Skip to main content
SpringerLink
Log in

Electroacupuncture plus external application of Chinese medicine for knee osteoarthritis

电针联合中药外敷治疗膝骨性关节炎

  • Clinical Study
  • Published:
Journal of Acupuncture and Tuina Science Aims and scope Submit manuscript

Abstract

Objective

To reveal the action mechanism and efficacy of electroacupuncture (EA) plus external application of Wei Ling Xian (Radix Clematidis) extract in treating knee osteoarthritis (KOA), for providing theoretical evidence and novel plan for the treatment of KOA.

Methods

Totally 284 inpatients were divided into an EA group and an observation group by the random number table, 142 cases in each group. The EA group was intervened by EA, ultrashort waves, and oral administration of Glucosamine Hydrochloride capsules; while the observation group was by external application of Wei Ling Xian (Radix Clematidis) extract at topical area in addition to the treatment given to the EA group. The intervention lasted 14 d in both groups. X-ray examination of knee joint was ordered before and after treatment, as well as the detection of positive expression of matrix metalloproteinase-1 (MMP-1) in cartilage of knee joint, hyaluronic acid (HA) and interleukin-1β (IL-1β) in the inflammatory effusion; the Western Ontario and McMaster Universities osteoarthritis index (WOMAC) and visual analogue scale (VAS) were adopted to evaluate the clinical efficacy.

Results

In the observation group, the X-ray examination result of knee joint was significantly improved, the positive expressions of MMP-1 and IL-1β content were significantly decreased, the level of HA was increased, WOMAC and VAS scores dropped, and the total effective rate was 91.5%, which were significantly different from those in the EA group (P<0.05).

Conclusion

EA plus external application of Wei Ling Xian (Radix Clematidis) extract can produce a more significant efficacy in treating KOA compared to ordinary EA treatment.

摘要

目的

探讨电针联合外敷自制威灵仙浸膏治疗膝骨性关节炎(knee osteoarthritis, KOA)的作用机制并观察 疗效, 为KOA 的治疗提供理论基础及新方案。

方法

将284 例KOA 住院患者采用随机数字表分为电针组和观察 组, 每组142 例。电针组采用电针、超短波理疗及口服盐酸氨基葡萄糖胶囊治疗, 观察组在电针组治疗基础上加 用局部外敷自制威灵仙浸膏。两组均治疗14 d。治疗前后采用X 线影像检查膝关节, 病理检查膝关节软骨基质金 属蛋白酶-1 (matrix metalloproteinase-1, MMP-1)细胞阳性表达率, 测定患者关节炎积液中透明质酸(hyaluronic acid, HA)、白细胞介素-1β (interleukin-1β, IL-1β), 采用西安大略与麦克马斯特大学骨关节炎指数(Western Ontario and McMaster Universities osteoarthritis index, WOMAC)及视觉模拟量表(visual analogue scale, VAS)评分评价临床疗效。

结果

治疗后, 观察组患者膝关节X 线影像学检查结果明显好转, MMP-1 阳性表达率及IL-1β含量明显降低, HA 明显升高, WOMAC、VAS 评分降低, 总有效率为97.2%, 与电针组比较, 差异均有统计学意义(P<0.05)。

结论

电针联合自制威灵仙浸膏外敷治疗KOA 疗效优于常规电针治疗。

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yang JG, Zhu QH. Sixty-one knee osteoarthritis treated with triple needling. TCM Res, 2013, 26(8): 58–60.

    Google Scholar 

  2. Amin AR1, Dave M, Attur M, Abramson SB. COX-2, NO, and cartilage damage and repair. Curr Rheumatol Rep, 2000, 2(6): 447–453.

    Article  CAS  PubMed  Google Scholar 

  3. Qu HY, Wang RH, Liu J. Clinical observation on warm needling in canicular days for knee osteoarthritis. J Acupunct Tuina Sci, 2015, 13(1): 63–65.

    Article  Google Scholar 

  4. Liu XX, Lin YP. Integrated Medicine for Knee Osteoarthritis. Beijing: People’s Medical Publishing House, 2009: 100–101.

    Google Scholar 

  5. Shi GY, Li ZG. Diagnosis and Treatment for Arthritis. Beijing: People’s Medical Publishing House, 2009: 189.

    Google Scholar 

  6. Jiang XY, Wang DW. Criteria of Clinical Efficacy for Orthopedics. Beijing: People’s Medical Publishing House, 2005: 203–204.

    Google Scholar 

  7. Xie JH, Liu MZ, Cui LQ. Effect of Qing Bi decoction on VAS and WOMAC osteoarthritis index in knee osteoarthritis. Hebei Zhongyiyao Xuebao, 2011, 26(1): 16–19.

    Google Scholar 

  8. Yang RC, Yang JH. Therapeutic observation of acupuncture-moxibustion plus Chinese medicinal fumigation for knee effusion. Shanghai Zhenjiu Zazhi, 2014, 33(5): 459–460.

    Google Scholar 

  9. Zhou YL, Li J, Hou WG, Bao CL, Zhang Q, Wang SS, Wu HG. Clinical observation of moxibustion in treatment of knee osteoarthritis. Shanghai Zhenjiu Zazhi, 2014, 33(12): 1086–1088.

    Google Scholar 

  10. Li ZH. Research analysis of Wei Ling Xian (Radix Clematidis). Zhongyi Zhongyao, 2007, 45(20): 62–63.

    Google Scholar 

  11. Zhou XS, Zhou K, Tan AX, Li MJ, Yi DB. Effect of Wei Ling Xian (Radix Clematidis) on knee structure and function of rabbit models with knee osteoarthritis. Shizhen Guoyi Guoyao, 2011, 22(10): 2454–2457.

    Google Scholar 

  12. Tang T, Chen DS, Li L, Zhu KG. Clinical study on the treatment of osteoarthritis of the knee with Tongbi topical ointment combined with articular cavity effusion flushing. Guoji Zhongyi Zhongyao Zazhi, 2014, 36(3): 213–216.

    Google Scholar 

  13. Wang JQ, Xue AR. Fifty-six knee osteoarthritis treated with ultra-micro needle-knife plus tuina. TCM Res, 2012, 25(9): 54–57.

    Google Scholar 

  14. Zhou XS, Zhou K. Studied on analgesic and antiinflammatory effects of Clematis Chinensis Osbeck. Zhongguo Yiyao Daobao, 2009, 6(11): 39–40.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pain Department of Taihe Hospital, Shiyan, Hubei Province, Hubei, 442000, China

    Min Li  (李敏)

  2. Department of Acupuncture and Moxibustion, Taihe Hospital, Shiyan, Hubei Province, Hubei, 442000, China

    Wei Fang  (方伟), Jing-ping Mu  (穆敬平) & Li-hong Guo  (郭俐宏)

  3. Laboratory of Hubei University of Medicine, Hubei, 442000, China

    Li Li  (李莉)

Authors
  1. Min Li  (李敏)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wei Fang  (方伟)
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jing-ping Mu  (穆敬平)
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Li Li  (李莉)
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Li-hong Guo  (郭俐宏)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Li-hong Guo  (郭俐宏).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, M., Fang, W., Mu, Jp. et al. Electroacupuncture plus external application of Chinese medicine for knee osteoarthritis. J. Acupunct. Tuina. Sci. 14, 41–45 (2016). https://doi.org/10.1007/s11726-016-0892-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11726-016-0892-8

Keywords

关键词

中图分类号

文献标志码

Search

Navigation