Review of acupuncture treatment for perimenopausal syndrome




To summarize the mechanism of acupuncture in treating perimenopausal syndrome (PMS) from the aspects of reproductive endocrinology, immune system, neuroendocrine, the metabolism of free radicals and bone, and the effect of lipid.


The databases including MEDLINE, EMBASE, CNKI, Wanfang, and CQVIP were searched from the launch of each database to June 2014 for relevant papers involving clinical and laboratory researches about PMS treated with acupuncture.


Acupuncture is a safe, effective, and scientific method in treating PMS, and the efficacy is significant.


Considering the limits of previous studies, future research should use high technologies such as molecular biology and genetic testing, and adopt multicenter randomized controlled study method to evaluate the efficacy of acupuncture in treating female PMS, and to further explore the mechanism of acupuncture in treating PMS.



从生殖内分泌、 免疫系统、 神经内分泌、 自由基和骨的新陈代谢、 血脂改变的角度, 总结针刺治疗围绝经期综合征的机制。


检索了截止到2014年6月发表的临床和实验的针刺治疗围绝经期的研究, 检索数据库包括MEDLINE, EMBASE, CNKI, 万方和重庆维普。


针刺治疗围绝经期综合征是安全的、 有效的、 科学的, 疗效是显著的。


以前的研究存在一定的局限性, 以后再开展研究时, 应采用诸如分子生物学、 基因检测等高科技, 也应开展更多的随机对照临床试验来评估针刺治疗围绝经期综合征的疗效, 进一步探讨针刺治疗围绝经期综合征的机制。

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  1. [1]

    Ng EH, So WS, Gao J, Wong YY, Ho PC. The role of acupuncture in the management of subfertility. Fertile Steil, 2008, 90(1): 1–13.

    Article  Google Scholar 

  2. [2]

    Chou W, Bringhurst JC. Neuroendocrine mechanisms of acupuncture in the treatment of hypertension. Evid Based Complement Alternat Med, 2012: ID878673.

    Google Scholar 

  3. [3]

    Zhang XZ, Peng YM, Yu JC, Liu CZ, Han JX. Effects of acupuncture on expression of OPG and BMP-2 in SAMP6 mouse with osteoporosis. Zhonghua Zhongyiyao Zazhi, 2008, 23(8): 672–675.

    CAS  Google Scholar 

  4. [4]

    Xie JP, Nong Y, Jia JJ, Li W, Zhang LF, Chen X, Li XH, Gao Y. Efficacy comparison of needling Fenglong (ST 40) and coordinated acupoints for regulating blood lipid level in rats with hyperlipemia. Beijing Zhongyiyao Daxue Xuebao, 2008, 31(2): 141–144.

    CAS  Google Scholar 

  5. [5]

    Yu JS, Zeng BY, Hsieh CL. Acupuncture stimulation and neuroendocrine regulation. Int Rev Neurobiol, 2013, 111: 125–140.

    Article  PubMed  Google Scholar 

  6. [6]

    Eshkevari L, Permaul E, Mulroney SE. Acupuncture blocks cold stress induced increases in the hypothalamus-pituitary-adrenal axis in the rat. J Endocrinol, 2013, 217(1): 95–104.

    Article  CAS  PubMed  Google Scholar 

  7. [7]

    Cooper GS, Baird DD, Darden FR. Measures of menopausal status in relation to demographic, reproductive, and behavioral characteristics in a population-based study of women aged 35–49 years. Am J Epidemiol, 2001, 153: 1159–1165.

    Article  CAS  PubMed  Google Scholar 

  8. [8]

    Xu L. Scientific analysis of the merits and demerits of HRT. Zhonghua Fuchanke Zazhi, 2002, 37(10): 577–579.

    Google Scholar 

  9. [9]

    Gompel A. Micronized progesterone and its impact on the endometrium and breast versus progestogens. Climacteric, 2012, 15(1): 18–25.

