ, Wang LL. Clinical features and indications of needle-embedding therapy. Shanghai Zhenjiu Zazhi, 2007, 26(10): 37–38.

    Google Scholar 

Download references

Acknowledgments

This work was sponsored by 2016 Medical Alliance Clinical Research Project of Dongzhimen Hospital, Beijing University of Chinese Medicine (2016 年度北京中医药大 学东直门医院医疗联盟临床研究专项资助项目, No. 2016YLLM01).

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Authors and Affiliations

  1. Tangshan Hospital of Traditional Chinese Medicine, Hebei Province, Tangshan, 063000, China

    Xiao-lei Zhang  (张晓蕾), Hai-yan Gu  (谷海燕) & Zhi-min Shi  (石志敏)

  2. Traditional Chinese Medical College, North China University of Science and Technology, Tangshan, 063000, China

    Xue-qing Li  (李雪青)

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  1. Xiao-lei Zhang  (张晓蕾)
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  2. Hai-yan Gu  (谷海燕)
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Correspondence to Zhi-min Shi  (石志敏).

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Informed consent was obtained from all individual participants in this study.

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Zhang, Xl., Gu, Hy., Shi, Zm. et al. Effects of intradermal needle therapy plus pinaverium bromide on gastrointestinal hormone levels in irritable bowel syndrome-diarrhea patients. J. Acupunct. Tuina. Sci. 18, 431–437 (2020). https://doi.org/10.1007/s11726-020-1211-y

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