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Memory response to manual acupuncture in chronic insomniacs: evidence from event-related potentials

基于事件相关电位研究手捻针针刺对慢性失眠患者记忆功能的影响

  • Clinical Study
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Abstract

Objective

To investigate the effectiveness and safety of manual acupuncture for memory loss and sleep quality in chronic insomniacs.

Methods

A total of 60 eligible participants were enrolled and randomized into either a treatment group or a control group, with 30 cases in each group. The treatment group was intervened by manual acupuncture whereas the control group was given sham acupuncture. In the two groups, the interventions were offered once every other day and three times a week, for 8 weeks in total. Before and after the treatment, Pittsburgh sleep quality index (PSQI) and eventrelated potentials (ERPs) were used to assess the patients’ sleep quality and memory, respectively. Meanwhile, adverse events were monitored and recorded.

Results

After 8-week treatment, both the treatment group and the control group showed a significant decrease in the PSQI global score (P<0.001, P<0.01), and the decrease in the treatment group was more significant than that in the control group (P<0.001). The intra-group comparisons of ERPs indicated that, the latencies of N1 and P3 were shortened and the amplitudes of N1 and P3 were increased in the treatment group after the intervention, and the differences were statistically significant (P<0.05, P<0.001); in the control group, there were no significant changes in the latency and amplitude after the treatment (P>0.05). The between-group comparisons of ERPs showed that the treatment group was more effective than the control group in shortening the latency of P3 (P<0.01).

Conclusion

Acupuncture can be a safe and effective treatment option for chronic insomnia coupled with memory impairment.

摘要

目的

观察手捻针针刺改善慢性失眠患者记忆减退及睡眠质量的有效性及安全性。

方法

将符合入组标准的60例受试者随机分为治疗组和对照组, 每组30例。治疗组给予手捻针针刺治疗, 对照组给予假针刺干预。两组受试者每周均隔日治疗1次, 每周3次, 共治疗8周。治疗前后采用匹兹堡睡眠质量指数PSQI量表及事件相关电位 (ERPs)分别观察患者的睡眠质量及记忆情况, 以此客观评价手捻针针刺的临床疗效。同时观察并记录不良反应事 件。

结果

治疗8周后, 治疗组与对照组PSQI评分均有明显下降, 治疗前后评分差异均有统计学意义(P<0.001,P<0.01), 且治疗组PSQI评分下降更显著(P<0.001)。ERPs组内比较显示, 治疗组N1、P3峰潜伏期治疗后缩短, N1、P3峰波幅增加, 差异均有统计学意义(P<0.05, P<0.001); 对照组治疗前后各峰潜伏期及波幅变化均不显著(P> 0.05)。ERPs组间比较显示, 治疗组缩短P3峰潜伏期的效果较对照组更显著(P<0.01)。

结论

对于慢性失眠及其伴随的记忆损害, 手捻针针刺可作为一种安全有效的治疗方法。

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Acknowledgments

This work was supported by Scientific Project of National Science & Technology Pillar Program During the Eleventh Five-year Plan Period (国家“十一五”科技支撑 计划项目, No. 2007BAI10B01-027); Shanghai Municipal Commission of Health and Family Planning, Scientific and Technological Innovation Project of TCM: Mobile Internet-based Insomnia Rehabilitation Prevention (Chronic Disease Management) Guidance Platform [上海 市卫生和计划生育委员会中医药科技创新项目——基 于移动互联网的失眠症“治未病”康复预防(慢病管理)指 导平台, No. ZYKC20161016].

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Authors and Affiliations

  1. Shanghai Municipal Hospital of TCM Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China

    Fei-yi Zhao  (赵非一), Yu-Fang Hong  (洪钰芳) & Hong Xu  (许红)

  2. Haiyan People’s Hospital, Haiyan, Zhejiang, 314300, China

    Zhe-yuan Zhang  (张浙元)

  3. Department of Education, East China Normal University, Shanghai, 200062, China

    Xiao-jie Xia  (夏小芥)

  4. School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China

    Ying-xia Zhao  (赵英侠) & Hai-xia Yan  (燕海霞)

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  1. Fei-yi Zhao  (赵非一)
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Correspondence to Hong Xu  (许红).

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Zhao, Fy., Zhang, Zy., Xia, Xj. et al. Memory response to manual acupuncture in chronic insomniacs: evidence from event-related potentials. J. Acupunct. Tuina. Sci. 16, 382–388 (2018). https://doi.org/10.1007/s11726-018-1078-3

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  • DOI: https://doi.org/10.1007/s11726-018-1078-3

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