    Article  CAS  PubMed  Google Scholar 

  10. [10]

    Mueck AO. Postmenopausal hormone replacement therapy and cardiovascular disease: the value of transdermal estradiol and micronized progesterone. Climacteric, 2012, 5(1): 11–17.

    Article  Google Scholar 

  11. [11]

    Lu HB, Yang XZ. The status of epidemiological studies on perimenopausal syndrome. Guangxi Yixue, 2001, 23(5): 1131–1134.

    Google Scholar 

  12. [12]

    Kakkar V, Kaur D, Chopra K, Kaur A, Kaur IP. Assessment of the variation in menopausal symptoms with age, education and working/non-working status in north-Indian sub population using menopause rating scale (MRS). Maturitas, 2007, 57(3): 306–314.

    Article  CAS  PubMed  Google Scholar 

  13. [13]

    Chen BY. Acupuncture normalizes dysfunction of hypothalamic-pituitary-ovarian axis. Acupunct Electrother Res, 1997, 22(2): 97–108.

    CAS  PubMed  Google Scholar 

  14. [14]

    Zhao H, Tian ZZ, Chen BY. Electroacupuncture stimulates hypothalamic aromatization. Brain Res, 2005, 1037(1–2): 164–170.

    Article  CAS  PubMed  Google Scholar 

  15. [15]

    Cheng K, Tian SL. Effects of preventive-electroacupuncture of “Guanyuan” (CV 4) and “Sanyinjiao” (SP 6) on hypothalamus-pituitary-ovary axis in ovariectomized rats. Zhen Ci Yan Jiu, 2012, 37(1): 15–19.

    CAS  PubMed  Google Scholar 

  16. [16]

    Hu L, Wang HL, Gao XZ, Shen XM, Jin R, Zhu QC, He ZB. Comparison of regulative effects of electro-acupuncture at “Guanyuan” (CV 4) and “Sanyinjiao” (SP 6) on sex hormones and hypothalamic β-endorphin in perimenopausal model rats. Zhongguo Zhen Jiu, 2004, 24(9): 649–651.

    CAS  Google Scholar 

  17. [17]

    Tian HZ, Zhang CY, Duan SM. The combined use of acupuncture and Chinese medicines for treatment of menopausal syndrome: a clinical report of 63 cases. Zhongyi Zazhi, 2008, 28(1): 3–4.

    Google Scholar 

  18. [18]

    Zhou J, Qin ZY, Li WL, Zhang CP, Tian LY, Zhang YJ, Hu L. Clinical observation on therapeutic effect of electro-acupuncture at Sanyinjiao (SP 6) on peri-menopausal syndrome. Zhongguo Zhen Jiu, 2006, 26(9): 617–620.

    PubMed  Google Scholar 

  19. [19]

    Zhou K, Jiang J, Wu J, Liu Z. Electroacupuncture modulates reproductive hormone levels in patients with primary ovarian insufficiency: results from a prospective observational study. Evid Based Complement Alternat Med, 2013: ID657234.

    Google Scholar 

  20. [20]

    Shang YJ, Bhang Y, Kong LL, Wang YY, Wang DS, Li J. Clinical observation on combination of source point and Back-Shu point for treatment of perimenopausal syndrome. Zhongguo Zhen Jiu, 2009, 29(6): 444–448.

    PubMed  Google Scholar 

  21. [21]

    Jin H, Liu TT, Wang R. Clinical observation on acupuncture at the five-zangshu for treatment of perimenopausal syndrome. Zhongguo Zhen Jiu, 2007, 27(8): 572–574.

    PubMed  Google Scholar 

  22. [22]

    Qin ZY, Ling H, Xia XH, Meng L, Wu ZJ. Effects of electroacupuncture of Sanyinjiao (SP 6) on genito-endocrine in patients with perimenopausal syndrome. Zhen Ci Yan Jiu, 2007, 32(4): 255–259.

    PubMed  Google Scholar 

  23. [23]

    Li Y, Xia Y, Liu SM, Ju ZY, Shi XL, Chen MG, Cheng L, He JS. Effect of electroacupuncture on serum sex hormones in patients with perimenopausal syndrome. Shanghai Zhenjiu Zazhi, 2010, 29(4): 199–201.

