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Therapeutic efficacy and mechanism of heat-sensitive moxibustion for adjuvant treatment of depression in Parkinson disease

热敏灸辅助治疗帕金森病抑郁的临床疗效及作用机制探讨

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Abstract

Objective

To observe the clinical efficacy of heat-sensitive moxibustion for adjuvant treatment of depression in Parkinson disease and explore its mechanism.

Methods

A total of 80 patients with Parkinson disease coupled with depression were randomized into an observation group and a control group, with 40 cases in each group. The control group was treated with levodopa and benserazide hydrochloride tablets and paroxetine tablets, while the observation group was treated with heat-sensitive moxibustion on the basis of the medications in the control group. The treatment course was 2 months. The Hamilton depression scale-17 (HAMD-17), unified Parkinson’s disease rating scale (UPDRS) and Parkinson’s disease quality of life questionnaire-39 (PDQ-39) were scored before and after the treatment, and the efficacy was evaluated after treatment. Levels of patients’ serum dopamine (DA), 5-hydroxytryptamine (5-HT), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were detected before and after the treatment.

Results

After treatment, the total effective rate of the observation group was higher than that of the control group (P<0.05). The HAMD-17 scores in the two groups decreased significantly after treatment (both P<0.05), and the score in the observation group was obviously lower than that in the control group (P<0.05). The component scores and total scores of UPDRS in both groups decreased significantly (all P<0.05), and the scores in the observation group were lower than those in the control group (all P<0.05). The score of PDQ-39 in the observation group decreased significantly (P<0.05), and was lower than that in the control group (P<0.05). After treatment, the serum DA and 5-HT levels in the observation group increased significantly (both P<0.05) and the TNF-α and IL-6 levels decreased significantly (both P<0.05), which were statistically different from those in the control group (all P<0.05).

Conclusion

Heat-sensitive moxibustion has certain auxiliary effect in treating depression in Parkinson disease, significantly improving clinical symptoms and the quality of life, which may be related to the up-regulation of DA and 5-HT levels and down-regulation of TNF-α and IL-6 levels.

摘要

目的

观察热敏灸辅助治疗帕金森病抑郁的临床疗效并探讨其作用机制.

方法

将80例帕金森病抑郁患者随机分为观察组和对照组, 每组40例. 对照组口服多巴丝肼和帕罗西汀治疗; 观察组在对照组药物治疗基础上加用热敏灸治疗, 疗程为2个月. 治疗前后进行汉密尔顿抑郁量表-17(HAMD-17), 统一帕金森病评定量表(UPDRS)及帕金森病生存质量问卷-39(PDQ-39)评分; 于治疗后进行疗效评价; 并于治疗前后测定患者血清多巴胺(DA), 5-羟色胺(5-HT)及肿瘤坏死因子-α (TNF-α)和白介素-6 (IL-6)水平.

结果

治疗后, 观察组的总有效率高于对照组(P<0.05); 两组HAMD-17评分均较治疗前明显降低(均P<0.05), 且观察组HAMD-17评分明显低于对照组(P<0.05). 两组UPDRS各分项评分及总分均明显减少(均P<0.05), 且观察组各分项评分及总分均低于对照组(均P<0.05). 观察组患者的PDQ-39评分明显降低(P<0.05), 且低于对照组(P<0.05). 治疗后, 观察组患者血清DA和5-HT水平明显提高(均P<0.05), TNF-α和IL-6水平明显降低(均P<0.05), 且均与对照组有统计学差异(均P<0.05).

结论

热敏灸辅助治疗帕金森病抑郁疗效确切, 能显著改善患者临床症状, 提高患者生活质量, 可能与其上调DA和5-HT水平, 降低TNF-α和IL-6水平相关.

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Authors and Affiliations

  1. Lishui Second People’s Hospital, Zhejiang, 323000, China

    Xiao-mei Wang  (王笑媚) & Chun-jiao Rong  (荣春娇)

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  1. Xiao-mei Wang  (王笑媚)
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  2. Chun-jiao Rong  (荣春娇)
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Correspondence to Xiao-mei Wang  (王笑媚).

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Wang, Xm., Rong, Cj. Therapeutic efficacy and mechanism of heat-sensitive moxibustion for adjuvant treatment of depression in Parkinson disease. J. Acupunct. Tuina. Sci. 18, 33–39 (2020). https://doi.org/10.1007/s11726-020-1154-3

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  • DOI: https://doi.org/10.1007/s11726-020-1154-3

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