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Present situation and prospects about application of microelectrode array in study on acupuncture efficacy

微电极阵列在针灸效应研究中的应用现状及前景

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Abstract

As a component of traditional Chinese medical therapies, the therapeutic effects of acupuncture for some nervous system diseases have been proven by a large number of clinical and experimental studies. But, the electrophysiological techniques of the commonly used EEG and evoked potentials are still not sufficient to reveal the functional mechanism of acupuncture therapy. The recording technique of microelectrode array (MEA), a kind of electrophysiological technique originated from the overseas biological electrical signal monitoring technique, can be used to record multiple electrical signals of the nervous cells in vivo or in vitro, and maintain the accuracy and stability of the recorded information at the same time, which greatly enriches the means of electrophysiological study. This technique has been already applied in the basic study and clinical treatment abroad, but it is very seldom used in the study of acupuncture field. In order to guide the application of MEA in the research field of acupuncture science, a general survey about the application of MEA technique in vivo was done, and the present situation and prospects of the application of the technique in acupuncture science was briefly analyzed.

摘要

针灸疗法作为中医传统疗法的一部分, 其对部分神经系统疾病的疗效已被大量的临床与实验研究所证实, 然而现有常用的脑电图、 诱发电位等电生理技术对于揭示针灸的作用机理尚有诸多不足之处。 微电极阵列记录技术是起源于国外的生物电信号监测技术, 属于电生理技术的一种, 可在体或离体同时记录多个神经细胞的电信号, 同时又保持记录信息的准确性、 稳定性, 较大程度丰富了电生理学研究的手段。 该技术虽然在国外已经应用于基础研究和临床治疗, 但是将该技术应用于针灸学领域的研究并不多见。 对微电极阵列技术的在体应用情况进行综述, 简要分析该技术应用于针灸学研究的现状及前景, 以指导微电极阵列技术在针灸学研究领域的应用。

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Authors and Affiliations

  1. Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China

    Qing Han  (韩清) & Jia Xu  (徐佳)

  2. Shanghai Research Institute of Acupuncture and Meridian, Shanghai, 200030, China

    Ming-shu Xu  (徐鸣曙) & Ming-zhe Li  (李明哲)

  3. Shanghai Qigong Research Institute, Shanghai, 200030, China

    Lin-bao Ge  (葛林宝)

  4. Shanghai Research Center for Acupuncture & Meridian, Shanghai, 201203, China

    Lin-bao Ge  (葛林宝)

  5. Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China

    Ying-jie Zhang  (张英杰)

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  1. Qing Han  (韩清)
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Correspondence to Ming-shu Xu  (徐鸣曙).

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Han, Q., Xu, Ms., Xu, J. et al. Present situation and prospects about application of microelectrode array in study on acupuncture efficacy. J. Acupunct. Tuina. Sci. 13, 134–140 (2015). https://doi.org/10.1007/s11726-015-0837-7

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  • DOI: https://doi.org/10.1007/s11726-015-0837-7

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