    CAS  Google Scholar 

  24. [24]

    Liu DH. Observations on the efficacy of acupuncture and moxibustion plus psychotherapy in treating female climacteric syndrome. Shanghai Zhenjiu Zazhi, 2009, 28(7): 373–374.

    Google Scholar 

  25. [25]

    Wei XC, Zhang XX, Chen DY, Xie XL. Observation and nursing of 60 cases of perimenopausal syndrome treated with abdominal acupuncture. Dangdai Huli, 2012, 4(4): 105–107.

    Google Scholar 

  26. [26]

    Chen XL, Luo RH. Clinical observation of electro-acupuncture treatment for menopausal syndrome. Zhenjiu Linchuang Zazhi, 2013, 29(8): 35–37.

    CAS  Google Scholar 

  27. [27]

    Xia XH, Hu L, Qin ZY, Zhou J, Li M, Li WL, Tian LY, Zhang YJ. Multicentral randomized controlled clinical trials about treatment of perimenopausal syndrome with electroacupuncture of Sanyinjiao (SP 6). Zhen Ci Yan Jiu, 2008, 33(4): 262–266.

    PubMed  Google Scholar 

  28. [28]

    Sunay D, Ozdiken M, Arslan H, Seven A, Aral Y. The effect of acupuncture on postmenopausal symptoms and reproductive hormones: a sham controlled clinical trial. Acupunct Med, 2011, 29(1): 27–31.

    Article  PubMed  Google Scholar 

  29. [29]

    Su CM, Jiang LJ, Yu LJ. Clinical observation on perimenopausal syndrome treated by acupuncture. Dalian Yike Daxue Xuebao, 2007, 29(4): 380–381.

    Google Scholar 

  30. [30]

    He JS, Liao JQ, An XY, Xu JM, Wang J. Analysis of the clinical effect of electroacupuncture on peri-climacteric syndrome. Shanghai Zhenjiu Zazhi, 2005, 24(12): 3–5.

    Google Scholar 

  31. [31]

    Chen BY, Cheng LH, Gao H, Ji SZ. Effects of electroacupuncture on the expression of estrogen receptor protein and mRNA in rat brain. Shengli Xuebao, 1998, 50(5): 495–500.

    CAS  Google Scholar 

  32. [32]

    Ma S, Wu J, Feng Y, Chen B. Elevated estrogen receptor expression in hypothalamic preoptic area decreased by electroacupuncture in ovariectomized rats. Neurosci Lett, 2011, 492(2): 109–113.

    Article  Google Scholar 

  33. [33]

    Li XH, Zheng L, Xie JP, Zhang LF, Zhai JH, Zhou J, Tian YC, Zhou DF, He YW, Qu LM. Experimental study on changes of expressions of ER-alpha and ER-alpha mRNA in different hypothalamic nuclei and the affect of “preventive acupuncture and moxibustion” in ovariectomy rats. Zhongguo Zhen Jiu, 2008, 28(12): 918–922.

    CAS  PubMed  Google Scholar 

  34. [34]

    Yao X, Wang XQ, Ma SL, Chen BY. Electroacupuncture stimulates the expression of prolactin-releasing peptide (PrRP) in the medulla oblongata of ovariectomized rats. Neurosci Lett, 2006, 411(3): 243–248.

    Article  PubMed  Google Scholar 

  35. [35]

    Cheng LN, Du GZ, Chen BY. The biochemical mechanism of electroacupunctrue regulation of dysfunctional hypothalamic-pituitary-ovarian axis in ovariectomized rats. Shanghai Zhenjiu Zazhi, 2001, 20(6): 32–34.

    CAS  Google Scholar 

  36. [36]

    Horvath TL, Roa-Pena L, Jakab RL, Simpson ER, Naftolin F. Aromatase in axonal processes of early postnatal hypothalamic and limbic areas including the cingulate cortex. J Steroid Biochem Mol Biol, 1997, 61(3-6): 349–357.

    Article  CAS  PubMed  Google Scholar 

  37. [37]

    Wang WJ, Yu J, Li DJ, Bu SZ. Observation on the changes of splenic ER, IL-2and TNF levels in aging female rats. Zhonghua Neifenmi Daixie Zazhi, 1999, 15(4): 225–228.

    Google Scholar 

  38. [38]

    Li J, Cui JM, Bao JT, Jia YS, Yao RM. Explore the relationship between acupuncture effect and modern immune. Shizhen Guoyi Guoyao, 2010, 21(8): 2058–2060.

    Google Scholar 

  39. [39]

    Chen JX, Liu YY, Guo Y, Chen SB, Guo YM. Experimental study of acupuncture Zusanli (ST 36) on the effect of the concentration of partial immune substances in healthy rats. The 2nd Conference on Pricking Cupping of China Association of Acupuncture-moxibustion, 2012: 78.

    Google Scholar 

  40. [40]

    Liu HY, Wang B. Effect of electrical acupuncture on neuroendocrine of rats during climacteric period. Jiangsu Zhongyiyao, 2003, 24(1): 49–51.

    CAS  Google Scholar 

  41. [41]

    Brown ER, Harlan RE, Krause LE. Gonadal steroid regulation of substance P (SP) and SP-encoding messenger ribonucleic acids in the rat anterior pituitary and hypothalamus. Endocrinology, 1990, 126(1): 330–334.

    Article  CAS  PubMed  Google Scholar 

  42. [42]

    Yan LJ, Wang XQ, Guo SZ. Opioid peptide with its receptor and female reproductive endocrinology. Shanxi Yike Daxue Xuebao, 2003, 34(4): 374–376.

    CAS  Google Scholar 

  43. [43]

    Yu JS, Zeng BY, Hsieh CL. Acupuncture stimulation and neuroendocrine regulation. Int Rev Neurobiol, 2013, 111: 125–140.

    Article  PubMed  Google Scholar 

  44. [44]

    Guan F, Ma SL, Chen BY. Effects of electro-acupuncture on signal transduction pathway of hypothalamic neuroendocrine system in ovariectomized rats. Zhongxiyi Jiehe Xuebao, 2009, 7(6): 563–568.

    CAS  PubMed  Google Scholar 

  45. [45]

    Hao JW, Ma SL, Jiang JW, Chen BY. A study of in vitro effects by nucleus microinjection of acupuncture push-pull perfusion fluid from preoptic area of ovariectomized rats. Shanghai Zhenjiu Zazhi, 2006, 25(9): 46–50.

    Google Scholar 

  46. [46]

    Bao YX, Lü GH. Effect of acupuncture on dysmnesia and monoamine neurotransmitter of dementia mice. Shanghai Zhenjiu Zazhi, 2003, 22(7): 23–25.

    Google Scholar 

  47. [47]

    Fang YR, Wang LJ, Zhou X. The changes of serum sex hormone levels, free radicals, and lipid content in perimenopausal women. Shiyong Fuchanke Zazhi, 2004, 20(3): 151–152.

    Google Scholar 

  48. [48]

    Lin SR. Effect of acupuncture “Shenshu” (BL 23) and “Guanyuan” (CV 4) on the activity of renal tissue antioxidant enzyme in aging rats. Zhongyiyao Xuekan, 2005, 23(3): 538.

    Google Scholar 

  49. [49]

    Li M, Wang G, Zhang W, Wang MQ, Zhang YZ. Effects of electroacupuncture of yongquan acupoint on the expression of p53 and bcl-2 in aging model rats. Zhongguo Linchuang Kangfu, 2004, 8(9): 1788–1790.

    CAS  Google Scholar 

  50. [50]

    Cong SY, Li YD, Li JN, Wu HC. The experimental research on influence of the content of the NO, SOD and MDA by needling “Zusanli” and “Guanyuan” point of brain tissues of the old pantheress big rats. Zhenjiu Linchuang Zazhi, 2006, 22(9): 47–48.

    Google Scholar 

  51. [51]

    Bai W, Jiang GH, Xu Q, Zhang FL. Effect of acupuncture “Zusanli” (ST 36) and “Guanyuan” (CV 4) on the content of NO, SOD and MDA in menopausal female rats. Zhongyiyao Xuebao, 2009, 37(6): 90–91.

    Google Scholar 

  52. [52]

    Korljan B, Bagatin J, Kokic S, Berovic Matulic N, Barsic Ostojic S, Dekovic A. The impact of hormone replacement therapy on metabolic syndrome components in perimenopausal women. Med Hypotheses, 2010, 74(1): 162–163.

    Article  CAS  PubMed  Google Scholar 

  53. [53]

    Eshtiaghi R, Esteghamati A, Nakhjavani M. Menopause is an independent predictor of metabolic syndrome in Iranian women. Maturitas, 2010, 65(3): 262–266.

    Article  PubMed  Google Scholar 

  54. [54]

    Cai H, Yuan AH. Effect of acupuncture on NO contents of serum and activity of myeloperoxidase in rat with hyperlipoidemia. Hebei Zhongyi, 2010, 32(9): 1404–1406.

    Google Scholar 

  55. [55]

    Li CJ, Cheng XS, Li CY, Cui MZ, Sun ZR. Regulative effects of acupuncture at Fenglong (ST 40) acupoints on the blood lipids of normal rats and those with hyperlipemia. Zhongguo Linchuang Kangfu, 2005, 9(27): 86–87.

    Google Scholar 

  56. [56]

    Rerksuppaphol L, Rerksuppaphol S. A randomized controlled trial of electroacupuncture at body acupoints and Fenglong for regulating serum lipids in dyslipidemic patients in Thailand. Complement Ther Clin Pract, 2014, 20(1): 26–31.

    Article  PubMed  Google Scholar 

  57. [57]

    Xie JP, Li XH, Zhang LF, Chen K. Experimental study on the effects of puncturing different points on blood lipid in rats with hyperlipemia. Beijing Zhongyiyao Daxue Xuebao, 2003, 26(5): 80–83.

    CAS  Google Scholar 

  58. [58]

    Xu TS. Research on auricular acupuncture combined with body acupuncture for menopausal syndrome. Xiandai Zhongxiyi Jiehe Zazhi, 2004, 13(17): 2269–2270.

    Google Scholar 

  59. [59]

    DeSlem CJ, Takahata Y, Warren J, Chappel JC, Khan T, Li X, Liu C, Choi Y, Kim YF, Zou W, Teitelbaum SL. IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner. J Cell Biochem, 2012, 113(9): 2895–2902.

    Article  Google Scholar 

  60. [60]

    Lukefahr AL, Frye JB, Wright LE, Marion SL, Hoyer PB, Funk JL. Decreased bone mineral density in rats rendered follicle-deplete by an ovotoxic chemical correlates with changes in follicle-stimulating hormone and inhibin A. Calcif Tissue Int, 2012, 90(3): 239–249.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. [61]

    Li J, Wang Y, Li P. Biochemical research on effect of acupuncture and moxibustion on bone metabolism in castrated rats. Tianjin Zhongyiyao, 2008, 25(1): 26–28.

    Google Scholar 

  62. [62]

    Ma J, Hu YG, Zhang DH. Effects of acupuncture on bone metabolism and serum estradiol level in ovariectomy-induced osteoporosis rats. Zhen Ci Yan Jiu, 2008, 33(4): 235–239.

    PubMed  Google Scholar 

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Correspondence to Xiao-ke Wu 吴效科.

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Li, Rl., Fu, Jy., Deng, Yy. et al. Review of acupuncture treatment for perimenopausal syndrome. J. Acupunct. Tuina. Sci. 13, 129–133 (2015).

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  • Acupuncture Therapy
  • Perimenopause
  • Climacteric
  • Women
  • Review


  • 针刺疗法
  • 围绝经期
  • 更年期
  • 妇女
  • 综述


  • R246.3